Endocrine Abstracts

Background: Struma ovarii is a rare form of the ovarian germ cell tumors composed predominantly of mature thyroid tissue. It occurs mostly in the fifth decade. About 5–10% of these tumors are malignant. We present the case of a 20-year-old-woman with papillary thyroid carcinoma arising in struma ovarii.Case report: A 20-year-old woman presented to her gynecologist with pelvic pain. A right ovarian tumor was discovered at ultrasound examination. The ...

Background: NETs are rare tumours arising from dispersed neuroendocrine system. Nevertheless, their estimated prevalence increased lately, mostly due to progress in imaging, biochemical and histopathological diagnostics.The aim of the study was to present the characteristics of the NETs patient surveyed in our Endocrinology Department since 2000.Material and methods: One hundred and fifty-eight patients (males – 42.4%, females...

Ghrelin is a somatotrophic, orexigenic and adipogenic hormone that has an important homeostatic role by linking regulatory systems for growth and energy balance. Ghrelin- secreting neuroendocrine tumors are rare, but we had the opportunity to study a 71 years old female patient with a gastric ghrelinoma. The patient was submitted to gastroenterological examination after having episodes of diarrhea, and small subepithelial polyp (5 mm) was revealed on gastroscopy. Pathohystolog...

Cortisol rise during pregnancy is connected with fetal maturation. Together with the increase of insulin resistance it might have a role in allocation of nutrients between mother and fetus. Cortisol and insulin secretion during pregnancy seems to be induced by fluctuations in BMR. Here, we try to identify relationship between BMR and secretion of cortisol and insulin during pregnancy.In 25 healthy women (age range 20–39 years; mean±S.D.<...

It was postulated that different therapeutic approaches could influence the markers of inflammation in obesity but it is unknown whether overweight women with and without metabolic syndrome have the same degrees of inflammatory state. The aim of our study was to compare level of hs-CRP in obese women without other components of metabolic syndrome with hs-CRP in women with metabolic syndrome (according IDF criteria). Overweight body mass index-matched women without (OW)) (n<...

Aim of the study was1. To assess the thyroid function in pregnancy in the course of effective iodine prophylaxis model introduced in 1997, based on obligatory salt iodization.2. To exam glucose tolerance and insulinemia in pregnancy.Methods: TSH, fT4, aTPO, urine iodine concentration, usg thyroid volume and homogeneity, glucose and insulin during OGTT, blood pressure, BMI, and thyroid function and glucose met...

Introduction: Neuroendocrine tumors secreting ACTH are a rare cause of Cushing’s syndrome.Diagnostic and therapeutical difficiulties might be caused due to different clinical picture of of neuroendocrine tumors.Patients, diagnostic and therapeutic approach: During 2004–2005 2 female patients 32-years old AL and 67-years old ZS were hospitalized in Endocrinology Department due to severe hypercorticism signs and symptoms. I...

It was speculated that androgen levels and insulin resistance may have influence on ghrelin levels. Elevated, normal and low ghrelin levels were reported in women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the basal ghrelin levels in lean patients with PCOS and to evaluate possible correlations between ghrelin levels, insulin resistance and, androgen levels. In 10 lean PCOS patients (BMI 20.45±0.51 kg/m2, age: 21.4±0.85 ...

Introduction: Obesity is often accompanied by comorbidites predisposing atherosclerosis. Carotid intima-media complex thickness (CIMT) is consisdered as a marker of initial asymptomatic atherosclerosis. The relationship of sex hormones to obesity and atherosclerosis has been extensively studied.Objective: The objective of the study was to analyze the correlation CIMT and sex steroid levels in severly obese pre-menopausal women.Meth...

BackgroundSilent somatotroph pituitary tumours are very rare, representing only 2-4% of all pituitary tumours in surgical series. Little is known about the course of the disease and efficacy of possible treatment modalities.Presentation of the caseA male, born in 1990, was first admitted to the hospital at the age of 15, due to sudden ptosis of the right eye and headaches, present for 1 year before the diagno...