Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep343 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Irisin plasma level is connected with the android adipose tissue deposit

Pukajlo Katarzyna , Kolackov Katarzyna , Laczmanski Lukasz , Kuliczkowska-Plaksej Justyna , Bolanowski Marek , Milewicz Andrzej , Daroszewski Jacek

Irisin (Ir), a recently identified adipomyokine, cleaved and secreted to the circulation from the FNDC5 protein in response to physical activity and some environmental conditions has been postulated to induces the differentiation of a subset of white adipocytes into brown fat and mediates the beneficial effects of exercise on metabolic homeostasis. Polycystic ovary syndrome (PCOS) – one of the most frequent endocrinopathies affecting women of child-bearing age is associat...

ea0035p758 | Obesity | ECE2014

Irisin plasma concentration in PCOS and healthy subjects is related to body adipose content

Pukajlo Katarzyna , Kolackov Katarzyna , Laczmanski Lukasz , Kuliczkowska-Plaksej Justyna , Lenarcik-Kabza Agnieszka , Milewicz Andrzej , Daroszewski Jacek

Polycystic ovary syndrome (PCOS) is a common endocrine abnormality connected not only with reproductive problems but also with impaired energy homeostasis leading to metabolic disorders including metabolic syndrome. Irisin (Ir), recently identified novel myokine, has been proposed to mediate some of the positive influence on metabolic disorders. The aim of our study was to search the relationship between Ir plasma concentration in PCOS in the context of metabolic disturbances....

ea0035oc8.2 | Pituitary clinical | ECE2014

Soluble α-Klotho – a new serum biomarker for the activity of acromegaly

Jawiarczyk-Przybylowska Aleksandra , Bolanowski Marek , Kolackov Katarzyna

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

ea0035p152 | Calcium and Vitamin D metabolism | ECE2014

The effect of VDR polymorphisms on serum testosterone level in aging men population

Laczmanski Lukasz , Lwow Felicja , Kolackov Katarzyna , Milewicz Andrzej

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...

ea0049gp165 | Obesity | ECE2017

The effect of FTO polymorphism rs 9939609 on obesity and metabolic disturbances in Polish people from Lower Silesia

Zdrojowy-Welna Aleksandra , Kolackov Katarzyna , Zatonska Katarzyna , Tupikowska-Marzec Malgorzata , Bolanowski Marek , Bednarek-Tupikowska Grazyna

Background: The association between fat mass and obesity-associated gene (FTO) polymorphism rs 9939609 and obesity was found in some European countries. However, the data concerning Polish population is insufficient. The relationship between FTO and metabolic disorders remains unclear.Methods: The study group consisted of 686 women and 418 men from Lower Silesia in Poland, aged 30–80 years (mean age 54.2±9.26 years). The examination included an...

ea0035p759 | Obesity | ECE2014

May the FTO gene affect visceral obesity? Study of variant rs9930506 SNP among the MONW in a Polish population

Kolackov Katarzyna , Laczmanski Lukasz , Tupikowska Malgorzata , Zdrojowy-Welna Aleksandra , Bednarek-Tupikowska Grazyna

Objective: Genetic factors play a major role in obesity. Numerous studies have confirmed associations of the SNP rs9930506 of FTO gene with increased BMI, hip circumference and total body weight. The metabolic consequences of obesity depend, to a large degree, on body fat distribution.MONW individuals (metabolically obese normal-weight), despite their normal BMI, are characterized by visceral obesity and display metabolic properties that may pre...

ea0070aep692 | Pituitary and Neuroendocrinology | ECE2020

Quantitative bone assessment by radiofrequency echographic multi-spectrometry (REMS) in patients with acromegaly – a preliminary study

Halupczok-Żyła Jowita , Rolla Małgorzata , Jawiarczyk-Przybyłowska Aleksandra , Kolackov Katarzyna , Bolanowski Marek

Introduction: Acromegaly is a rare diseaseresulting most commonly from pituitary adenoma. A chronic increase of growth hormone (GH) and insulin-like factor 1 (IGF-1) leads to many systemic complications including osteoporosis and fractures. Radiofrequency echographic multi-spectrometry (REMS) is a new non-ionizing technique to diagnose osteoporosis.Purpose: The objective of the study was to evaluate bone mineral density (BMD) by REMS in patient...

ea0037oc11.2 | Obesity | ECE2015

Serum glypican-4 levels and its association with cardiovascular risk predictor in women with polycystic ovary syndrome and healthy controls -- pilot study

Milewicz Andrzej , Kuliczkowska-Plaksej Justyna , Lenarcik-Kabza Agnieszka , Trzmiel-Bira Anna , Hirnle Lidia , Zaleska-Dorobisz Urszula , Lwow Felicja , Laczmanski Lukasz , Kolackov Katarzyna , Sloka Natalia , Jedrzejuk Diana

Glypican-4 (Gpc-4) is novel adipokine interact with insulin receptor and affects insulin sensitivity in proteoglycans. Gpc-4 serum levels show gender differences; females having higher levels than men, what can suggest mediation by sex hormones. We investigated serum Gpc-4 levels and its association with cardiovascular risk predictors in women (20–35 years old) with PCOS (n=62) and healthy control (n=43) presented different sex hormones profile. The foll...

ea0070aep527 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hormonal function of muscles in acromegaly in relation to metabolic disorders

Mizera Łukasz , Grzegrzółka Jędrzej , Halupczok-Żyła Jowita , Jędrzejuk Diana , Kolackov Katarzyna , Bolanowski Marek , Daroszewski Jacek

Skeletal muscle constitutes the largest endocrine organ in human body through capability of secreting myokines, which biological activity plays a key role in energy homeostasis. Among the myokines irisin (Ir) is of particular interest, considering it’s broad spectrum of protective influence on obesity and metabolic diseases development, determining therapeutical potential of this molecule. Latest studies indicate close interrelations between Ir and myostatin (Mstn), myok...

ea0032p204 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

CNR1 polymorphisms and metabolic disorders in woman with PCOS-preliminary report

Milewicz Andrzej , Laczmanski Lukasz , Lenarcik Agnieszka , Kuliczkowska Justyna , Trzmiel-Bira Anna , Stachowska Barbara , Jedrzejuk Diana , Sadowska Ewa , Kolackov Katarzyna , Pawlak Maurycy , Arkowska Anna , Dorobisz Urszula , Hirmle Lidia , Lwow Felicja

The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. Insulin resistance play important role in etiology in PCOS. The aim of our study was developed the role of CNR1 polymorphisms (rs806368, rs12720071, rs1049353, 806381, rs10485170, rs6454674, rs2023239) in metabolic disorders in woman with PCOS. 88 woman (20–35 years old) with PCOS (recognized using Rotterdam criteria) and 77 woman (20–3...