Endocrine Abstracts

Objective: The aim of this exploratory study was to assess the effect of growth hormone on semen parameters in men with primary infertility and normogonadotropic idiopathic oligoasthenospermia.Method: This study was performed as a prospective, open- label, non-randomized observational study in a private practice in fourteen men, aged 26 to 35, with normogonadotropic idiopathic oligoasthenospermia. Growth hormone 1.5 IU/day was administered for 6 months a...

Background: Post-operative hypocalcaemia affects up to 30% of patients. It may be delayed to the second or third post-operative day and is therefore the key determinant of post-operative stay. Various strategies have been used to overcome this problem including the blanket administration of calcium and discharge followed by daily blood tests.Objectives: To evaluate the use of using a parathyroid hormone (PTH) assay 4 h following surgery as a predictor of...

BackgroundIndividuals who do day/night shifts or who are exposed to 24 hours of daylight have a greater CVS risk. This may relate to effects on the diurnal rhythm of sleep, appetite or cortisol.AimsTo investigate the variations in the diurnal cortisol secretion, appetite and sleep in young healthy civilians from the UK during a five week expedition to Svalbard in the Arctic with 24 hours of daylight.<p cl...

BackgroundThyrotropin Stimulating Hormone Suppression Therapy (TSHST) in Differentiated Thyroid cancer (DTC) patients can result in reduced bone mineral density (BMD) which is a potential serious problem [1]. Studies on the effects of TSHST on BMD have demonstrated conflicting results [2–5]. There is insufficient guidance regarding the degree and duration of TSHST in the context of skeletal effects despite multiple existing guidelines.<p class="...

IntroductionStress and anxiety have become major killers in our developed and devloping countries both. Literature has shown reluction in stress results in better owerall well being. lack of sleep is also a contibutor to stress.In T2DM patients this becomes even more important as the have higher oxidative stress, Yoga Nidra is already prescribed by scholars in several countries because of its potential to activate the parasympathetic nervous system and p...

Adrenal vein sampling (AVS) is used to differentiate between unilateral and bilateral subtypes of primary aldosteronism (PA). However, AVS results may be misinterpreted due to a procedural artefact resulting in low aldosterone levels at the inferior vena cava (IVC), thus making an interpretation of aldosterone to renin ratios difficult. We investigated whether this artefact was due to patients’ being supine before and during AVS, given aldosterone varies with posture, and...

A 68-year-old gentleman presented with proximal myopathy in association with severe hypokalaemia (K+ 2.3mmol/l) and metabolic alkalosis. He had recently been diagnosed with type 2 diabetes. His random cortisol was 1045nmol/l. His 24-h urinary free cortisol was 3536nmol/24 h, and midnight cortisol was 85nmol/l. On a low dose dexamethasone suppression test, his cortisol failed to suppress (cortisol 1195–983nmol/l, ACTH 275ng/l), consistent with ACTH-dependent Cushing’s...

Phaeochromocytomas are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. We report a 68-year-old female who was found to have a locally arising colonic adenocarcinoma on biopsies. Staging also identified a 10.7 cm right adrenal lesion and work-up revealed markedly raised urinary metanephrines and positive MIBG imaging. The MDT decision was to first remove the colonic cancer with appropriate alpha blockade. It was felt that a comb...

Despite conventional treatment with oral calcium and active vitamin D, patients with chronic hypoparathyroidism (cHypoPT) can remain not adequately controlled (NAC) and have abnormal biochemistry, disease complications, or symptoms impacting quality of life. A systematic literature review (SLR) was conducted to evaluate the clinical burden for patients with cHypoPT, with an emphasis on patients with NAC disease. This abstract focuses on data related to renal and cardiovascular...

Glycogen Hepatopathy (GH) was initially described in 1930 by Pierre Mauriac. 90 years later, GH remains underrecognized in adults. The clinical or radiological characterization of GH is difficult, further compounded by lack of widespread literature. We present two cases of GH characterized by recurrent lactatemia and transient liver function and radiological abnormalities.• 19 years old male with Type 1 diabetes admitted with nausea and vomiting. pH...