Endocrine Abstracts

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. Generally, PTC is an indolent disease and shows a good prognosis in most patients. However, up to 30% of patients have local tumor renewal or systemic spread. It is crucial to identify patients with a high risk of disease progression. DNA methylation biomarkers may provide clinically valuable information and improve ...

Introduction: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer (85%–90%). Today Fine needle aspiration biopsy (FNAB) is the diagnostic tool for the evaluation of thyroid nodules because of its accuracy and cost-effectiveness, but FNAB also has limitations, as it is quite challenging to take a biopsy from a small thyroid nodule moreover FNAB diagnosis is doubtful in up to 20% of cases. Therefore, non-invasive biomarkers of PTC are needed.<p clas...

IntroductionPituitary diseases result in clinical consequences and increased mortality due to tumors mass effects and also due to pituitary hypersecretion and insufficiency. Pituitary tumors registry enables identification of diagnostic and prognostic markers. The registry improves long-term clinical outcomes, pituitary diseases care and management.The aim of this studyOur registry study is designed to create...

Objective: Primary hyperparathyroidism is the third most common endocrine disorder, which often causes hypercalcemia in outpatient cases. This study aimed to evaluate the various demographic and clinical characteristics, biochemical data, as well as the prevalence of associated conditions, diagnostic accuracy of imaging modalities, and treatment outcomes in patients with APHPT.Methods: We analyzed data collected from 168 individuals diagnosed with APHPT ...

Introduction: Insulinoma is a rare pancreatic tumor, typically sporadic, solitary and benign. However, nonspecific symptoms of hypoglycemia, negative laboratory investigations and small size of these tumors can retard the diagnosis, and symptoms may be misattributed to psychiatric, cardiac, neurological disorders.Case presentation: A 35-year-old male had history of night time seizures with hallucinations, delirium and spasms, lasting from 10 minutes to 1...

Background: Heterozygote familial hypercholesterolemia (HeFH) is a common genetic disorder resulting in high low–density lipoprotein–cholesterol (LDL–C) levels. It has been established that only 3% of patients (pts) among the Latvian population were diagnosed in 2019. The early HeFH diagnosis and treatment can prevent premature cardiovascular complications and save lives. Aim. The study aimed to determine the incidence of HeFH in a single-centre endocrinologist&...

Introduction: Diabetic nephropathy (DN) is a severe complication of type 1 diabetes mellitus (T1DM) and has become common primary disease leading to end-stage renal disease worldwide. Abnormalities in lipid metabolism is very important in the progression of renal damage in patients with T1DM.Aim: to assess the relationship between lipid abnormalities and diabetic nephropathy in type 1 diabetes mellitus patients. Methods: we perform...

Objective: Pregnancy in women with type I diabetes mellitus (T1DM) is associated with an increased risk of various obstetric complications. The purpose of this study was to evaluate relation of HbA1c, delivery age and various diabetes aspects on pregnancy outcome and gestation in women with T1DM.Methods: This was a cross-sectional study. A total of 48 women hospitalized to the Hospital of Lithuanian University of Health Sciences Kauno klinikos Endocrinol...

Background: Diabetic neuropathy (DN) is a major complication of diabetes, affecting one in three people with diabetes. The presence of peripheral neuropathy increases their risks of developing foot ulceration and subsequent necrosis that results in lower limb amputation. Good diabetes control helps to lower the risk of diabetic complications, which can be accelerated by advanced glycation end-products (AGEs) or alcohol consumption. AGEs are heterogeneous group of molecules, th...

Introduction: 45,X karyotype is known to be related to more severe phenotype disorders, still comparative analysis of the karyotypes and phenotypes in Turner syndrome (TS) is difficult, even in the largest studies, mainly due to differences in patient‘s age and variability in the definition of clinical features (1). We aimed: to assess if monosomia in Turner syndrome patients is related to their cardiometabolic features.Methods: 75 females with conf...