Endocrine Abstracts

Introduction: Thyroid hormones and irisin increase energy expenditure and induce browning of adipose tissue. However, little is known about irisin physiology and regulation. Here we aim to elucidate whether thyroid hormones alter circulating irisin concentrations in humans.Design and subjects: One cross-sectional (case-control) evaluation and two interventions were performed independently from each other, including previously thyroidectomized patients. C...

Introduction: The aim of this study was to systematically review the literature for studies that have investigated possible differences in prevalence of subclinical Cushing’s syndrome (SCS) and related clinical implications between patients with unilateral (UAI) and bilateral adrenal incidentalomas (BAI) and to meta-analyze the best evidence available.Methods: Electronic databases PubMed, MEDLINE and EMBASE were systematically searched. Main study o...

Introduction: Inflammatory bowel disease (IBD) has been associated with various disorders of thyroid function. Many of these patients are now treated with biological agents targeting on TNF-a.Aim: To investigate thyroid function in patients with IBD and the potential effect of anti-TNF therapy.Patients and methods: We studied 41 patients with IBD (25M/16F, 36.4±11 years), without any known thyroid disorder. Eighteen patients (...

Introduction: Several studies have demonstrated associations of birth weight with metabolic and reproductive abnormalities in adults. The aim of this study was to investigate the birth weight in women with PCOS and its correlation with important clinical and biochemical parameters of the syndrome.Patients and methods: We studied 288 women with PCOS according to the NIH criteria (1990) and 166 women with normal cycles and without clinical or biochemical h...

Introduction: The clinical profile of patients with primary hyperparathyroidism has changed significantly in the last decades considering the fact that most cases are asymptomatic. This could be attributed to early diagnosis due to routinely serum calcium measurement. Only 5–27% of patients present with symptoms or signs related to osteoporosis, nephrolithiasis and hypercalcaemia. However, in patients with asymptomatic primary hyperparathyroidism (APHP) data concerning t...

Introduction: Denosumab is a new pharmacotherapy option for postmenopausal osteoporosis. It is a human monoclonal antibody against RANKL, acting as an osteoprotegerin (OPG) analog. Recently, osteoprotegerin levels were found to be elevated in type two diabetes while insulin resistance was shown to be positively associated with decreased serum OPG levels, in healthy obese subjects. However, no study has been conducted in order to clarify the effect of anti-RANKL factors adminis...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age and is characterized by chronic anovulation and clinical and/or biochemical hyperandrogenism. Chronic autoimmune thyroiditis (AIT) is a common disease of organ-specific autoimmunity affecting predominantly women, that is attributed to an interaction between a genetic background and environmental factors. There are few data showing higher AIT prevalence in PCOS patients.<p...

Introduction: Graves’ disease (GD) is a common autoimmune endocrinopathy where autoantibodies that activate TSH receptor (TRAb) cause clinical hyperthyroidism. Graves’ Orbitopathy (GO) is one of the major complications of GD that results from the inflammation of retro-orbital tissues. Although the clinical usefulness of TRAb determination in the diagnosis of GD is well established, recent studies have shown that TRAb levels may also be helpful in assessing the activi...

Background and patients: The clinical significance and management of papillary thyroid microcarcinoma (PTMC) is widely debated. The objective of this study was to assess the clinical presentation, tumor characteristics and the outcome of the disease in patients with PTMC. In this retrospective study we evaluated 286 patients who were followed for a minimum of three years.Results: Of the 286 patients with a mean age 48.9 years, 226 (79%) were females. Two...

HDR syndrome (hypoparathyroidism, deafness, renal dysplasia syndrome) is a rare clinical entity, which includes the simultaneous presence of hypoparathyroidism, sensorineural deafness and renal dysplasia. It is due to mutations of GATA3 gene in XP.10p and is inherited with the autosomal dominant type.The aim was to describe the case of a patient with clinical symptoms and laboratory and imaging findings compatible with HDR or Barakat syndrome.<p clas...