Searchable abstracts of presentations at key conferences in endocrinology

ea0081p232 | Thyroid | ECE2022

Levothyroxine Replacement Therapy overuse. Factors suggesting treatment discontinuation

Livadas Sarantis , Bothou Christina , Paparodis Rodis , Androulakis Ioannis , Angelopoulos Nicholas , Boniakos Anastasios , Anagnostis Panagiotis , Duntas Leonidas

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

ea0049oc4.5 | Thyroid Disease 1 | ECE2017

Levothyroxine replacement therapy: once treatment is started, should it last indefinitely?

Livadas Sarantis , Bothou Christina , Androulakis Ioannis , Boniakos Anastasios , Angelopoulos Nicholas , Duntas Leonidas

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

ea0035p641 | Female reproduction | ECE2014

Relationship between visceral adiposity index, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with polycystic ovary syndrome

Androulakis Ioannis , Kandaraki Eleni , Christakou Charikleia , Karachalios Athansios , Marinakis Evangelos , Paterakis Thomas , Diamanti-Kandarakis Evanthia

Objective: The clinical phenotype of PCOS includes reproductive and hormonal aberrations. Visceral adiposity index (VAI) is an indicator which could connect hyperandrogenism and anovulation. The objective was to evaluate the relationship between VAI, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with PCOS.Patients: 180 women with PCOS diagnosed with Rotterdam criteria.Measurements: We correlated V...

ea0020p30 | Adrenal | ECE2009

Study of hormonal activity and insulin resistance in patients harbouring incidentally discovered bilateral adrenal adenomas

Androulakis Ioannis , Papanastasiou Lambrini , Tsenilklidi Ermioni , Prevoli Anastasia , Kafritsa Paraskevi , Pappa Theodora , Tsiavos Vaios , Piaditis George

Background: Hormonal activity and insulin resistance (IR) in patients with incidentally discovered bilateral adrenal adenomas (BA) has not been evaluated until now. Therefore, we have investigated cortisol and aldosterone secretion and IR in 29 patients with BA, in 113 patients with unilateral adrenal adenomas (UA) and in 89 healthy subjects (C).Methods: All subjects underwent the following investigation: 1) Low dose dexamethasone suppression test (LDDST...

ea0020p448 | Obesity and Metabolism | ECE2009

Evidence of increased cardiovascular risk in patients with non-secreting unilateral adrenocortical adenomas

Androulakis Ioannis , Kollias George , Markou Athina , Papanastasiou Lambrini , Angnostou Tilemachos , Papamichael Christos , Piaditis George , Kaltsas Gregory

Background: Incidentally discovered adrenal adenomas (AA) are associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance, all established risk factors for cardiovascular (CV) morbidity. However, most studies were performed in patients with AA and autonomous cortsisol and/or aldosterone secretion, whereas the presence of cardiovascular risk in patients with non-secreting AA has not been looked into detail.Methods: Cardio...

ea0084op-06-30 | Oral Session 6: Hypothyroidism | ETA2022

Levothyroxine replacement therapy overuse and factors guiding successful treatment discontinuation: short and long-term observation data of a large cohort

Livadas Sarantis , Androulakis Ioannis , Angelopoulos Nikolaos , Anagnostis Panagiotis , Paparodis Rodis , Boniakos Anastasios , Askitis Dimitrios , Duntas Leonidas

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98 years on LT4Rx witho...

ea0041gp23 | Adrenal (2) | ECE2016

Deterioration of indices of insulin resistance in patients with non-functioning and cortisol secreting adrenal incidentalomas during a long term follow-up

Papanastasiou Labrini , Alexandraki Krystallenia , Fountoulakis Stelios , Kounadi Theodora , Markou Athina , Tsiavos Vaios , Androulakis Ioannis , Samara Christianna , Piaditis George , Kaltsas Gregory

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

ea0041ep545 | Diabetes therapy | ECE2016

Long-term effects of Stevia rebaduiana on glucose and lipid profile, adipocytokines, markers of inflammation and oxidation status in patients with metabolic syndrome

Kassi Eva , Landis George , Pavlaki Aikaterini , Lambrou George , Mantzou Aimilia , Androulakis Ioannis , Giannakou Andreas , Papanikolaou Eleni , Chrousos George

Introduction: Metabolic syndrome (MetS) is a cluster of interconnected factors that directly increase the risk of DM2 and CVD. Stevia rebaudiana (a low calorie natural sweetener) and its compounds are known for anti-hyperglycemic, anti-inflammatory, anti-oxidant, anti-hypertensive effects.Methods: Thirty-eight patients (age 47.3±10.3 years) (nmales=14, nfemales=24) with MetS (NCEP/ATPIII criteria) wer...

ea0022p548 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Evaluation of adrenal morphological and functional alterations in acromegalic patients

Pappa Theodora , Papanastasiou Labrini , Tsiavos Vaios , Tseniklidi Ermioni , Androulakis Ioannis , Tsounas Panagiotis , Roussaki Peggy , Kaltsas Gregory , Piaditis George

Introduction: Acromegaly is well known to induce hypertrophy and hyperplasia in many organs, i.e. thyroid gland, colon, prostate. This action is presumably exerted by the elevated GH and IGF1 levels. In our study, we investigated the alterations of the adrenal glands seen in acromegaly.Aim: To assess the changes in adrenal morphology and functional status in a series of patients with acromegaly.Subjects and methods: Fifty-four acro...

ea0016p39 | Adrenal | ECE2008

Impaired endothelial morphology and function in patients with subclinical Cushing's syndrome due to single adrenocortical adenomas

Androulakis Ioannis , Kollias Georgios , Markou Athina , Gouli Aggeliki , Anagnostou Tilemachos , Stamatelopoulos Kimon , Papamichael Christos , Piaditis Georgios , Kaltsas Gregory

Background: Subclinical CushingÂ’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....