Endocrine Abstracts

A 33 year-old-lady presented to the emergency department with acute abdominal pain and per vaginal bleeding. Her last menstrual period was six weeks prior to admission. She had a positive urine pregnancy test and a trans-vaginal ultrasound confirming an ectopic tubal pregnancy. She underwent an emergency laparoscopic right salpingectomy under general anaesthesia with blood loss intra-operatively of 300 ml. One day post-op, her haemoglobin dropped from 129 g/l to 86 g/l. She re...

Introduction: Localising the aetiology of Cushing’s syndrome can be challenging, especially when investigations utilised are limited in their sensitivities and specificities. We present a case whereby the reliabilities of laboratory and radiological investigations are tested to their limits.Case Presentation: A 70 year old female presented with a one year history of fatigue, weight gain and headaches. She had proximal myopathy, cheek telangiectasia ...

Objectives: The number of people with diabetes is increasing globally; hence necessitate identifying diabetes earlier and more efficiently. Recently, American Diabetes Association (ADA) recommended the use of glycated haemoglobin (HbA1c) as an alternative to glucose based criteria for diagnosing type 2 diabetes and pre-diabetes. Hence, we aimed to evaluate the discrepancies between HbA1c- and glucose-based criteria for diagnosis of diabetes and pre-diabetes in Nepalese populat...

Background: Hypogonadism in males is associated with a reduction in bone mineral density (BMD). It is known that the reversal of this is achievable through adequate hormone replacement; however, the degree to which this is dependent on the proportion of time patients spend within the recommended therapeutic range (>15 nmol/l) in real-ife has not yet been established.Aim: To evaluate the degree to which the proportion of time that a hypogonadal p...

Background: Thyroid cancer is the most common malignant disease of the endocrine system. Thyroid cancer represents above 1% of all malignancies. There is a paucity of data on thyroid cancer in Nepalese patients.Aim: The aim of this study is to explore clinical profile of thyroid cancer patients diagnosed and managed in our center.Methods: A total of 70 patients with thyroid cancer were included in the sample from March 2013 to Dece...

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of Bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

We present this case of a 7-year-old female who had been well, without fever, polyuria or polydipsia, nor temperature intolerance. There was no known family history of auto-immune disorders. Physical exam was unremarkable but further labs revealed hyperglycemia (329 mg/dl), venous pH 7.37, glycosuria (no ketonuria). Her hyperglycemia resolved with intravenous and then subcutaneous insulin. Further labs revealed glutamic acid decarboxylase antibodies to be high (>30.0), and...

Introduction: There is scarcity of information regarding the profile of patients with Pheochromocytoma and paraganglioma from India.Aim: To study clinical profile of patients with Pheochromocytoma (PHEO)/Paraganglioma (PGL) attending the AIIMS hospital.Methodology:: Study protocol was approved by the AIIMS ethics committee. Written informed consent was taken from patients (parents in case of children). Patients of PHEO & PGL at...

Introduction: Chronic longstanding hypothyroidism is a known cause of pericardial effusion. However, cardiac tamponade as the primary presentation of Hashimoto’s hypothyroidism is relatively uncommon.Case description: A 34-year-old African American woman presented to the ER complaining of shortness of breath, fever, cough and precordial chest pain of 1 day duration. Examination revealed an obese female with patchy alopecia and dry skin in mild respi...

Factitious hypoglycaemia is characterised by high insulin levels but accompanied with low Proinsulin and C-peptide levels and a negative sulfonylurea screenWe present a 54-year-old woman who was initially diagnosed with type 2 diabetes in 2002 and by 2004, she was converted to insulin treatment due to poor tolerance to Metformin. She also had a previous history of Manic depressive psychosis and treated with lithium.In the months pr...