Endocrine Abstracts

Thyroid Associated Ophtalmopathy (TAO) is considered one of the most difficult pathologies to treat and a big threat for Graves Disease (GD) patients. This has enhanced the interest in finding a marker that can predict the onset and the prognosis of TAO. It has been demonstrated that GD is a chronic inflamed tissue that there is a remodelling of the ECM structure which elaborate inflammatory signals itself and also promotes the recruitment of cells from the bloodstream; these ...

Background: Bariatric surgery has been shown to decrease insulin requirements even before significant weight loss has occurred. We report a patient with marked improvement in glycemic control despite modest weight loss post bariatric surgery.Case presentation: A 47 years old Chinese man with obesity (weight 90 kg, BMI 31.2), hypertension, hyperlipidemia and type 2 diabetes mellitus diagnosed in 2005 is on follow up with our endocrine clinic. Despite comp...

Introduction: Adrenocortical carcinomas (ACC) are rare and frequently aggressive tumors that may be functional (hormone-secreting) – causing Cushing’s syndrome and/or virilization, or nonfunctional – presenting as an abdominal mass or as an incidental finding. We describe a rare case of stage IV adrenocortical carcinoma which first manifested as treatment resistant Cushing’s syndrome.Case report: In september of 2021, a 24-year-old fe...

Introduction: Weakness is one of the most common complaints among the patients. Clinical manifestations of a hypopituitarism depend on the extent of hormone deficiency and may be non-specific and thus the diagnosis is often missed. The progressive loss of pituitary hormone secretion is usually a slow process, which can occur over a period of months or years.Clinical case: A 62 years old women who complained of mild weakness mostly in the evenings in the ...

: Two-way interactions between thyroid and kidney functions are known. Chronic kidney disease (CKD) is accompanied by changes in synthesis, secretion, metabolism, and elimination of thyroid hormones, increased risk of hypothyroidism, rarely subclinical hyperthyroidism, whereas thyroid dysfunction affects physiology of the kidney, renal blood flow, glomerular filtration rate (GFR), tubular function, metabolism of water and electrolytes, and kidney structure. The aim of the stud...

Introduction: Thyrotoxic periodic paralysis (TPP) is very rare (prevalence in non-Asian populations 0.1–0.2%, more frequent in men) and potentially life-threatening complication of hyperthyroidism. TPP develops when thyroid hormones cause sodium-potassium-adenosine triphosphatase (Na/K-ATPase) pump overactivity, leading to rapid potassium shift into the cells resulting in hypokalaemia. This causes transient episode of muscular weakness usually involving lower limbs and hy...

Background and aims: GLP1 agonists are used in UAE for diabetes and obesity management (prevalence of 19 and 74% respectively). Few outcome data on GLP1 agonist therapy in this population is available. We investigated the effects of two commonly used GLP1 agonists on weight and HbA1c among UAE patients with diabetes.Materials and methods: Data was retrieved from a computerized database of patients attending a large diabetes center in UAE. Patients on exe...

Fluid restriction (FR) is the recommended first-line treatment for chronic hyponatraemia due to syndrome of inappropriate antidiuresis (SIAD) in expert guidelines, despite the lack of prospective data to support its efficacy. We aimed to test the hypothesis that FR was more effective than no treatment. 46 patients with chronic SIAD were randomised to either fluid restriction (1 litre/day, FR) or no specific hyponatraemia treatment (NoTx) for one month. Inclusion criteria were ...

Background: Studies suggest that diabetes mellitus (DM) is associated with greater risk of developing severe forms of COVID-19 and mortality.Aims: To compare clinical characteristics and outcomes in hospitalized COVID-19 patients with and without DM.Methods: A single-center, retrospective, observational study included adult patients with laboratory-confirmed COVID-19 treated at VUHSK between 2020-01-01 and 2021-03-31. Patients were...

Hyperprolactinaemia is a common endocrine disorder. Causes are related to physiological factors, pharmacological intervention and pathological conditions. There are a wide variety of drugs that can induce a significant hyperprolactinaemia frequently associated with clinical symptoms. The aim was to analyse clinical manifestation of hyperprolactinaemia in routine clinical practice.Material and methods: We conducted retrospective review of medical records ...