Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.10.02 | Calcium, Vitamin D and Bone | ECE2015

Comparison of two methods in assessment of fracture risk of postmenopausal women with osteopenia

Kuzma Martin , Nemethova Eva , Killinger Zdenko , Payer Juraj

Introduction: More than half of osteopenic patients suffer from fracture (Fx), but BMD osteopenia is usually not considered for treatment initiation. FRAX, tool that can identify patients with high Fx risk based on major risk factors, can be used as an interventional threshold. Past few years, trabecular bone score (TBS), the bone quality determinant, is a promising method identifying the high-risk patients according to degradation of trabecular bone.Obj...

ea0035p677 | Growth hormone IGF axis basic | ECE2014

Positive impact of GH treatment on trabecular bone using grey-level texture analysis

Kuzma Martin , Kuzmova Zuzana , Vanuga Peter , Killinger Zdenko , Payer Juraj

Introduction: GH deficiency (GHD) is associated with reduced bone mineral density (BMD) and treatment leads to its increase. BMD, a quantitative bone parameter, doesn’t bring whole information about bone status. Nowadays, bone quality shows as main determinant of bone strength, fracture prediction and treatment effect monitoring. A method to assess bone quality through the grey-level texture analysis from lumbar spine DXA scan is trabecular bone score (TBS).<p class="...

ea0041gp37 | Bone &amp; Calcium Homeostasis | ECE2016

Trabecular bone score in patients with inflammatory bowel diseases

Krajcovicova Anna , Kuzma Martin , Kaniaris Aristodimos Grigorios , Killinger Zdenko , Hlavaty Tibor , Payer Juraj

Introduction: Osteoporosis is known chronic complication of inflammatory bowel diseases (IBD). It is known that areal bone mineral density (aBMD) does not sufficiently reflect bone strength and quality. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of aBMD.Aims and methods: The aim was to assess TBS in IBD patients with regard to disease behavior using in comparison with lumbar spine (LS) BMD. The...

ea0022p98 | Bone/Calcium | ECE2010

Teriparatide in the treatment of severe osteoporosis: results of a multicenter prospective study

Payer Juraj , Tomkova Sona , Killinger Zdenko , Jackuliak Peter , Vanuga Peter , Letkovska Alexandra , Masaryk Pavol , Kmecova Zlata

Introduction: Teriparatide (TPTD) is a recombinant aminoterminal fragment (1–34) of the human parathyroid hormone (PTH), which has a predominantly stimulating effect on bone formation. We report results of an 18-month prospective multicenter study with daily s.c. application of 20 μg of teriparatide in 85 elderly women with severe osteoporosis, the efficacy, safety and compliance of the treatment.Outcomes: The primary outcomes were defined as c...

ea0020p246 | Bone/Calcium | ECE2009

The relationship between serum TSH, free T4 and bone mineral density in pre- and postmenopausal women

Baqi Lahim , Langer Pavel , Killinger Zdenko , Homerova Zuzana , Kollerova Jana , Banarova Adriana , Payer Juraj

Background: Thyroid-stimulating hormone (TSH) might influence bone mineral density (BMD) through its regulation of the thyroid hormones thyroxine (T4) and triiodthyronine (T3). Direct effect of TSH on bone turnover, mediated through its receptors on both osteoblast and osteoclast precursors, has been suggested. We wanted to explore the relationship between serum TSH, fT4 and BMD in women with different TSH levels after a long-term observation of thyroid function and bone statu...

ea0070aep170 | Bone and Calcium | ECE2020

Long term effect on trabecular bone score but not BMD is preserved in GH-deficient adults only when sufficient vitamin D levels are maintained

Kužma Martin , Smaha Juraj , Stojkovičová Daša , Jackuliak Peter , Killinger Zdenko , Payer Juraj

Introduction: Adult growth hormone deficiency (AGHD) is associated with lower bone mass and likely with increased risk of fragility fractures. GH replacement leads to increase in bone mineral density (BMD) and trabecular bone score (TBS). The effect of adequate levels of vitamin D during GH replacement is important to provide effect on TBS.Aim: To assess long–term effectof recombinant GH replacement on BMD and TBS with regards to vitamin D levels d...

ea0056p175 | Bone ' Osteoporosis | ECE2018

Acromegaly patients with vertebral fractures, have lower trabecular bone score despite no difference in bone mineral density, than non-fractured patients and healthy controls

Kuzma Martin , Vanuga Peter , Sagova Ivana , Pavai Dusan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Genant Harry , Payer Juraj

Introduction: Patients with acromegaly, despite normal or even high bone mineral density (BMD), have prevalent vertebral fractures (VFs). HR-pQCT studies in acromegaly have proposed that impaired trabecular bone microarchitecture possibly plays a role in fragility fracture development. As such, we hypothesized that trabecular bone score (TBS) would be low in patients with acromegaly.Aim of the study: To compare BMD and TBS in acromegaly patients with and...

ea0063p93 | Calcium and Bone 1 | ECE2019

Analysis of non-invasive DXA-derived bone structure parameters in patients with acromegaly with regards to vitamin D levels

Kužma Martin , Vaňuga Peter , Sagova Ivana , Pavai Dušan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Winzenrieth Renaud , Genant Harry , Payer Juraj

Introduction: Patients suffering from acromegaly, despite normal or even higher bone mineral density (BMD), have prevalent vertebral fractures (VFs). Impaired bone microarchitecture is involved fragility fracture development, but vitamin D status could be involved in this impairment.Aim of the study: Comparison of bone parameters such as BMD, trabecular bone score (TBS) and 3D-SHAPER parameters in acromegaly patients according to level of 25(OH)D3.<p...

ea0049gp38 | Bone & Calcium Homeostasis 1 | ECE2017

Decreased trabecular bone score but not bone mineral density in patients with acromegaly and concurrent hypogonadism: cross-sectional study with healthy controls

Kužma Martin , Pavai Dušan , Sagova Ivana , Killinger Zdenko , Jackuliak Peter , Vaňuga Anton , Vaňuga Peter , Payer Juraj

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.</p...

ea0081p332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

COVID-19 pneumonia patients with 25(OH)D levels lower than 12 ng/ml are at increased risk of death

Smaha Juraj , Kužma Martin , Brazdilova Kristina , Nachtmann Samuel , Jankovsky Martin , Pastirova Katarina , Gažova Andrea , Jackuliak Peter , Killinger Zdenko , Kyseloviž Jan , Koller Tomaš , Binkley Neil , Payer Juraj

Objectives: There is no consensus about specific serum 25(OH)D levels associated with higher risk of severe outcome in COVID-19 patients. According to the literature patients with serum 25(OH)D levels < 12 ng/ml are clearly deficient at all ages. Our aim was to assess COVID-19 mortality in the settings of severe 25(OH)D deficiency.Methods: A cohort study of 357 COVID-19 patients was conducted. Subjects were monitored until discharge or in-hospital de...