Searchable abstracts of presentations at key conferences in endocrinology

ea0063p567 | Diabetes, Obesity and Metabolism 2 | ECE2019

Cardiovascular risk in obese women with polycystic ovary syndrome using Framingham scoring system

Ilic Dusan , Bozic Antic Ivana , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Kovacevic Valentina , Ognjanovic Sanja , Macut Djuro

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

ea0070aep655 | Endocrine-related Cancer | ECE2020

Correlation of chromogranin a and standard metabolic parameters in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Bozic-Antic Ivana , Ognjanovic Sanja , Popovic Bojana , Isailovic Tatjana , Bogavac Tamara , Ilic Dusan , Elezovic-Kovacevic Valentina , Macut Djuro

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

ea0063p662 | Interdisciplinary Endocrinology 1 | ECE2019

Adaptation of hypothalamo-pituitary-adrenal axis and cardio-metabolic parameters to physical stress in professional athletes

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Bozic Antic Ivana , Isailovic Tatjana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

ea0063p1130 | Reproductive Endocrinology 2 | ECE2019

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Erceg Snjezana , Lacmanovic Mirjana , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja , Vojnovic-Milutinovic Danijela , Macut Djuro

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

ea0049ep191 | Endocrine tumours and neoplasia | ECE2017

Biology and differential diagnosis of calcitonin secreting neuroendocrine tumors

Popovic Bojana , Macut Djuro , Elezovic Kovacevic Valentina , Isailovic Tatjana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Ognjanovic Sanja , Rodic Gordana , Petakov Milan , Damjanovic Svetozar

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

ea0070aep40 | Adrenal and Cardiovascular Endocrinology | ECE2020

Association of the subclinical hypercorticism and BclI glucocorticoid receptor polymorphism with bone mineral density in women with adrenal incidentalomas

Ognjanovic Sanja , Macut Djuro , Antic Jadranka , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Bozic Antic Ivana , Ilic Dusan , Elezovic Kovacevic Valentina , Damjanovic Svetozar

Most of adrenal incidentalomas (AI) are nonfunctional, although some of those demonstrate an autonomous subtle cortisol hypersecretion that could lead to increased risk for osteoporosis. Several polymorphisms of glucocorticoid receptor (GR) gene have been found to alter glucocorticoid tissue sensitivity. The aim of this study was toinvestigate whether subclinical hypercortisolism (SH) and BclI variant of the GR gene have an impact on bone mineral density (BMD) in wome...

ea0070aep87 | Adrenal and Cardiovascular Endocrinology | ECE2020

Cortisol response to acute stress is dependent on previous stress exposure and sex of the examined humans

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Isailovic Tatjana , Bozic Antic Ivana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Prolonged exposure to stress has a modifying effect on activity of hypothalamo-pituitary-adrenal (HPA) axis. This is a protective adaptation aimed to diminish potential deleterious effects of chronic hypercortisolism, and to diminish effects of acute exposure to heterotypic forms of stress. Our aim was to analyze modes of cortisol response to acute physical stress in groups of different stress categories and sex.Subjects and methods: Study ...

ea0056gp137 | Female Reproduction | ECE2018

Hypothalamo-pituitary-adrenal axis sensitivity in women with polycystic ovary syndrome

Macut Djuro , Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Bjekic-Macut Jelica , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja

Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 ...

ea0056p717 | Clinical case reports - Pituitary/Adrenal | ECE2018

Cushing’s disease, bilateral adrenal hyperplasia and ARMC5 mutation – case report

Elezovic Kovacevic Valentina , Macut Djuro , Antic Jadranka , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Bozic-Antic Ivana , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with primary bilateral macronodular adrenal hyperplasia (PBMAH). PBMAH is a rare etiology of CushingÂ’s syndrome. This gene has been proposed to acts as a tumor-suppressor gene. A 36-years old female presented to us with clinical signs of hypercortisolism. ACTH dependent CushingÂ’s syndrome was confirmed soon after. Pituitary magnetic resonance imaging (MRI...

ea0056p890 | Bone ' Osteoporosis | ECE2018

Bone mineral density in oligomenorrhoeic women with polycystic ovary syndrome

Ilic Dusan , Bozic-Antic Ivana , Bogavac Tamara , Bjekic-Macut Jelica , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja , Macut Djuro

Introduction: Oligomenorrhoea have negative impact on bone mineral density (BMD). The aim of this study was to analyze BMD in oligomenorrhoeic women with polycystic ovary syndrome (PCOS), and healthy controls with regular menstrual cycles.Methods: We analyzed 29 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 23.6±4.7 years, BMI: 24.9±6.1 kg/m2) and 22 healthy BMI-matched controls (HC) (age 31.6±6.3 years, BMI 24.9&#17...