Endocrine Abstracts

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...

Ectopic ACTH secretion due to malignant tumours is a rare cause of hypercortisolism. Induced metabolic disturbances are often serious and the management of such patients may be difficult. We report the case of a 50-yr-old man who had a sporadic medullary thyroid carcinoma (MTC) removed 2 years ago (Dec/2003). Calcitonin and CEA levels remained high postoperatively and a CT scan revealed liver metastases. In August 2005 he was referred to Endocrinology with symptoms of muscular...

Background: In the general population, sleep disorders are associated with an increased risk of cognitive impairment; moreover, people with dementia often have sleep disturbances. The prevalence of sleep disorders, such as sleep apnea, in acromegalic patients is higher than in the general population, and they may have a higher risk of cognitive impairment due to acromegaly treatment (i.e. Radiotherapy) or cardiovascular comorbidities. In the literature, data about the relation...

Introduction: Bariatric surgery improves lipid profile. A still unanswered question is whether this improvement is merely weight dependent or also results from factors inherent to specificities of the bariatric procedure itself. We aimed to study lipid profile 1 year after bariatric surgery and compare its changes between the different procedures in patients matched for initial weight and for weight loss.Methods: We retrospectively analysed patients subm...

Introdution: Central diabetes insipidus(CDI) is a rare disease, with multiple aetiologies such as cranioencephalic traumatism and multiple sclerosis (ME). However, the association with ME is not commonly described. The clinical suspicion must be made in the presence of polyuria and polydipsia.Case report: Woman, 67 years-old, revealing history of ME relapsing-remitting subtype with 8 years of evolution, hypertension and dyslipidemia, medicated with inter...

Introduction: People with intracranial organic lesions, including pituitary tumours, may manifest initially as a psychiatric disorder, such as depression, emotional disturbance, anxiety, apathy, neurobehavioral disturbance, cognitive dysfunction and personality disturbance.Case Report: A male patient 45 years old was sent to the Department of Endocrinology of São João Hospital due to a pituitary macroadenoma. The patient referred asthenia, musc...

Introduction: Obesity is a heterogenous disorder. One of its subtypes that has been recently described is termed the metabolically healthy, but obese (MHO) individuals. Preliminary evidence suggests that this could be due to lower visceral fat levels and earlier onset of obesity.Objectives: To determine the prevalence of MHO in a sample of obese patients. To evaluate whether body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are...

Current evidence suggests that the adipocyte-derived hormone resistin (RSTN) regulates both feeding and peripheral metabolism through unclear hypothalamic-mediated mechanisms. Here, we demonstrate by the first time, that the anorectic effect of RSTN is associated to specific changes in the expression of neuropeptides in the arcuate nucleus of the hypothalamus (ARC), namely AgRP, NPY and CART. Very interestingly, RSTN also exerts a deep, nutritional-dependent inhibitory effect ...

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...

Background: Bariatric surgery has been associated with a decrease in multiple obesity-related comorbidities including obstructive sleep apnoea syndrome (OSA). This study aims to access the OSA evolution in obese patients who underwent bariatric surgery.Methods: Retrospective longitudinal study of a population of obese patients who underwent bariatric surgery between January/2010 and July/2014 in our centre. Only patients who have undergone polysomnograph...