Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep618 | Endocrine-related Cancer | ECE2023

Merkel cell carcinoma, experience of a single center

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

ea0090ep582 | Endocrine-related Cancer | ECE2023

Clinical characteristics and survival of patients with functional lung neuroendocrine tumors

Popovic Bojana , Ognjanovic Sanja , Ilic Dusan , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , Micev Marijan , P. Macut Djuro

Aim: Functional neuroendocrine tumors (NETs) represent a specific diagnostic and therapeutic challenge. Hormonal clinical syndrome can severely complicate clinical picture and affect treatment. Functional pancreatic NETs have been extensively studied. Our aim was to analyze functional lung NETs in terms of clinical characteristics and survival.Materials and methods: We retrospectively analyzed data from 230 patients with lung NETs treated at our departme...

ea0063p567 | Diabetes, Obesity and Metabolism 2 | ECE2019

Cardiovascular risk in obese women with polycystic ovary syndrome using Framingham scoring system

Ilic Dusan , Bozic Antic Ivana , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Kovacevic Valentina , Ognjanovic Sanja , Macut Djuro

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

ea0070aep655 | Endocrine-related Cancer | ECE2020

Correlation of chromogranin a and standard metabolic parameters in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Bozic-Antic Ivana , Ognjanovic Sanja , Popovic Bojana , Isailovic Tatjana , Bogavac Tamara , Ilic Dusan , Elezovic-Kovacevic Valentina , Macut Djuro

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

ea0099ep419 | Adrenal and Cardiovascular Endocrinology | ECE2024

Correlation of hypothalamic-pituitary-adrenal axis parameters with the size of adrenal incidentaloma

Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Ilic Dusan , Opalic Palibrk Milica , Radic Lena , Krstic Katarina , P. Macut Djuro

Introduction: The majority of adrenocortical incidentalomas (AIs) are nonfunctional adenomas. Some of them demonstrate an autonomous cortisol secretion (ACS), a pathologic condition defined as biochemical evidence of hypercortisolism without typical signs or symptoms of CushingÂ’s syndrome.Subjects and methods: In this cross-sectional study, we evaluated 152 consecutive patients, aged 58.3 years (range, 25-84 years) of whom 105 (69.1%) with unilatera...

ea0099ep555 | Endocrine-Related Cancer | ECE2024

Genotype-phenotype correlation in serbian patients with multiple endocrine neoplasia type 2 and a mutation in codon 634 of the RET proto-oncogene

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Opalic Palibrk Milica , Radic Lena , Krstic Katarina , Macut Djuro

Introduction: Multiple endocrine neoplasia type 2 is an autosomal dominant polyglandular cancer syndrome. It arises as a result of a germline mutation of the RET proto-oncogene. The aim of this study was to evaluate the aggressiveness of medullary thyroid carcinoma (MTC) in patients with a proven germline mutation in codon 634 RET proto-oncogene, the occurrence of other associated diseases and survival analysis.Methods: The retrospectiv...

ea0090p458 | Reproductive and Developmental Endocrinology | ECE2023

Association between androgen levels and SPISE index in patients with polycystic ovarian syndrome

Radic Lena , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Bjekic Macut Jelica , Opalic Milica , Elezovic Kovacevic Valentina , Stanojlovic Olivera , Hrncic Dragan , Vojnovic Milutinovic Danijela , Macut Djuro P.

Introduction: Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, chronic oligo-/anovulation and polycystic ovarian morphology. Hyperandrogenism is a key diagnostic feature of PCOS and according to ESHRE/ASRM criteria it can be clinical and/or biochemical. SPISE index (single-point insulin sensitivity estimator index) is a new indicator of insulin sensitivity and a predictor of abnormal glucose metabolism. The aim of the research was to analyse association...

ea0063p662 | Interdisciplinary Endocrinology 1 | ECE2019

Adaptation of hypothalamo-pituitary-adrenal axis and cardio-metabolic parameters to physical stress in professional athletes

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Bozic Antic Ivana , Isailovic Tatjana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

ea0063p1130 | Reproductive Endocrinology 2 | ECE2019

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Erceg Snjezana , Lacmanovic Mirjana , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja , Vojnovic-Milutinovic Danijela , Macut Djuro

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

ea0049ep191 | Endocrine tumours and neoplasia | ECE2017

Biology and differential diagnosis of calcitonin secreting neuroendocrine tumors

Popovic Bojana , Macut Djuro , Elezovic Kovacevic Valentina , Isailovic Tatjana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Ognjanovic Sanja , Rodic Gordana , Petakov Milan , Damjanovic Svetozar

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....