Endocrine Abstracts

Introduction: In addition to its role in phosphocalcic metabolism, the vitamin D (vitD) seems to have anti-tumor effects, particularly in colorectal cancer (CRC). The active metabolite of vitD [1,25(OH)2D3], converted by the enzyme CYP27B1, inhibits proliferation and promotes differentiation of CRC cells which express vitamin D receptor (VDR) via the regulation of a high number of genes. The vitD metabolism seems also to regulate inflammatory processes in...

Introduction: Acromegaly is a quite rare and insidious disease caused by the oversecretion of growth hormone and subsequently insulin - like growth factor 1. Recent studies have demonstrated an increased co-existence of different thyroid lesions with acromegaly. However the data concerning this co-occurrence remains a matter of debate. The purpose of this study is to shed light on the different thyroid lesions concerning the patients with acromegaly who are followed up in the ...

Introduction: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of non-insulin-dependent diabetes that classically presents in a lean individual with non ketotic hyperglycaemia and an autosomal dominant inheritance pattern. The diagnosis remains a challenge and may be made by careful clinical evaluation, but exact sub-typing is possible only by genetic analysis.Materials and methods: This is a prospective data analysis in the diabetology-en...

Introduction: Graves’ disease is a common autoimmune disease that can be complicated by orbital damage sometimes threatening the visual prognosis. We report the case of a patient with Graves’ orbitopathy and we discuss the difficulties of clinical evaluation and therapeutic management.Case report: A 68-year-old woman presented to our department complaining of eye protrusion and progressive vision reduction in both eyes. She has had a history of...

Introduction: Acromegaly is a rare chronic, and disfiguring endocrine disorder characterized by growth hormone excess, that carries a significant burden of cardiovascular morbidity and mortality; and still unfortunately one of the most important cause of death in acromegaly. The purpose of this study is to describe the cardiovascular events and risk factors concerning patients with acromegaly who are followed up in the endocrinology department of Oujda’s Mohammed VI unive...

Introduction: Diabetes mellitus is a major public health problem affecting all ages worldwide. In Tunisia, 18% of the population has diabetes mellitus. In fact, it is one of the first ten causes of death in our country.Therefore, self-management education for diabetic patients play an important role in reducing diabetes complications and mortality rate. The education is conducted not only by doctors, but also by nurses.Purpose: The aim of this study is t...

Introduction: Myasthenia gravis (MG) is a chronic neuromuscular condition characterized by weakness in voluntary muscles. It is an autoimmune disorder. The emergence of the condition can be abrupt. As with any autoimmune disease (AID), it may be associated with other AIDs. We report a case of MG associated with Hashimoto’s thyroiditis (HT).Observation: The diagnosis of MG was established in a 58-year-old patient, based on the progressive onset of fa...

Introduction: Nodular thyroid pathology is very frequent. Its exploration requires a clinico-biological evaluation, a cervical ultrasound to look for the ultrasound criteria of malignancy allowing to classify the thyroid nodules according to the EU-TIRADS classification in order to orientate the diagnosis and to indicate the Fine needle aspiration, to finally allow a targeted management. The aim of our study is to investigate the correlation between the EU-TIRADS classificatio...

Introduction: The XX male syndrome occurs in 1 in 20,000 births. This syndrome results from crossover between the X and Y chromosomes, which transfers the sex-determining region of the Y chromosome to the X chromosome. They lack the azoospermia factor region of the Y chromosome, which is essential for spermatogenesis; thus causing infertility.Case Description: 34-year-old gentleman was referred to endocrinology clinic for infertility and semen analysis s...

There is no doubt that AVS plays a central role in differentiating PA subtypes and that adrenalectomy is only indicated in patients with unilateral aldosterone hypersecretion.However, AVS is not widely available. It is invasive and not devoid of morbidity (pain, adrenal hematoma). Cannulating the two adrenal veins is technically demanding and may fail in up to one patient in four. The procedure is not standardized (sequential or simultaneous bilateral AV...