Searchable abstracts of presentations at key conferences in endocrinology

ea0081p453 | Reproductive and Developmental Endocrinology | ECE2022

Crosstalk between androgen-ZIP9 signalling and key regulators of mitochondrial dynamics in rodent leydig cells

Brzoskwinia Małgorzata , Kamińska Alicja , Lustofin Sylwia , Hejmej Anna , Bilińska Barbara

Androgen signalling plays a central role in the regulation of male reproduction. Androgens act predominantly by activating the classical intracellular androgen receptor (AR). In addition, alternative pathways may account for rapid effects of androgens via cytoplasmic or membrane-localized androgen receptor − ZIP9. In the testis, the main source of androgens, in particular testosterone, are Leydig cells. The proper synthesis of testosterone depends on the structural condi...

ea0081ep1208 | Late Breaking | ECE2022

Biological profile of patients with Graves’ disease after treatment with iodine 131: experience of the nuclear medicine department of Tlemcen hospital

Nour El Houda Khelil , Mohammed Meghelli Sidi , Zohra Benmansour Fate ma , Nassima Bouhadjer

Hyperthyroidism is a clinical situation characterized by an excess of thyroid hormones in the circulation, the most common etiology of which is Graves’ disease. Its treatment is based on ATS, iodine 131 and surgery. The iratherapy, object of our study, is a treatment of current practice. It is a simple and radical treatment whose goal is to switch to euthyroidism or hypothyroidism. In case of failure or recurrence, a 2nd or even a 3rd cure is prescribed. We conducted a re...

ea0089p10 | Population Science | NANETS2022

Environmental Pollution and GEP-NENS – Is There an Association?

Ituarte, PhD Philip H. G. , MA Nora Ruel , MD Daneng Li , MD Gagandeep Singh

Background: Incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEMs) is increasing, but etiology of sporadic, non-familial disease remains obscure. Behavioral risk factors like smoking and alcohol consumption may be associated with GEP-NENs, yet environmental factors potentially associated with GEP-NENs remain unexamined. We regressed age-adjusted incidence rates for GEP-NENs cases in California (CA) on county-level pollution data to determine if an association ...

ea0090p574 | Calcium and Bone | ECE2023

A long and challenging journey from the first non-typical gastrointestinal manifestations to the diagnosis of primary hyperparathyroidism and MEN 1

Kiluk Małgorzata , Łebkowska Agnieszka , Kowalska Irina , Karczewska-Kupczewska Monika

Introduction: Primary hyperparathyroidism (PHPT), as a state of chronic hypercalcemia, can be manifested by non-typical symptoms which can delay the proper diagnosis for many years and lead to serious preventable complications affecting the patient’s quality of life.Case report: A 52-year-old woman with hypertension, thyroid nodular goiter treated with radioactive iodine and a 20-year history of gastric and duodenal ulcerative disease, complicated b...

ea0090p633 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The prevalence of vitamin D deficiency in hospitalized patients with COVID-19 decreased significantly during the pandemic in Slovakia between the years 2020-2022

Smaha Juraj , Jackuliak Peter , Kužma Martin , Max Filip , Binkley Neil , Payer Juraj

Background: The coronavirus disease 2019 (COVID-19) pandemic led to changes in lifestyle, which could influence vitamin D status on a population level. The purpose of our study was to compare 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized because of severe COVID-19 during two waves of the pandemic (2020/21 vs. 2021/22).Materials and methods: We analyzed 101 patients (61 males/ 40 females) hospitalized in the internal medicine department of...

ea0090p464 | Reproductive and Developmental Endocrinology | ECE2023

Visfatin expression and regulation by E2, P4, hCG and insulin in human placental cells

Dawid Monika , Kurowska Patrycja , Pawlicki Piotr , Kotula-Balak Małgorzata , Milewicz Tomasz , Rak Agnieszka

Introduction: Visfatin belongs to adipokines, i.e. hormones produced mainly by adipose tissue; its expression and role have been described in many organs, where it regulates energy metabolism, insulin resistance and inflammatory reactions. Moreover, the level of visfatin changes during pregnancy and in obese women and those with obesity related pregnancy pathologies: preeclampsia (PE), gestational diabetes (GDM) or intrauterine growth restriction (IUGR) its level increases. Th...

ea0063p626 | Interdisciplinary Endocrinology 1 | ECE2019

Autoimmune thyroiditis (AIT) and diet – the patients’ and medical professionals’ view

Trofimiuk-Muldner Małgorzata , Czubek Ewa , Sztorc Jan , Skalniak Anna , Hubalewska-Dydejczyk Alicja

An increasing interest in improving the quality of life of patients with autoimmune thyroid disorders has been noted during recent years. Although there is little scientific evidence, many patient-oriented publications, websites and support groups recommend changes in diet as well as nutritional supplement use as a cure for thyroid disease and the mean for ailments reduction. The presented survey aimed to explore the patients’ and medical professionals’ approach to n...

ea0049ep1 | Adrenal cortex (to include Cushing's) | ECE2017

Confirmatory tests for diagnosis of primary aldosteronism among Chinese hypertensives

Jiang Minchun , Ma Dujuan , Lin Hailun , Lin Ying , Deng Yajuan , Tang Juying , Zhang Shaoling , Guo Ying

Objective: Primary aldosteronism (PA) has emerged as the most frequent form of secondary hypertension. For the diagnosis of PA, confirmatory testing is indispensable and different tests are recommended by guidelines, including captopril challenge test (CCT) and saline infusion test (SIT). However, there are sparse studies evaluating and comparing CCT and SIT in Chinese population. Hence, we investigate the diagnostic efficiency of CCT and SIT for PA in Chinese hypertensives in...

ea0049ep1127 | Female Reproduction | ECE2017

Relationship between steroid hormones and metabolic profile in women with polycystic ovary syndrome

Lazurova Zora , Figurova Jana , Ujhazi Simona , Mašlankova Jana , Toporcerova Silvia , Lazurova Ivica

Background: There is evidence that polycystic ovary syndrome (PCOS) is commonly associated with higher cardiometabolic risk. Aim of the study was to compare various sex streoids in PCOS women with overweight or obesity (BMI >27) and those with lower BMI. Second aim of the study was to determine the relationship of various sexual setroids to cardiovascular risk in PCOS women.Subjects and methods: Study included 64 Caucasian women with PCOS. F...

ea0049ep1173 | Male Reproduction | ECE2017

Gonadal status in males with acute coronary syndrome and the extent of coronary artery disease: a comparative cross-sectional analysis

Bednarova Adriana , Koller Tomaš , Kužma Martin , Payer Juraj

Introduction and aims: Association between coronary artery disease (CAD) and male gonadal status has been previously suggested, but still remains inconclusive. Aims of our study in males with recent acute coronary syndrome (ACS) were to evaluate the prevalence of hypogonadism, to compare their gonadal status with non-ACS matched controls and to evaluate gonadal status by the extent of CAD.Subjects and Methods: A cross-sectional retrospective study includ...