Endocrine Abstracts

Background: Intracranial Germ Cell Tumors (GCTs) are thought to originate from error of primordial germ cells migration during embryonic development, manifesting during first and second decade of life and accounts for 3-5% of all intracranial tumors.Methods: We report a case of a 22-year-old patient who presented with progressive visual loss with polyuria and polydipsia, harboring an intracranial germ cell tumor.Case presentation: ...

Background: Anecdotal evidence suggests that access to surgical care for primary hyperparathyroidism (PHPT) varies significantly across the UK.Method: A web-based survey was emailed to all members of Parathyroid UK patients’ group.Results: Replies were received from 119 patients (108F: 11M, median age 57) who have had a diagnosis of PHPT for a median for 5 years (3 months–10 years). Majority were diagnosed by the...

Objective: The objective of this study was to determine level of non-HDL and LDL cholesterol in type 2 diabetic patients with or without coronary artery disease irrespective on lipid lowering therapy and the common factors associated with elevated non-HDL cholesterol.Study design: cross-sectional study: Place and duration of study: diabetic clinic, Aga Khan University Hospital, Karachi. Data of Type 2 diabetes mellitus patients attended clinics during 20...

Case history: We present a case of a 34-year-old male diagnosed with bilateral gynecomastia referred to the endocrine clinic. Notable background of left cryptorchidism with orchidopexy at the age of 15, delayed puberty, chronic testicular pain and atopic dermatitis. On examination he had short stature, hypertelorism, low set ears, broad short hands, brachydactyly and clinodactyly of 5th fingers. There was no evidence of cleft lip/palate, teeth abnormalities or inguinal/abdomin...

Introduction: Raised intracranial pressure is a well-documented complication of obesity in the adult population, but this remains under-recognised in children and young people. The pathophysiology for this association remains unclear, but the complications of raised intracranial pressure can be devastating including potential visual loss. Therefore, the aim of our study was to investigate this link in children and young people.Method: Retrospective data ...

Objectives: to evaluate the clinical and biochemical effects of (SGLT2) inhibitors as a fourth oral anti-diabetic drug in patients with type 2 diabetes mellitus (T2DM).Patients (Materials) and Methods: In a tertiary hospital in Karachi, Pakistan, a retrospective assessment of patient medical records was conducted from January 1, 2017 to December 31, 2020.A total of 100 patients (mean age [Standard Deviation]: 53.8 [9.63] years) with poorly controlled T2D...

Background: The aim of radioiodine treatment is to ameliorate hyperthyroidism, with minimal risk of hypothyroidism. The Royal College of Physicians recommends the administration of 400–550 Mbq for Grave’s disease and 550–600 Mbq for toxic multinodular goitre.Aim: Our audit aimed to analyze the results of our current practice of radioiodine treatment, and also to compare it with the published results of success rate and hypothyroidism.<...

Research question: What are the differences in foetal size in early pregnancy between GDM and control.Methods: Serial foetal biometry was performed for GDM women and controls at 18–20 weeks and 28–32 weeks. At each visit, abdominal and head circumference (AC) & (HC), femur length (FL) and abdominal wall thickness (AWT) was measured along with collection of maternal data.Results: women with GDM and 184 controls had com...

Introduction: Hypothyroidism is a common endocrine disorder worldwide. Its treatment is with oral thyroxine, but when this route cannot be utilised then intravenous thyroxine is an alternate but not available in some countries so rectal thyroxine administration can be used but clinical experience is lacking.Case report: This is a case of a 55-years-old Pakistani male known case of hypothyroidism since July 2007 and was maintaining normal TSH and FT4...

Background: Concomitant thyroid cancer in patients with congenital thyroid dyshormonogesis (TD) is extremely rare and only few cases of differentiated thyroid cancer in patients with TD were reported in literature. We present the first case of anaplastic thyroid cancer (ATC) in woman with TD.Case: A 46-year-old female patient was referred to our hospital for thyroid surgery due to rapid tumor growing and compressive symptoms. The fine needle aspiration r...