Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep793 | Pituitary and Neuroendocrinology | ECE2022

Importance of neurosurgical expertise and multidisciplinary approach in pituitary patients

Pederzoli Simone , Monzani Maria Laura , Vincentis Sara De , Madeo Bruno , Diazzi Chiara , Rochira Vincenzo

Background: Multidisciplinary approach to pituitary disease is highly recommended; it requires a close relationship between expert pituitary surgeons and endocrinologists together with several specialists (e.g. neuroradiologists) in order to provide a high-level standard of care. Although there is evidence that neurosurgeons’ expertise is a key element to achieve better outcomes, also endocrinologists’ role is fundamental but it may sometimes encounter real-life barr...

ea0063p255 | Pituitary and Neuroendocrinology 1 | ECE2019

Trunk fat increase is prevented both in patients undergoing long-lasting continuous r-hGH therapy and in those who discontinued r-hGH compared to untreated patients: results from baseline data of the MAGHD study

Monzani Maria Laura , Magnani Elisa , Diazzi Chiara , Pederzoli Simone , Volpi Laura , Rochira Vincenzo

Background: Adult growth hormone (GH) deficiency (AGHD) is related with alterations in body composition, increased abdominal and visceral adiposity, adverse change in lipid and carbohydrate metabolism, and reduction of bone mineral density (BMD).Aim: To compare baseline outcomes concerning body composition and biochemical/hormonal data among adult patients with AGHD referring to a single endocrinological center and grouped according to their history of r...

ea0056p215 | Calcium & Vitamin D metabolism | ECE2018

Reliabilty of serum Calcium to Phosphorus (Ca/P) ratio as an accurate and inexpensive toolto define disorders of Ca-P metabolism: preliminary data

De Vincentis Sara , Monzani Maria Laura , Kara Elda , Guaraldi Giovanni , Rochira Vincenzo , Madeo Bruno

Background: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (>3.5 if Ca and P are expressed in mg/dl) from healthy subjects [1]. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP), might impair the Ca/P ratio.Aim: To ...

ea0081p167 | Pituitary and Neuroendocrinology | ECE2022

Patient-reported outcomes (PRO) in adult growth hormone deficiency (aghd) for an improved patients’ management: results from the management of AGHD(MAGHD) study

Monzani Maria Laura , Pederzoli Simone , Bellelli Alessio , Magnani Elisa , Diazzi Chiara , Golinelli Caterina , Pacchioni Marco , Orsini Mirko , Rochira Vincenzo

Background: AGHD is a recognized clinical entity, but symptoms are quite nonspecific; the lack of objective tools able to measure patients’ health status remains the main barrier in clinical monitoring and treatment.Aim: The MAGHD Study aims improving AGHD patients’ management through a Smartphone app (MAGHDApp) and a fit-watch integrated with a software framework able to merge daily data of patients’ well-being and physical activity with ...

ea0063gp262 | Thyroid Nodules and Cancer 2 | ECE2019

Classification of thyroid nodules by ultrasound in clinical practice: the added value of the judgment of the skilled endocrinologist

Madeo Bruno , Brigante Giulia , Ansaloni Anna , Taliani Erica , Kaleci Shaniko , Monzani Maria Laura , Simoni Manuela , Rochira Vincenzo

Background and aim: Several ultrasound (US) classifications for thyroid nodules have been proposed. Since most of them are hardly applicable in clinical practice, we set up the Modena US Thyroid Classification (MUT) that stratifies the risk of malignancy considering both knowledge derived from scientific literature and clinician subjective impression. The aim of the present study was to test the diagnostic accuracy of different thyroid US classification systems, AACE/ACE-AME, ...

ea0056p1051 | Thyroid (non-cancer) | ECE2018

Thyroid ultrasound alterations occurrence in patients with previous negative examination: A 6-years observational follow-up trial

Monzani Maria Laura , Brigante Giulia , Locaso Michela , Santi Daniele , Graziadei Luigi , Gnarini Valentina Luisa , Simoni Manuela , Madeo Bruno

Background: Thyroid nodules represent a common clinical finding and their prevalence is increasing worldwide. However, the most recent international guidelines do not give indications on the need to retest adults with previous negative neck ultrasound (US).Aim: To evaluate the incidence of thyroid US abnormalities in patients with previous negative thyroid US and identify patient’s characteristics able to predict the risk of developing thyroid disea...

ea0081oc11.1 | Oral Communications 11: Thyroid 2 | ECE2022

Thr92Ala polymorphism of the type 2 deiodinase (DIO2) is associated with higher risk of iatrogenic thyrotoxicosis in thyroidectomized subjects treated with levothyroxine and liothyronine

Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Simoni Manuela , Rochira Vincenzo , Santi Daniele , Brigante Giulia

Introduction: Hypothyroidism treatment is classically based on levothyroxine (LT4). However, 10% of hypothyroid patients treated with LT4 complain of hypothyroidism symptoms, despite normal thyroid stimulating hormone (TSH) serum levels. This ”peripheral hypothyroidism” has been linked to decreased availability of free triiodothyronine (fT3), likely related to single nucleotide polymorphisms (SNP) in deiodinase genes (DIO), reducing enzymatic activity. Since...

ea0067o14 | Oral Presentations | EYES2019

Effects of thyroid function on peripheral serum markers: results from a cohort of thyroid cancer patients

Monzani Maria Laura , De Vincentis Sara , Della Casa Venturelli Francesca , Piccinini Francesca , Tagliavini Simonetta , Peeters Robin P , Simoni Manuela , Brigante Giulia

Objective: The aim of this study was to identify changes in thyroid hormone metabolism occurring in different thyroid functional states and to evaluate tissue response to thyroid hormone changes.Methods: Two hundred subjects (137 F, 63 M, mean age: 50.3±14.4 years) waiting to be treated or treated with total thyroidectomy for differentiated thyroid cancer were enrolled in this study. Thyroid function was investigated measuring TSH, fT4 and fT3, and ...

ea0035p519 | Endocrine tumours and neoplasia | ECE2014

BRAF V600E mutation in washing liquid of thyroid fine-needle aspiration: a surprising tool in cytological benign nodules

Monzani Maria Laura , Brigante Giulia , Marino Marco , Bonacini Lara , Pignatti Elisa , Cioni Katia , Madeo Bruno , Rochira Vincenzo , Santi Daniele , Maiorana Antonino , Carani Cesare , Simoni Manuela

Objective: Thyroid fine-needle aspiration (FNA) cytology is indeterminate in 15–25% of cases. Recently, cytological analysis was combined to molecular analysis to improve diagnostic accuracy. In the present study, washing liquid of FNA (wFNA) samples were tested for the BRAF V600E mutation, using high resolution melting (HRM) technology. The aim of this study was to demonstrate whether BRAF mutation analysis is accurate in wFNA and, when combined with cytological analysis...

ea0090oc2.1 | Oral Communications 2: Thyroid | ECE2023

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

Brigante Giulia , Santi Daniele , Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Roy Neena , Casarini Livio , Trenti Tommaso , Varani Manuela , De Santis Maria Cristina , Roli Laura , Rochira Vincenzo , Simoni Manuela

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...