Endocrine Abstracts

To date only seven cases of naturally occuring inactivating mutations of the aromatase gene in men have been documented. Osteoporosis is one of the typical signs of the aromatase deficiency in male patients. We report results of estrogen therapy in patient with formerly described frameshift mutation of the CYP19 gene, ins 1058 T. Bone mineral density (BMD) was assessed during three phases of estrogen therapy. Patient was substituted by calcium and vitamin D throughout t...

A 72-year-old depressed woman complained about fatigue, weight gain (20 kilos/2 years), severe and recent hypertension, easy bruises, and venous insufficiency. Whereas she was treated with six antihypertensive drugs, she had hypokaliemia (2.6 mM). Cardiac ultrasounds showed myocardial hypertrophy. A Cushing syndrome was suspected. UFC was increased (400 mM/d), cortisol cycle disrupted and a standard DXM test showed no cortisol suppression (775 nM/l). ACTH levels were consisten...

A 61-year-old man was hospitalized for paresthesias and renal insufficiency (creatinine clearance 24 ml/min) with proteinuria. Type 2 diabetes was diagnosed in 2003 and hypertension in 2007. Hypercalcemia (4.6 mM) with normal phosphorus level 1.23 mM was discovered with very high PTH levels (863 ng/l; N<78). MIBI scintigraphy localized a right inferior parathyroid tumour. No obvious sign favouring MEN1 was observed and no familial case was reported. After a short pa...

Introduction: Turner syndrome is well known, but prognosis for 45,X/46,XX mosaicism under 30% of aneuploidy has not been established. We realised a retrospective study among women aged 21–43 years, to evaluate differences in clinical features and biological parameters between patients who had sex chromosome mosaicism diagnosed incidentally and controls women.Material and methods: Among infertile population, 71 women with sex chromosome mosaicism (45...

Patients with adult onset GHD (AO-GHD) manifest features of the metabolic syndrome (MetS) (abdominal obesity, dyslipidemia and insulin resistance), a condition associated with increased risk of diabetes mellitus (DM).We assessed metabolic status before and after 2 years of GH treatment and the occurrence of de novo DM in 712 patients with AO-GHD from HypoCCS drawn from the US (32.2%) and Europe (67.8%). Patients were divided into four BMI categori...

Introduction: MSC is a simple and reliable mean to diagnose hypercortisolism, yet its value to asses the outcome of treatment has rarely been addressed.Objective: Compare MSC and other classical parameters, to assess the outcome of TSS in CD.Patients and methods: Sixty-eight patients from a single Center operated for CD between 1996 and 2006. Outcome was assessed between 6–12 months post TSS. Remission was defined as: morning ...

Obesity, diabetes, and depression are associated with distinct neuroendocrine changes influencing the regulation of the hypothalamus pituitary adrenal (HPA) system. Up to now it was not possible to examine the central glucocorticoid feedback in humans to verify results of animal experiments in relating disease models. With the help of a recently developed computational approach we were enabled to address this question to patients with obesity, diabetes, or depression.<p cl...

Acute suppurative thyroiditis is a rare disease because thyroid gland is highly resistant to infection. The most common predisposing factor is the presence of a piriform fistula. We report an unusual case of hyperthyroidism caused by AST.A 27-year-old woman was admitted to our hospital because she presented a painful swelling in the left thyroid gland with fevers. Laboratory test showed a white leukocyte count of 14 000/μl, a CRP level of 251 mg/l, ...

Context: Weight loss and metformin therapy are beneficial in improving the hormonal and metabolic consequences of PCOS. Rimonabant has been found to reduce weight and improve the metabolic profile in patients with metabolic syndrome.Objective: To compare the effects of metformin and rimonabant on insulin resistance and biochemical hyperandrogenemia.Subjects: Twenty patients with PCOS and biochemical hyperandrogenemia were recruited...

Context: Rimonabant has been found to reduce weight and improve the metabolic profile in patients with metabolic syndrome as well as PCOS.Objective: To compare the effects of metformin and rimonabant in patients with PCOS with and without metabolic syndrome according to ATP III criteria.Design: A randomised open labelled parallel study comparing the effects on rimonabant and metformin in patients with PCOS.Su...