Endocrine Abstracts

34 years old male patient was admitted to Endocrine department with palpitation (130–140 beats/minute), weight loss(15 kg during 3 months), anxiety, nervousness, hand tremor, generalized nocturnal pruritus. Laboratory examination showed: decreased level of thyroid stimulating hormone (TSH) <0.005 (n 0.3–4.0 iu/ml), markedly increased level of free thyroxin (FT4) - 100(n 12–22 pmol/l), free triiodthryonine FT3-6,5 (n-0,8-2,0 ng/ml),anti-R-TSH 15-(n- <1,75...

Background: Wolfram syndrome is an autosomal recessive neurodegenerative disorder characterised by Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness (also referred to as DIDMOAD). An estimated prevalence is 1 in 770,000 and an estimated carrier frequency is 1 in 354. Herein, we describe the course of wolfram syndrome in two female siblings.Case presentations: The first patient is a 30-year ...

Introduction: The thyroid gland is affected by amyloidosis in 50% of cases in primary amyloidosis and80% in secondary amyloidosis.Case report: The patient, male, born in 1976 was admitted to the department of endocin Surguary of the Astghik Medical Center, Armenia complaining of general weakness, feeling of compression and heaviness in the neck (cervical discomfort), cough, shortness of breath, swallowing difficulty. When the patient was 12 years old dia...

Background: Graves’ orbitopathy (GO), also known as thyroid eye disease, is an autoimmune condition and is one of the main extrathyroidal manifestations of Graves’ disease. GO is relatively rare and usually accompanies the onset or develops soon after the Graves’ disease. We present a case of GO that developed 18 years later from total thyroidectomy. Case report: A 64-year-old men presented at the ophthalmology clinic with one-month histor...

Background: Graves’ orbitopathy (GO) is one of the extrathyroidal manifestations of Graves’ disease (GD), an autoimmune condition characterised by increased antibodies against TSH receptors (TRAb). The prevalence of GO among patients with GD is up to 40%. Moderate-to-severe, sight-threatening and sometimes even mild GO have significant negative impact on patient’s quality of life (QoL). Various clinical presentations of GD itself, evaluation and timely managemen...

Background: September is celebrated as PCOS awareness month worldwide and is aimed at improving the lives of those with PCOS, promoting research, and strengthening advocacy efforts. While significant financial and human resources are invested in promotions during this month, to the best of our knowledge, there is no evidence to show the impact of this initiative. In our study, we evaluated the global digital impact of PCOS Awareness Month, tracking commonly used hashtags as su...

Introduction: Older age and diabetes are both risk factors for frailty. Functional decline and disability in older, frail adults with diabetes results in an increased susceptibility to falls and hospital admission. Hypoglycaemia is common and more likely to result in hospital admission in older adults with diabetes and frailty. An HbA1c of below 7% (53 mmol/mol) is likely to represent overtreatment of hyperglycaemia. JBDS has recommended a review of HbA1c...

Thyroid hormones (THs) play a critical role in the regulation of growth and development in both animals and humans. They regulate metabolism primarily through actions in the brain, white fat, brown fat, skeletal muscle, liver and pancreas. Therefore, it is not surprising that since a long time scientists have been interested in measuring TH concentration in different tissues and to relate this value with possible dysfunctions. In general, TH levels are measured by immunoassay ...

IntroductionRecently, apart from its main physiologic role, the active form of vitamin D has also been recognised to have anti-inflammatory and immune-modulating properties. Accumulating evidence suggests that Vitamin D deficiency is associated with increased prevalence of various autoimmune diseases, and in particular, with autoimmune thyroid disease. Despite contradicting evidence, the balance is tipping towards inverse correlation between vitamin D de...

Background: Hypophysitis is a rare inflammatory condition of the pituitary gland, speculated to have autoimmune aetiology. The diverse clinical presentations rely on hormonal deficiencies and the pathophysiological impact on the target organs. This condition may give rise to life-threatening complications. MRI is the best imaging modality for diagnosis and the conclusive diagnosis necessitates a biopsy of the affected tissue. The optimal management approach remains a subject o...