Endocrine Abstracts

Aim: Determine the state of the kidneys by the concentration of blood creatinine in patients with type 2 diabetes in post-EVRP.Materials and Methods: Patients with type 2 diabetes who underwent EVRP were included in the 1st stage of the study. 2 groups of patients: in whom CI-AKI developed in the post-procedural period (29 patients) and patients with an uncomplicated course of the post-procedural period (27 patients).Results: In pa...

Diabetic foot syndrome (DFS) is currently considered the most severe of all late diabetes complications, resulting in deteriorating health outcomes, increased disability and reduced life expectancy.Aim: To study the frequency of occurrence of DFS in rural peoples with diabetes in Uzbekistan.Methods: Upon the international project WDF08-379 ‘Prevention of lower limb amputations in people with diabetes in Uzbekistan’, imple...

Backgrounds: Diabetes mellitus is a complex disease accompanied by the development of complications. In addition to the classic hyperglycemia and dyslipidemia, a number of other factors are involved in the pathogenesis of complications. Plasmalogens disturbances participates in nerve tissue degeneration.Materials and methods: In 76 people with DM2 plasma and erythrocytes membranes plasmalogenes measured and compared according to diabetic neuropathy.<...

Aim: The work was initiated to study TNF-α gene polymorphism and parameters of oxidative stress in patients with type 2 diabetes mellitusMaterials and methods: We examined 41 healthy subjects and 20 patients with diabetes mellitus to study G308A (rs1800629) polymorphism in TNF-α gene by means of allele-specific PCR method (AS-PCR). Rates of lipid peroxidation (LP) were determined by concentration of malon dialdehyde (MDA); catalase activity was...

According to the findings from the recent studies, the oxidative stress can be a cause for type 2 diabetes mellitus onset. In that context, the development of drugs with antioxidant effect to be used for prevention and treatment of the disease is of vital importance. The work was initiated to study the oxidative stress in the experimental diabetes and methods of its correction by means of natural antioxidants. In our study we used polyphenols isolated from the seeds of common ...

Phytotherapy is the integral part of the combined treatment for diabetes mellitus. A large number of plants possessing hypoglycemic activity are described in the literature, but only small part of them is in use. Hypoglycemic effect of medicinal plants is preconditioned by the wide spectrum of compounds with biological activity in their composition. Flowers of carthamus (Carthamus tinctorius) and leaves of celery (Apium graveolens) are known to possess a numb...

Obesity is considered as a major factor of insulin resistance and diabetes mellitus risk. Study on lipid composition of tissues in obesity is relevant in understanding of mechanisms underlying insulin resistance.Aim: The work was initiated to study lipid composition of liver and skeletal muscles tissues in rats with alimentary obesity.Materials and methods: Obesity was induced in rats leading an inactive lifestyle with prolonged hi...

Sphingolipids constitute the structural base for all types of biological membranes, and are numerous in human and animal tissues. Metabolites of sphingolipids act as biological effectors, modulators and mediators in a number of biochemical processes; they are known to be pathogens in various human pathologies.We aimed at studying activity of sphingomyelinase, concentrations of sphingomyelin and its metabolites, such as ceramide and sphingosine, in organs...

Disturbance in insulin signaling under effect of sphingolipids is thought to be the mechanism underlying the obesity-mediated insulin resistance. The work was initiated to study sphingolipid metabolism in tissues of rats with obesity induced by a prolonged high-calorie diet. The lipid extraction and purification was performed by Folch’s method; concentrations of sphingosine and ceramide were measured by Lauter et al. method. In obesity, the levels of total gangli...

Associated with the increased generation of free radicals and reduced activity of antioxidant system, oxidative stress is a pathogenetic mechanism underlying the onset of diabetic complications. Antioxidants are known to facilitate normalization of lipid peroxidation, composition, structures and functions of biological membranes. Antioxidants are universal membrane-trophic agents protecting against damaging factors. Plant antioxidants play a significant role in treatment of di...