Endocrine Abstracts

Introduction: Tumor necrosis factor alpha (TNF-α) and Interleukin-6 (IL-6) are potent immunomodulators and proinflammatory cytokines displaying varied functions. Apart from monocytes/macrophages, they are also produced by the cells in female reproductive tract. Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorder amongst women of reproductive age group. Several polymorphisms in the promoter region of the gene TNF-α, IL-6 and Leptin receptors ...

Introduction: Graves’ disease (GD) is one of the commonest organ specific autoimmune thyroid disease. Surgical thyroidectomy is one of the definitive treatment modalities. Autoimmunity has been implicated as one of the main cause of GD. In this context, we set out study the role of Pro- inflammatory cytokines in GD.Material and methods: This prospective case-control study was conducted on surgically managed GD patients. Institutional ethical committ...

Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest organ specific autoimmune thyroid disease. Though it is mostly treated medically, certain goitrous forms require surgical thyroidectomy for various indications. Autoimmunity has been implicated as one of the main cause of HT. In this context, we set out study the role of Pro- inflammatory cytokines in HT.Material and methods: This prospective case-control study was conducted on surgi...

Introduction: Contrary to the high prevalence of polycystic ovarian syndrome (PCOS) amongst reproductive age group women, there is disproportionate uncertainity over its etiopathogenesis. Substantial evidence suggests immunological-inflammatory role in causing this endocrine disorder. In this context, we set out study the role of inflammatory biomarkers in PCOS.Material and methods: This prospective case-control study was conducted on PCOS patients diagn...

Introduction: Nodular thyroid disease (NTD) is one of the commonest endocrine disease with incidence ranging from 5–30% in various populations Worldwide. They often require surgery for indications such as pressure symptoms or size related reasons. The natural history and etiopathogenesis are largely unclear except in few endemic regions. Immunomodulatory role has often been implicated in their pathogenesis. In this context, we set out study the association between Pro- in...

Introduction: The adenoma – carcinoma sequence in thyroid nodules is a enigmatic phenomenon. There are conflicting reports on development of papillary cancer from benign adenomas. Genomics is the only definitive modality to resolve this hypothesis. Adenomas and papillary carcinomas tend to have mutations in Sodium Iodide symporter gene (NIS) and highly specific BRAF gene respectively. In this context, we set out study the prevalence of these somatic mutations in surgical ...

Introduction: Papillary thyroid carcinoma (PTC) is the commonest endocrine malignancy. Apart from genetic role in its pathogenesis, autoimmunity has been implicated in certain papers. But, reports have been tripolar ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was...

Introduction: Granulomatous thyroiditis (GT) is one of the various types of autoimmune thyroiditis. It usually occurs in women of reproductive age in perigestational period. Clinical picture in is predominantly painful goiter with radiating pain to ears with low grade fever lasting for few days, sometimes associated with mild hyper or hypothyroidism. The treatment is symptomatic and supportive with no curative option. There are meagre anecdotal reports of thyroidectomy role fo...

Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest endocrine disorder. Often, HT is associated with a plethora of autoimmune co-morbidities (AIC) such as vitiligo, arthitides, pernicious anaemia, skin allergy, thrombocytopenia, addison’s disease, type 1 diabetes, celiac disease, eosinophilia etc., The etiology of these AIC in HT is enigmatically idiopathic and hypothesized to be autoimmune in origin. Many studies suggests that thyroid specific antibod...

Background: Thyroid disorders are the commonest endocrine disorder after diabetes in most of the populations worldwide. Though, hypothyroidism is extremely common in children, there is acute scarcity of genetic studies leading to improper screening and treatment protocols in developing countries. The aim of this ambitious study was to screen for NIS, DUOX2 and TPO mutations in south Indian children and adolescent patients with dyshormogenetic goiter (DH) and Hashimoto’s t...