Endocrine Abstracts

The characteristics of adrenal involvement in Multiple Endocrine Neoplasia type 1 (MEN1) have been defined from studies involving a limited number of patients. We have assessed retrospectively the prevalence, characteristics and evolution of adrenal involvement from the French group for the study of endocrine tumours (GTE) registry, involving 688 patients with MEN1. In our series, adrenal tumours identified at abdominal imaging occurred in 130 patients (18.9%). The mean age of...

Within the group of gonosomal aneuploidy, the 47,XXY Klinefelter syndrome is a well-known chromosomal anomaly with a clearly delineated phenotype. Since the 48,XXYY polysomy is rather rare and associated with hypogenitalism, it has often been considered as a variant of the Klinefelter syndrome. Nevertheless, several differences have been reported, in particular the greater severity and prevalence of mental retardation and psychiatric illness in patients with a 48,XXYY syndrome...

Introduction: Corticosteroids are amongst the most prescribed drugs and their use has been linked to cardiometabolic adverse events including weight gain and abdominal adiposity. We previously showed that users were also more likely to have the metabolic syndrome (MetS). Since an essential role in the pathway of glucocorticoid (GC) action is reserved for the glucocorticoid receptor (GR), it could be proposed that GC sensitivity altering polymorphisms could affect the vulnerabi...

Introduction: The prevalence of obesity is still increasing and is accompanied by significant health problems. High exposure to glucocorticoids, including the stress hormone cortisol, has been suggested to play a role in the development of obesity and associated cardiometabolic derangements. We previously showed that obese persons are exposed to high long-term cortisol levels as measured in scalp hair. It is not known whether these elevated cortisol levels decrease with weight...

Aim of the studyA relative can be an asset in dealing with chronic illnesses such as acromegaly where quality of life is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to explore the consequences of acromegaly in remission in the patient-relative dyad in a matter of quality of life and self-esteem.MethodsIn this French m...

Background: Growing evidence suggests that hypothalamic lipid sensing plays a key role in controlling food intake, fat deposition and energy balance and that its dysregulation could lead to obesity and type 2 diabetes (T2D). Recent investigations reported that sphingosine-1-phosphate (S1P) is involved in the hypothalamic control of energy homeostasis. Intra-cerebroventricular administration of S1P decreased food intake and increased energy expenditure in rodents.<p class="...

Endocrine Society guidelines recommend random growth hormone (RGH) <1 mcg/l as indicative of biochemical control of acromegaly. Growth hormone (GH) control may also be determined using the mean GH (MGH) of a growth hormone day curve (GHDC). We report a retrospective analysis of 461 consecutive GHDCs, from 121 patients with treated acromegaly, performed in a single centre between 2009 and 2019. Each GHDC contained 7–9 GH measurements (mean 8.9) taken at regular interva...

Background: Familial chylomicronaemia syndrome (FCS) is a rare, inherited disorder characterised by impaired clearance of triglyceride (TG)-rich lipoproteins from plasma, leading to severe hypertriglyceridaemia (HTG), which have major effects on both physical and mental health, and a markedly increased risk of acute pancreatitis. A large overlap in the phenotype between FCS and multifactorial chylomicronaemia syndrome (MCS) contributes to the inconsistency in how patients are ...

Background: Sex hormone-binding globulin (SHBG) is a dimeric glycoprotein synthesized in, and secreted from, hepatocytes. SHBG is also expressed in, but not secreted from, the prostate, where its role is unclear. The expression of SHBG is linked to lipid metabolism, and it also modulates transport and availability of androgen. Given its expression in the prostate and role in the androgen signalling axis, we postulated that expression of SHBG will increase in prostate cancer (P...

The use of gallium-68 (68Ga) is rapidly expanding with new applications arising almost every week. Therefore, the global availability of this nuclide is a critical issue. 68Ga is currently sourced from commercial 68Ge/68Ga generators but their production is limited by the availability of the parent nuclide 68Ge. Alternatively, the use of a 68Zn salt solution in a liquid target has been proposed [1] [2]. With thi...