Endocrine Abstracts

Background: Recently many authors are questioning the existing of elements of metabolic syndrome (MetSy) in patients with subclinical hypothyroidism (SH). In this cross sectional study we observed glycemia, as an element of MetSy, in newly diagnosed patients with SH.Materials and methods: Seventy females participated in study. Among them there were 50 patients with SH, mean age 58.3 (±8.53), and 20 controls without SH, mean age 51.1 (±6.79). We...

Background: Serum paraoxonase-1 (PON-1) activity is decreased in clinical conditions associated with low high density-cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation such as in type 2 diabetes mellitus (T2DM). Although many studies have shown that some poly unsaturated fatty acids (PUFA) modulate cardiovascular risk in T2DM, until now there is no data about the association of any fatty acid (FA) with PON-1 activity. This study aims to inves...

Bacground: In type 2 diabetes mellitus (T2DM), the level of polyunsaturated fatty acids (PUFA), is usually decreased, and could be accused for metabolic disturbance, chronic inflammation, and accelerated atherosclerosis. The aim of this study was to determine if there is any relationship between composition of plasma phospholipids PUFAs and parameters of metabolic syndrome.Methods: The study was cross-sectional. Fifteen T2DM patients 63.22±7.20, BMI...

Ganglioneuromas are benign sympathetic tissue tumors originating from neural crest cells. A 40-year-old female patient, was admitted to our department for endocrinological evaluation of incidentally discovered tumor of right adrenal gland. For about a year before admission she had a pain under the right costal arch. An ultrasound and computed tomography (CT) showed 2 ovoid cystical tumors of right adrenal (34 and 32 mm, respectively). Three months prior admission she had sever...

Introduction: By using insulin analogue, it is expected to improve glycemic regulation in poorly controlled type 2 diabetes (t2DM). The aim of the study was to examine the quality of glycemic control and quality of life (QoL) of patients managed with insulin analogues, previously treated with human insulin.Materials and methods: The pilot study included 30 t2DM outpatients, divided into two groups (15 subjects) – the first group was treated with hum...

Background and aim: Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community. The improvement of insulin resistance in hemodialysis (HD) patients is frequently seen after correction of anemia. The aim of this study was to investigate the influence of recobinant humam erythropoietin (Epo) treatment on insulin resistance in non-diabetic HD patients.Patients and methods: We investigated the effects of 6 months-...

Introduction: Cushing’s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free...

Introduction: Subclinical and clinical primary hypothyroidism potentially makes a negative influence on the patient’s quality of life. Present study examined the level of hypothyroid symptoms and signs expression as well patient’s quality of life before levothyroxine and after substitutionally-induced laboratory euthyroidism.Material and methods: Prospective case–control study consisted of 75 female patients divided into three groups based...

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...

Involutive hypoandria (late onset hypogonadism) is characterized by decline in serum testosterone and increase of gonadotropins. Changes of hypothalamo-pituitary-testicular axis sensitivity are influenced by primary testicular changes and altered neuroendocrine regulation during aging. To evaluate age-related changes in gonadotroph and Leydig cell sensitivity two groups were formed: 1) 35 men, 51.8±3.2 years old, BMI=28.2±3.1 kg/m2; 2) 32 men, 63.2±6....