Endocrine Abstracts

Background: Subclinical autonomous cortisol hypersecretion is the most common hormonal abnormality in patients with adrenal incidentalomas, which is characterized by subtle abnormalities of the hypothalamic–pituitary–adrenal axis (HPA) due to adrenal autonomy. Possible detrimental effects of subclinical hypercortisolism in these patients are still under investigation.Objective: To investigate the prevalence of the metabolic syndrome (MS) in pat...

Introduction: Partial androgen insensitivity syndrome (PAIS) is a heterogeneous group of intersex disorders arising from tissue resistance to androgen action due to mutations of the androgen receptor. The phenotypic expression of the syndrome varies considerably and external genitalia’s masculinization depends on residual activity of the androgen receptor while gynecomastia is observed in most of the cases.Case report: We present the case of a 16 ye...

Background & aims: Impaired glucose tolerance and diabetes as well as cardiac dysfunction are known complications in homozygous beta-thalassemic transfused patients due to iron overload. We aimed to study pancreatic alpha and beta-cell function in regularly transfused patients with homozygous beta-thalassemia and to investigate if cardiac dysfunction may correlate with the development of impaired glucose metabolism.Methods: An oral glucose tolerance ...

Background: Hormonal studies have detected subtle abnormalities of the hypothalamic–pituitary–adrenal (HPA) axis due to autonomous cortisol secretion, in a percentage of patients with adrenal incidentalomas, a condition termed as subclinical Cushing’s syndrome. The diagnostic criteria and the clinical significance of this condition are still controversial and consequently there is uncertainty for its management. Data defining the natural course of these tumors, ...

Background and aims: It is well recognized that insulin resistance and type 2 diabetes (T2DM) are associated with an increased risk for cardiovascular disease especially in women, while the role of sex steroids is still controversial. Women with polycystic ovary syndrome (PCOS) represent a unique biological model for the study of the impact of all these factors on cardiovascular system. We aimed to evaluate the degree of low-grade inflammation and atherosclerosis in premenopau...

Background and aims: Polycystic ovary syndrome (PCOS) and the metabolic syndrome (MS) have many features in common and may share the same pathogenesis. We examined the prevalence of the MS according to the ATP III criteria and the effect of family history for DM 2 on metabolic profile in young women with PCOS.Subjects and methods: We studied 75 women with PCOS aged (23.9±5.4) and 75 healthy age-matched women. We measured BMI, WHR and blood pressure ...

Introduction: Type 2 diabetes mellitus (T2DM) and osteoporosis may co-exist in the same individual. However, the exact effect of anti-osteoporotic treatment on glucose metabolism is unknown. We aimed to systematically review the effects of anti-osteoporotic medications on glucose metabolism and the incidence of T2DM.Methods/design: PubMed, Cochrane and EMBASE were systematically searched until the 31 of December, 2017.Results: ...

Introduction: The aim of this study was to investigate the degree of atherosclerosis in women of reproductive age with type 2 diabetes mellitus (T2DM), with and without polycystic ovary syndrome (PCOS).Patients and Methods: 71 women (mean age 43.2 y) with T2DM treated with diet or oral anti-diabetic medications and 36 controls were studied. According to menstrual cycle and clinical hyperandrogenism, patients with T2DM were classified into two subgroups, ...

Introduction: Polycystic ovary syndrome (PCOS) is usually accompanied by abdominal obesity and insulin resistance which are related with low-grade chronic inflammation, as evidenced by elevation of multiple markers of inflammation, among which is oxidative stress. However, as far as oxidative stress presence, the existing data are limited. The purpose of this study was the investigation of several oxidative stress markers in women with PCOS without insulin resistance.<p cl...

Objectives: • PCOS is defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders.• Women are exposed to increased risk for cardiovascular disease, hypertension, type 2 diabetes mellitus and other metabolic complications• Cardiovascular disease (CVD) is one of the most common cause of mortality wor...