Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp55 | Cardiovascular & Lipid Endocrinology | ECE2017

Both oral and vaginal combined hormonal contraceptives induce unbeneficial metabolic effects in women with PCOS: a randomized study

Mosorin Maria-Elina , Piltonen Terhi , Tapanainen Juha , Morin-Papunen Laure

Oral combined hormonal contraceptives (CHCs) have been suggested to induce more unbeneficial metabolic effects than vaginal CHCs. CHCs are used routinely to treat the clinical symptoms of polycystic ovary syndrome (PCOS), but there are no studies investigating whether the vaginal route is safer in women with known metabolic risks.Twenty-five women with PCOS defined according to the Rotterdam criteria were randomized to use either oral contraceptive pills...

ea0063p332 | Reproductive Endocrinology 1 | ECE2019

Natural estradiol in combined oral contraceptive has a favorable inflammation and lipid profile compared with preparation containing ethinyl estradiol– a randomized controlled trial

Kangasniemi Marika , Haverinen Annina , Heikinheimo Oskari , Luiro Kaisu , Arffman Riikka , Tapanainen Juha , Piltonen Terhi

Study question: Does the combination of estradiol valerate (EV) and dienogest (DNG) have favorable effects on inflammation and lipids compared with ethinyl estradiol (EE) + DNG?What is known already: Use of combined oral contraceptives (COCs) increases HDL-cholesterol and triglycerides and promotes low-grade inflammation. The metabolic effects of COCs depend on both estrogen and progestin components. To our knowledge this is the first study comparing COC...

ea0081rc12.5 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Association of Early Adulthood Hyperandrogenemia With Hypertension and Cardiovascular Events in Women

Tuorila Katri , Ollila Meri-Maija , Jarvelin Marjo-Riitta , Tapanainen Juha , Franks Stephen , Piltonen Terhi , Kaikkonen Kari , Morin-Papunen Laure

Background: Cardiovascular diseases (CVD) present sex specific characteristics, suggesting sex-hormones playing a role in the pathophysiology of CVDs. Hyperandrogenemia (HA) is a common condition in fertile age women but whether HA is a risk factor for CVD is still controversial.Aims: To clarify the association of HA with the development of hypertension and CVDs in women.Study population and methods: A general population-based birt...

ea0081rc12.8 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Ethinyl estradiol in a combined contraceptive exerts greater effect on serum proteome than estradiol valerate – a randomized trial

Kangasniemi Marika , Arffman Riikka , Joenvaara Sakari , Haverinen Annina , Luiro Kaisu , Tohmola Tiialotta , Renkonen Risto , Heikinheimo Oskari , Tapanainen Juha , Piltonen Terhi

Background: Combined oral contraceptives (COC) are known to have multiple beneficial effects besides contraception, but also cause some unwanted health outcomes. They interfere, for example, with metabolism, inflammation, hepatic protein synthesis and blood coagulation. COCs containing natural estrogens have recently been developed, yet little is known about their non-contraceptive effects compared to conventional COCs with ethinyl estradiol (EE). The aim of this study was to ...

ea0056p939 | Female Reproduction | ECE2018

Polycystic ovary syndrome (PCOS) associates with dissatisfied body image and weight loss attempts at age 31 and 46 – A prospective, population-based Cohort study

Sundelin Fia , Koivuaho Emilia , Jarvelin Marjo-Riitta , Laitinen Jaana , Tapanainen Juha S , Franks Stephen , Morin-Papunen Laure , Piltonen Terhi T

Introduction: Being overweight or obese are common characteristic of women affected by polycystic ovary syndrome (PCOS). Indeed, 50–70% of the women are obese and more likely to present with higher growth rate and obesity already from early childhood compared with women without the syndrome. Obesity predisposes women with PCOS to adverse metabolic outcomes such as metabolic syndrome, insulin resistance and diabetes. Recent studies have also revealed a high prevalence of e...

ea0073pep4.1 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Effect of oral contraceptives containing estradiol valerate vs. ethinyl estradiol combined with dienogest on biomarkers of coagulation – a randomized clinical trial

Haverinen Annina , Luiro Kaisu , Szanto Timea , Kangasniemi Marika , Hiltunen Leena , Sainio Susanna , Piltonen Terhi , Lassila Riitta , Tapanainen Juha , Heikinheimo Oskari

ObjectiveTo compare the effects of combined oral contraceptives (COCs) containing estradiol valerate (EV) and dienogest (DNG) with ethinyl estradiol (EE) and DNG on biomarkers of coagulation: thrombin generation (TG), prothrombin fragments F1+2 (F1+2) and D-dimer (D-Di). A DNG-only preparation was included as a control.BackgroundCOC use increases the risk of venous thromboembolism (VTE) 2-6-fold compa...

ea0081oc5.3 | Oral Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Weight loss attempts and weight perception in women with polycystic ovary syndrome (PCOS) - a 15-year follow-up in a population-based cohort study

Pesonen Emilia , Ollila Meri-Maija , Morin-Papunen Laure , Tapanainen Juha S , Jamsa Timo , Korpelainen Raija , Niemela Maisa , Nurkkala Marjukka , Piltonen Terhi T

Background: Women with polycystic ovary syndrome (PCOS) experience increased weight gain during life, thus weight management and preventing weight gain should be the first line treatment. Weight loss is usually self-initiated because practical support for weight management is often limited or even lacking. Perception of overweight is considered an important prerequisite for weight loss attempts, although there is no prior research regarding women with PCOS. The main aim of the...

ea0049ep1110 | Female Reproduction | ECE2017

Hyperandrogenism and overweight/obesity, independently and interactively, increase the risk of metabolic syndrome and type 2 diabetes in women – a Prospective, Population-based Cohort Study

Ollila Meri-Maija , Kaikkonen Kari , Keinanen-Kiukaanniemi Sirkka , Puukka Katri , Ruokonen Aimo , Jarvelin Marjo-Riitta , Tapanainen Juha , Franks Steve , Piltonen Terhi , Morin-Papunen Laure

The significance of hyperandrogenism (HA) as a metabolic risk factor in women is controversial. HA can be defined as either clinical (hirsutism) or biochemical (elevated androgen levels). We aimed to investigate whether HA at age 31 associates with metabolic syndrome (MetS), type 2 diabetes mellitus (DM2) or carotid intima media thickness (CIMT) by age 46. In a prospective, general population-based follow-up birth cohort (n=5889 women) blood samples were collected at ...

ea0070aep784 | Reproductive and Developmental Endocrinology | ECE2020

Polycystic ovary syndrome is burdened with a high comorbidity rate and medication use independent of BMI: A longitudinal community based study

Kujanpää Linda , Piltonen Terhi , Arffman Riikka , Pesonen Paula , Morin-Papunen Laure , Tapanainen Juha , Franks Stephen , Järvelin Marjo-Riitta

Objective: To investigate comorbidity rate, symptoms, overall morbidity, medication useand use of health care services among women with polycystic ovary syndrome (PCOS).Design: Community-based prospective cohort study.Patients: Womenreporting oligo/amenorrhea and hirsutism at age 31 and/or PCOS diagnosis by age 46 (n = 280) and controls without PCOS related symptoms or diagnosis (n = 1573) in the Northern ...

ea0032oc5.3 | Reproduction | ECE2013

Age-related hormonal and metabolic alterations in women with polycystic ovary syndrome (PCOS)

Pinola Pekka , Vanky Eszter , Sundstrom-Poromaa Inger , Stener-Victorin Elisabeth , Puurunen Johanna , Piltonen Terhi , Puukka Katri , Tapanainen Juha , Morin-Papunen Laure

Introduction: PCOS-related hormonal and metabolic alterations seem to persist later in life. The aim was to investigate age-related hormonal and metabolic parameters in PCOS and in healthy women in order to determine cut-off values predicting PCOS.Subjects and methods: PCOS women and 230 healthy controls were divided accordingly: 18–24, 25–29, 30–34, 35–39, 40–44, 45–49 and >50 years. A particular interest was to analyze...