Endocrine Abstracts

Introduction: Osteoporosis is a frequent complication associated with primary hyperparathyroidism (PHPT), and surgery is the most effective treatment once established. However, many patients are not candidates for it, and different medical options have been investigated. We aimed to assess the efficacy of denosumab (DMAB) in increasing bone mineral density (BMD) and preventing PHPT-related complications.Methods: Case-control study defining cases (Group 1...

Epidemiological studies have shown that caffeine increases plasma SHBG levels and also reduce the risk of type 2 diabetes. There are no reports describing any molecular mechanism by which caffeine regulates hepatic SHBG production. The aim of the present study was to explore whether caffeine regulates SHBG production and to determine the associated molecular mechanisms. For this purpose, in vitro and in vivo studies were performed using human HepG2 cells and ...

Background: Brown adipose tissue (BAT) plays a pivotal role in the regulation of energy homeostasis and thermogenesis. This tissue responds to insulin, favoring the expression of uncoupling protein-1 (UCP-1), that in turn is inhibited by insulin-desensitizing cytokines. Leptin may abolish some of the effects of fasting on these parameters through its cross-talk with insulin-related signaling targets.Objectives: We hypothesized that leptin infusion preven...

Background and aims: Periodontal disease (PD) is a chronic inflammatory condition where the key feature is the alveolar bone loss. Diabetes mellitus is a major risk factor in the occurrence of PD and vitamin D has been found to play a role in the development of diseases such as PD for its immunomoduratory and anti-inflammatory effects. The purpose of this study was to evaluate the relationship between PD and vitamin D levels in type 1 diabetic patients.S...

Background and aims: Primary hyperparathyroidism (PHPT) often presents without classical symptoms such as overt skeletal disease or nephrolithiasis. Treatment strategies have been widely discussed. The objective of our research was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on skeletal outcomes such as bone mineral density (BMD).Subjects and methods: A retrospective observational study was conducted between 1991 and 2014...

Background and aims: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with different epidemiological patterns among countries. The incidence of PHPT is unknown in Spain. The aim of our study is to assess the prevalence and incidence of diagnosed PHPT in adults between 1970 and 2014 in Santander, a population of 290.000 inhabitants, located in the north of Spain.Subjects and methods: All patients diagnosed with primary hyperparathyroidism...

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Aim: Obesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Bariatric surgery (BS) is an effective means of weight reduction in severely obese patients and correlates with improvements in neurocognition. The mechanisms underlying these improvements are not fully elucidated.Material and Methods: Prospective, observational study, including consecutive patients that ...

Objective: To evaluate the effectiveness and security of bariatric surgery in metabolically healthy obese (MHO).Methods: A retrospective study of a cohort of all obese patients who underwent to bariatric surgery with a minimum two-year follow-up. Databases of all demographic, anthropometric and metabolic characteristics have been collected since 2007. Patients undergoing two surgeries were excluded. We defined as MHO patients those without diagnosis of d...

Sex hormone-binding globulin (SHBG) is a circulating plasma glycoprotein produced by the liver, which in the blood binds estrogens and androgens with high affinity and regulates its bioavailability. Low plasma SHBG levels are associated with obesity, metabolic syndrome and non-alcoholic fatty liver disease. Importantly, epidemiological studies have demonstrated that low plasma SHBG levels is a risk factor for developing type 2 diabetes and cardiovascular disease. In the last y...