Endocrine Abstracts

This multicentric, observational, non interventional study of patients with type 1 diabetes observed their knowledge, attitudes and practices regarding complementary and alternative medicine (CAM), including nutraceuticals. One hundred and thirty-five subjects with type 1 diabetes, aged <20 years, and their parents were surveyed using a structured pre-tested questionnaire.The cohort included 65.92% boys, 37.04% rural dwellers and 31.85% patients with...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is regarded as a precursor to the development of carcinoid tumorlets. It is confined to the neuroendocrine cell of the airway mucosa without penetration through the basement membrane and appears in a diffuse pattern, typically in association with obliterative bronchiolar fibrosis. DIPNECH belongs to the preinvasive lesions defined by the 1999 World Health Organization classification, along with atypical ade...

Background: Musculoskeletal symptoms are common but unrecognized symptoms of thyroid dysfunction. We present a case report of an elderly man presenting with acute paraparesis as the first manifestation of thyrotoxicosis.Case report: A 73-year man presented with 1-week history of weakness in both legs and inability to mobilize or stand. Neurological examination revealed severe proximal muscle weakness (grade 0/5 power) of both lower limbs with reduced ten...

Background: NF1 and MEN2 are rare conditions known to associate with bilateral phaeochromochtomas. We describe, with relevant associated radiology, a NF1 patient developing a series of neuroendocrine tumours including bilateral phaeochromocytomas.Clinical case: A 39-year-old lady presented with long standing episodic abdominal pain, diarrhoea, palpitation and sweating. Past history includes first arch syndrome and NF1 at teens and total thyroidectomy for...

TSH secreting tumours (TSH-omas) are uncommon, accounting for less than 2% of pituitary tumours. Typically, patients with such tumours demonstrate hyperthyroidism with detectable or elevated TSH levels, and show little response to TRH stimulation. Treatment is controversial: typically surgery, radiotherapy or somatostatin analogues.We present a 22 year-old man who was found to be tachycardic on joining a gym in 2003. There were no other symptoms or signs...

We report a new diagnosis of a pituitary TSH-oma together with a metastaticneuroendocrine tumour. A 61 year old man presented with a 3-year history of diarrhoea. His past medical history includes paroxysmal atrial fibrillation, for which he has had an ablation in the past. He takes no regular medications. Initial investigations were suggestive of hyperthyroidism in the context of unusual thyroid function test results (elevated freeT4 and freeT3 with elevated TSH). A pituitary ...

Background: It is well established that during pregnancy, normal physiological changes occur concomitant with an enhanced metabolic demand for thyroxine/iodine. If dietary iodine intake is sufficient, normal equilibrium is achieved. With deficient iodine intake, the demand not being met, it is believed that pathological alterations occur leading to maternal thyroxineaemia and impaired growth and neurodevelopmental disorders in the offspring. However, there are very few studies...

Background: Peptide-receptor-radionuclide-therapy (PRRT) improves progression free survival in metastatic neuroendocrine neoplasia (NEN). To be suitable for PRRT, somatostatin receptor-2 (SSTR2) must be present on tumour site as determined by positive uptake on [68Ga]Ga-DOTA-peptide-PET/CT. LANTana is an ongoing study evaluating whether treatment with the demethylating agent, ASTX727, results in re-expression of SSTR2, as determined by [68Ga]Ga-DOTA-peptide-PE...

The role of magnesium in electrolyte homeostasis is well established. ATP/ADP structure, refractory hypokalemia and calcium homeostasis are some of the established roles in literature, well known to Endocrine. However, currently no NICE guidelines exist for low magnesium. Our first audit in 2018 focused on patient admissions during January 2018. We found 49 patients with Mg < 0.5. Majority were care of the Geriatrics, 8 under Gastroenterology, 4 under Endocrinology. 31 pat...

Background: Pituitary apoplexy is a relatively rare but important clinical syndrome which may be associated with acute headache, visual compromise and hypopituitarism. It can be the initial presentation of a previously unsuspected pituitary macroadenoma. Recognised risk factors include hypertension and the use of antiplatelet agents and/or anticoagulant therapy. It may be life-threatening, requiring emergency endocrine (e.g hydrocortisone) replacement therapy[1] and...