Searchable abstracts of presentations at key conferences in endocrinology

ea0035p765 | Obesity | ECE2014

GLP-1, insulin and glucose levels during mixed test meal before and after gastric bypass surgery in obese patients

Micic Dragan , Polovina Snezana , Jeremic Danka , Micic Dusan , Sumarac-Dumanovic Mirjana

Introduction: Gastric bypass surgery in obese patients results in weight loss, changes in gastrointestinal and pancreatic hormones and improvement of insulin sensitivity.Methods: GLP-1, insulin and glucose levels were measured after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5, 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase);GLP-1 (Active 7–36) (pM/l; ...

ea0032p1003 | Thyroid (non-cancer) | ECE2013

Thyroid-stimulating hormone and insulin resistance indexes in women with polycystic ovary syndrome

Sumarac-Dumanovic Mirjana , Jeremic Danka , Stamenkovic-Pejkovic Danica , Milin Jelena , Cvijovic Goran , Micic Dragan

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...

ea0022p312 | Diabetes | ECE2010

The effects of short-term fasting on insulin sensitivity and inflammation in healthy subjects

Dumanovic Mirjana Sumarac , Micic Dragan , Pejkovic Danica Stamenkovic , Jeremic Danka , Cvijovic Goran , Stefanovic Darko , Trajkovic Vladimir

It is well known that weight losses in the range of 2.5–5% are able to improve factors of the metabolic syndrome such as insulin sensitivity. Several studies have been published concerning weight loss and subsequent changes in inflammatory markers and indicate that higher weight losses are necessary to affect the inflammatory markers than are needed to affect insulin sensitivity. Some data showed impairment of insulin sensitivity in diabetic patients during starvation. Th...

ea0022p337 | Diabetes | ECE2010

The effect of short-term metformin therapy on C-reactive protein and insulin sensitivity in newly diagnosed patients with type 2 diabetes mellitus

Micic Dragan , Dumanovic Mirjana Sumarac , Jeremic Danka , Cvijovic Goran , Polovina Snezana

C-reactive protein (CRP) is closely associated with obesity and cardiovascular disease in both diabetic and nondiabetic subjects. The aim of our study was to investigate the effects of commonly prescribed antidiabetic agent metformin on CRP and insulin sensitivity in type 2 diabetes patients after 12 weeks of therapy. Twenty-three newly diagnosed type 2 diabetic patients (mean age: 49.74±2.03 years; mean BMI: 31.40±1.27 kg/m2) have been given metformin 2 g...

ea0022p353 | Diabetes | ECE2010

Insulin sensitivity and acute insulin response in pateints with primary hyperparathyroidism before and after surgical treatment

Cvijovic Goran , Micic Dragan , Kendereski Aleksandra , Zoric Svetlana , Sumarac-Dumanovic Mirjana , Stamenkovic-Pejkovic Danica , Jeremic Danka

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and acute insulin response (AIR) in patients with PHPT.Methods: In patients with PHPT (n=37; age: 57.72±8.29 years, BMI 26.22±4.37 kg/m2) euglycemic–hyp...

ea0020p476 | Obesity and Metabolism | ECE2009

Relationship of serum gamma-glutamyltransferase and adiposity measures with C-reactive protein in severe obese women

Sumarac-Dumanovic Mirjana , Micic Dragan , Stamenkovic-Pejkovic Danica , Cvijovic Goran , Jeremic Danka , Kendereski Aleksandra

Introduction and aims: Recent epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Obesity is associated with elevated levels of biomarkers of inflammation and endothelial dysfunction. Oxidative stress and inflammation are also known to play critical roles in the pathogenesis of vasc...

ea0049ep694 | Obesity | ECE2017

Association between obesity and glomerular hyperfiltration: impact on metabolic risk factors

Sumarac-Dumanovic Mirjana , Gligic-Kuzmanovic Ana , Stamenkovic-Pejkovic Danica , Polovina Snezana , Jeremic Danka , Cvijovic Goran , Zoric Svetlana , Micic Dragan

Abstract: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease, independently of classical risk factors such as diabetes. In terms of determining the creatinine clearance has numerous drawbacks, in clinical use are predictors of glomerular filtration rate (GFR) which show varying degrees of accuracy in obese patients. The aim of our study was to determine whether it is in our group of obese patients without type 2 dia...

ea0041ep630 | Endocrine tumours and neoplasia | ECE2016

A thymic carcinoid tumor causing Cushing syndrome in the setting of a multiple endocrine neoplasia syndrome type 1

Gligic Ana , Sumarac-Dumanovic Mirjana , Kendereski Aleksandra , Stamenkovic-Pejkovic Danica , Cvijovic Goran , Zoric Svetlana , Jeremic Danka , Micic Dragan

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN1) associated thymic carcinoids (Th-NETs) are rare and have poor prognosis. Cushing syndrome (CS) caused by Th-NET in MEN1 syndrome is extremely rare.Case report: We report a case of a 55-year-old man with CS at presentation due to ectopic ACTH production in MEN1 syndrome. Thirty years ago, this patient had total gastric resection due to Zollinger-Ellison’s syndrome and extirpation of tw...

ea0037ep180 | Reproduction, endocrine disruptors and signalling | ECE2015

Post load insulin vs fasting levels in prediction of type 2 diabetes in women with PCOS

Sumarac-Dumanovic Mirjana , Micic Dragan , Stamenkovic-Pejkovic Danica , Gligic Ana , Jeremic Danka , Milin-Lazovic Jelena , Cvijovic Goran

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...

ea0032p784 | Obesity | ECE2013

PTH one year after gastric bypass in morbidly obese patients

Polovina Snezana , Micic Dragan , Gligorijevic Jelena , Sumarac-Dumanovic Mirjana , Cvijovic Goran , Stamenkovic-Pejkovic Danica , Milin Jelena , Micic Dusan , Jeremic Danka

Introduction: After gastric bypass, gastric secretion decreased and resorption of minerals and vitamins may be compromised. Lower resorpion of serum calcium and vitamin D could stimulate PTH secretion after restictive and malabsorptive bariatric procedures.Methods: We have measured serum calcium, D vitamin and PTH in patients (n=50, 17 males and 33 females) 6 and 12 months after R en Y gastric bypass, 38.6±12.6 years of age, with BMI 43&#17...