Endocrine Abstracts

Introduction: Isotretinoin (Iso) treatment in acne disease may cause dyslipidemia and increased liver enzymes. Its effects on lipid and glucose metabolism may cause atherogenic complications. The aim of this study was to evaluate carotis intima–media thickness (CIMT), HOMA-IR, and osteopontin (OPN) levels in acne patients on Iso treatment.Methods: Iso treatment given 21 patients are included in this study. They followed for 4 months. 21 patients wit...

Background: Adrenocortical carcinoma (ACC) is a very rare but typically aggressive malignancy. About one to three quarters of ACC is functioning with excess hormonal production.Case: A 44-year-old female patient was admitted to out-patient clinic with obesity, oligomenorrhea and abdominal pain. She had central obesity, buffalo hump, and palpable flank mass. Hypertension, transient ischemic attack, and epilepsy history was present.S...

A 67–year-old female patient was transferred to our hospital from a nursing home for high capillary glucose levels and foot ulcer considered as diabetic foot infection. Her past medical history could not be obtained because of mental retardation with unknown etiology and absence of relatives.A purulent foot ulcer sized 4×3 cm was found in right heel. She also had deformities in her hands, feet, and her nose. Peripheral neuropathy was also detec...

Introduction: Mutations on menin gene are associated with multiple endocrine neoplasia type 1.Case report: Thirty-five year-old male patient was admitted to our hospital with history of recurrent syncope episodes for 5 years which were attributed to hypoglycemia. In physical examination, he had obesity and multiple papillamatous skin lesions on his abdominal region. He had no family history of similar symptoms. His laboratory eveluation was consistent wi...

Introduction: Infliximab is a tumour necrosis factor (TNF) α inhibitor and used for the treatment of psoriasis. Herein, we report a case of destructive thyroiditis accompanied by transient thyrotoxicosis resulting from the infliximab therapy for the treatment of psoriasis.Case report: A 57-year-old man suffered from psoriasis and was treated with infliximab therapy for 4 years. Thyroid function tests were normal before infliximab therapy. When the p...

Introduction: Fine needle aspiration cytology (FNAC) has been widely accepted the most accurate, safe and cost-effective method for evaluation of the thyroid nodules. The most challenging category in the FNAC is atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS). Bethesda System (BS) recommends repeat FNAC in that category due to their low risk of malignancy. In our study, we aimed to investigate the malignancy rate of thyroid n...

Introduction: Our objective for the current review was to inquire the thyroid cancer frequency rate within the patients who have had total thyroidectomy procedure for definitive Graves’ disease treatment and to evaluate the contribution of the presence of nodules to malignity rates.Materials and methods: The present study was conducted by scanning the data of 214 patients who were applied total thyroidectomy for permanent Graves disease treatment, r...

Introduction: Despite the relation between Type 2 Diabetes Mellitus (DM) and development of malignancy is well known, data on antidiabetic drugs and cancer risk is contradictory. Thesis which have suggested that analogue insulins, especially glargine, increase cancer risk, has not been validated. The present study aimed to evaluate the possible contributions of diabetes durations and medications to the type and course of malignancy in patients with both diabetes and malignancy...

Objective: In our clinic we aimed to assess ultrasonographic and histopathologic data of thyroid nodules of patients with nodular thyroid disease reported their repeated cytologic results as non-diagnostic.Methods: Seventy-five patients with nodular thyroid disease whom their TFNAB results were reported 2–3 times non-diagnostically (due to large nodule, ultrasonographically suspicious nodule, high elastosonographic score or strain index, family hist...

Objective: In the Bethesda classification (BC), which is used in cytopathologic evaluation of thyroid nodules, follicular lesion of undetermined significance (FLUS) does not involve sufficient cellular atypia for follicular neoplasia or malignancy, while it doesn’t comprise the cytologic benign criteria. Therefore, there is no consensus for those nodules to follow-up and therapeutic approaches. In this study, we aimed to determine the ultrasonographic features and histopa...