Searchable abstracts of presentations at key conferences in endocrinology

ea0081p367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metformine: anti-fibrotic molecule?

Khelifi Dayssem , Ben Nacef Ibtissem , Bouzid Kahena , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Background and aims: Diabetes causes tissue fibrosis by still poorly understood mechanisms which involve glycation products. Galectin-3 (Gal-3) is an emerging key player in metabolic disorders and a powerful factor in the development and progression of the fibrotic process in target organs in diabetic patients. The plasma level of Gal-3 increases during diabetic cardiomyopathy and diabetic nephropathy. We have studied the correlation between serum Gal-3 level and anti-diabetic...

ea0081ep388 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic muscle infarction : a case study

Maaoui Ons , Mekni Sabrine , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

Introduction: Diabetic muscle infarction (DMI) is a rare complication of long-standing, poorly controlled diabetes, and it’s more common in patients with micro-vascular complications. Herein, we present a case of DMI occurring in patient on hemodialysis.Case presentation: A 44-year-old man on maintenance hemodialysis presented with an acutely painful and swelling in his left calf. He had a 21-year history of poorly controlled type one diabetes, with...

ea0081ep825 | Pituitary and Neuroendocrinology | ECE2022

Binasal hemianopsia with pituitary adenoma in a 15-year-old girl

Kamoun Elyes , Rojbi Imen , Mekni Sabrine , Smadhi Houaida , Lakhoua Youssef , Ben Nacef Ibtissem , Khiari Karima

Introduction: Pituitary adenomas represent 10 to 20% of intracranial tumors. In children, craniopharyngioma are the most common tumor of the sellar region. The symptoms can include headache, vomiting, pituitary deficiency and in pituitary adenomas, hormonal excess. The visual examination can find a visual field defect such as a bitemporal hemianopsia. We present a rare case of a pituitary adenoma in a 15-year-old girl with binasal hemianopsia.Observation...

ea0081ep839 | Pituitary and Neuroendocrinology | ECE2022

Diagnosis of Kallmann syndrome in adulthood

Kamoun Elyes , Mekni Sabrine , Adel Meriem , Rojbi Imen , Ben Nacef Ibtissem , Mchirgui Nadia , Khiari Karima

Introduction: Kallmann syndrome is a rare genetic condition characterized by the association of a hypogonadotropic hypogonadism and anosmia. It results from the failure of GnRH cells to migrate to the hypothalamus and lack of development of the olfactory bulb. The main symptom of Kallmann syndrome is delayed or incomplete puberty usually associated with an impaired sense of smell. We herein describe a case of Kallmann syndrome discovered at the age of 57 years old.<p class...

ea0090ep177 | Calcium and Bone | ECE2023

Maxillary brown tumor revealing primary hyperparathyroidism: A case report

Besrour Chayma , Ben Nacef Ibtissem , Mekni Sabrine , Essayeh Sawsen , Mchirgui Nadia , Rojbi Imen , Khiari Karima

Introduction: Primary hyperparathyroidism is an asymptomatic endocrine disorder in 80% of the cases. The bone manifestation represents the late stage of the disease and the brown tumor represents an exceptional and rare lesion.Observation: We report the case of a 73-year-old patient, with a medical history of type 2 diabetes, followed in the oto-rhino-laryngology department for a gingival tumor. A biopsy was performed and the anatomopathological examinat...

ea0090ep203 | Calcium and Bone | ECE2023

Multiple Endocrine Neoplasia type 1: A case report

Besrour Chayma , Essayeh Sawsen , Mekni Sabrine , Rojbi Imen , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

Introduction: Wermer syndrome or multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disease characterized by the presence of generally benign tumors of the endocrine glands.Observation: We report the case of a 68-year-old patient with a family history of a sister having a primary hyperaldosteronism and a personal history of primary hyperaldosteronism who was referred to our department for the exploration of asymptomatic hypercalcemia. The bi...

ea0090ep581 | Endocrine-related Cancer | ECE2023

A rare association of glucagonoma and gastric gastrinoma

Ben Rebai Senda , Rojbi Imen , Mekni Sabrine , Sawsen Essayah , Ben Nacef Ibtissem , Khiari Karima

Introduction: Glucagonomas are rare functioning pancreatic neuroendocrine tumours that secrete glucagon. Gastrinomas are neuroendocrine tumours that secrete gastrin and are rarely located in the stomach. We report an extremely rare case of concomitant gastric gastrinoma and glucagonoma.Case presentation: A 64-year-old-man with a history of digestive haemorrhage and gastrectomy presented with weight loss, asthenia, anorexia and abdominal pain. Esophagogas...

ea0063p558 | Diabetes, Obesity and Metabolism 2 | ECE2019

Endocrinopathies and diabetes: cardiovascular risk assessment

Khiari Marwa , Ben Nacef Ibtissem , Rojbi Imene , Mchirgui Nadia , Lakhoua Youssef , Khiari Karima

A large number of endocrine pathologies can be associated to abnormalities in carbohydrate tolerance up to diabetes. The latter participates in the high risk of cardiovascular morbidity and mortality during these pathologies. The aim of our study was to assess the cardiovascular risk in a diabetic population suffering from an endocrine pathology. This is a retrospective study conducted in the department of endocrinology at Charles Nicolle Hospital involving 54 patients hospita...

ea0070aep407 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Microangiopathy and cardiovascular risk in type 2 diabetic population

Kalthoum Mehdi , Ben Nacef Ibtissem , Rojbi Imen , Adel Meriem , Mechirgui Nadia , Khiari Karima

Introduction: Type 2 diabetes is a springboard to metabolic and cardiovascular complications. The objective of our work was to investigate the different cardiovascular risk factors in diabetic type 2 population, and study relation between the level of cardiovascular risk and the occurrence of degenerative complications.Patients and Methods: Retrospective study including 149 patients with type 2 diabetes consultant at the Department of Endocrinology at th...

ea0070aep934 | Thyroid | ECE2020

Myasthenia gravis associated with Graves’ disease: About three cases

Majdoub Marwa , Rojbi Imen , Mekni Sabrine , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

Introduction: The coexistence of Grave disease [GD] and Myasthenia gravis [MG] may present a diagnostic dilemma especially concerning ocular manifestations. 3–10% of myasthenic patients exhibit GD, while MG is reported in only <1% of patients with thyroid disorder.Observation:Case 1: A 32-year-old woman, with a medical history of vitiligo, was diagnosed with GD. Immunology revealed positive anti-thyroid peroxidase antibod...