Endocrine Abstracts

Introduction and objective: The research was conducted with the aim of highlighting the awareness and understanding of the disease among diabetic patients.Methods: The study included 85 patients with type 2 diabetes, aged 40+ years old, who had been monitoring their blood glucose levels and HbA1c levels in the previous 4 months. Patients were presented a questionnaire with 5 questions about diabetes. The patients’ responses were classified and expre...

Introduction: Diabetes mellitus (DM) is a chronic disease that can be largely managed in the primary care system.Aim: We analysed medical records of diabetic patients (pts) treated in Center for diabetes in our institution, during 1 year, determining the quality of care.Material and methods: The search was focused on pts at first admission to the diabetologist. Analysis included demographic and clinical characteristics of pts, meta...

Background: GLP-1 agonism have the potential to affect gastric emptying (GE), yet the reports for subcutaneous semaglutide, currently the most effective GLP-1 RA approved for weight management, remain inconclusive. It has been demonstrated that semaglutide either had no effect on GE or it delayed GE only within the first hour, without late phase retention. Notably, those conclusions were made by an indirect method of estimation of GE through ingestion, absorption and determina...

Introduction: Antiresorptive treatment can preserve bone mineral density (BMD) in patients with primary hyperparathyroidism (PHPT) when surgery is not feasible or desired. We aimed to compare the impact of zoledronate vs denosumab on bone-related biochemical parameters in this population.Methods: We analyzed preliminary data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated either with zoledronate 5 mg...

Functional interplay between different classes of receptors has emerged as a notable factor of cellular response in health and disease. One of the most prominent examples of cross-talk involves the regulation of glucose metabolism, a major regulatory function under the influence of both insulin receptor (IR) and β2-adrenergic receptor (β2-AR) representing the receptor tyrosine kinases (RTKs) and the seven transmembrane receptors (7TMRs) respecti...

Introduction: Early hyperglycemia in acute pancreatitis (AP) is prognostic sign of severe attack. Elevated lipid levels are one of the major risk factors for AP. The objective of this work was to evaluate the glycaemic and lipid profile in patients (pts) with acute pancreatitis, treated in our institution.Methods: A total of sixty nine pts with AP were admitted to a Department of Internal medicine, from January to December 2012.At ...

Background: Cranial Diabetes Insipidus (CDI) or Arginine-Vasopressin Deficiency (AVP-D) is a potentially life-threatening condition requiring treatment with desmopressin. Omission or delay in desmopressin can result in serious patient harm.Aims: Evaluation of desmopressin prescription/administration practice and implementation of an action plan to improve patient safety.Methods: Re...

Introduction: To understand the pathological changes associated with glucose homeostasis in old age, it is necessary to know the natural changes in the processing of proinsulin into mature insulin. Surprisingly, while there is abundant information about insulin function in diabetics, the situation in healthy adults and old humans was rarely examined.The study aimed: To determine how the proinsulin secretion in individuals with normal glucose tolerance ch...

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

Background: Laparoscopic adrenalectomy (LA) is the standard treatment for benign adrenal tumours but its role in the surgical management of adrenocortical carcinoma (ACC) is controversial. Therefore, the aim of this study was to compare long-term outcome between open adrenalectomy (OA) and LA in the treatment of primary ACC.Methods: This retrospective cohort study included patients with ACC ENSAT stage I-III referred to the Croatian referral centre for a...