Endocrine Abstracts

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

Most of adrenal incidentalomas (AI) are nonfunctional, although some of those demonstrate an autonomous subtle cortisol hypersecretion that could lead to increased risk for osteoporosis. Several polymorphisms of glucocorticoid receptor (GR) gene have been found to alter glucocorticoid tissue sensitivity. The aim of this study was toinvestigate whether subclinical hypercortisolism (SH) and BclI variant of the GR gene have an impact on bone mineral density (BMD) in wome...

Introduction: Prolonged exposure to stress has a modifying effect on activity of hypothalamo-pituitary-adrenal (HPA) axis. This is a protective adaptation aimed to diminish potential deleterious effects of chronic hypercortisolism, and to diminish effects of acute exposure to heterotypic forms of stress. Our aim was to analyze modes of cortisol response to acute physical stress in groups of different stress categories and sex.Subjects and methods: Study ...

Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 ...

Germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with primary bilateral macronodular adrenal hyperplasia (PBMAH). PBMAH is a rare etiology of Cushing’s syndrome. This gene has been proposed to acts as a tumor-suppressor gene. A 36-years old female presented to us with clinical signs of hypercortisolism. ACTH dependent Cushing’s syndrome was confirmed soon after. Pituitary magnetic resonance imaging (MRI...

Introduction: Oligomenorrhoea have negative impact on bone mineral density (BMD). The aim of this study was to analyze BMD in oligomenorrhoeic women with polycystic ovary syndrome (PCOS), and healthy controls with regular menstrual cycles.Methods: We analyzed 29 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 23.6±4.7 years, BMI: 24.9±6.1 kg/m2) and 22 healthy BMI-matched controls (HC) (age 31.6±6.3 years, BMI 24.9&#17...