Endocrine Abstracts

Aim: The aim of our study was to compare the clinical profile of type 1 and type 2 diabetic patients who are hospitalized in our service for diabetic ketoacidosis.Methodology: This was a descriptive study involving 121 diabetic patients hospitalized for diabetic ketoacidosis in the C department of diabetology of the national institute of nutrition of Tunis.Results: Of the 121 subjects studied, 57.85% are type 2 diabetic patients an...

Introduction: Pituitary Stalk Interruption syndrome (PSIS) is a congenital anomaly of the pituitary gland responsible for isolated or combined anteropituitary insufficiency. We report a case of Pituitary Stalk Interruption Syndrome (PSI) diagnosed in a newborn with profound hypoglycemia.Case report: We report the case of a newborn with hypotonia, neonatal jaundice associated to a micropenis and a bilateral cryptorchidia. Because of severe hypoglycemia at...

Case: A 46-year-old woman presented to the gynaecology department with secondary amenorrhoea, hirsutism and acne. At the age of 25, she was diagnosed with Von Hippel–Lindau disease (VHLD) on the basis of multiple right retinal haemangioblastomas. Investigation revealed an elevated testosterone 13.4 nmol/l (0.3–2.6 nmol/l), 17 hydroxyprogesterone 18 nmol/l and free androgen index 53.6 (0.0–7.5). A solid lesion in the left ovary was demonstrated on ultrasound scan...

Introduction: Pheochromocytoma is an endocrine tumor developed in the chromaffin cells of the adrenal medulla and excessively secreting catecholamines in varying amounts and types. It represents a rare tumor, often benign, but serious considering its mainly cardiovascular complications. The purpose of our study is to specify the revelation methods of pheochromocytomas in our population.Patients and methods: Our study has included 23 cases of pheochromocy...

Introduction: Malignant pheochromocytomas present a real challenge for practitioners. This entity of tumors is rare, with complex characterization, and heterogenocity in their evolution and prognosis. Given the rarity of this tumor group, there is no consensus on the therapeutic management. The management must be in a multidisciplinary framework. Through this illustrative case, we propose a literature review of this rare entity with discussion of the different therapeutic opti...

Introducing: Primary hyperparathyroidism (HPT1) is a frequent endocrinopathy. Diagnosed incidentally or in front of a urinary or bone symptomatology, we report a case of primary hyperparathyroidism in the mode of revelation makes the originality “a paralyzing sciatica”.Observation: The patient was 44 years old and was undergoing neurosurgery for chronic low back pain that was resistant to etiological treatment. In view of the persistent and hyp...

Introduction: The HAIR-AN syndrome, which consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN), is an underdiagnosed endocrinopathy.Observation: We report the case of Miss A.M., 24 years old, admitted for exploration of hyperandrogenism. Anamnesis: the patient reported polyuropolydipsic syndrome and the notion of weight gain without eating disorders, making a total of 28 kg in 6 months. This period is also marked by th...

Introduction: Kallmann syndrome (KS) is a rare disorder. It is now designated as olfactogenital dysplasia with an association between agenesis of the olfactory bulbs and hypogonadism. The association of KS with a pituitary microadenoma has not been well described in the literature.Case report: It’s a 16-year-old and 6 months, admitted for evaluation of a micropenis, he has as ATCDs an orchidopexy performed at the age of 3 years, infertility in the m...

Systemic lupus erythematosus is a serious autoimmune disease characterised by the production of antinuclear antibodies directed particularly against native DNA. Its presence increases the susceptibility to develop other autoimmune diseases including autoimmune dysthyroidism. We present the case of a patient who presented with profound hypothyroidism as part of the work-up for lupus nephropathy. Female patient, 40 years old, reports physical asthenia for 2 months. On clinical e...

Introduction: -Thyroid disorders can predate or develop during pregnancy. -The effects on the fetus vary depending on the disease and the drugs used for treatment. But usually, untreated or undertreated hyperthyroidism can lead to harmful complications.Case report: It’s a 26-year-old patient with a history of goiter since childhood, history of goiter in the mother; grandmother and maternal aunt. the patient is 18 weeks pregnant, the pregnancy is unp...