Searchable abstracts of presentations at key conferences in endocrinology

ea0037mte10 | (1) | ECE2015

Approach to the patient with dyslipidaemia

Sonmez Alper

In clinical practice, dyslipidaemia defines the elevated plasma total cholesterol, LDL cholesterol or triglycerides or the decreased HDL cholesterol levels. In recent years however, new laboratory methods helped us understand that the functions of lipoproteins are more important than their amounts. Dyslipidaemia is one of the most important and correctable risk factors for the atherosclerotic cardiovascular diseases (CVD). The epidemiological data recurrently show a very signi...

ea0022p148 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Searching for the metabolic syndrome criteria in young adults with hypogonadism

Sonmez Alper , Haymana Cem , Bolu Erol , Tapan Serkan , Barcin Cem , Aydogdu Aydogan , Taslipinar Abdullah , Kutlu Mustafa

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

ea0041ep542 | Diabetes therapy | ECE2016

Add on exenatide treatment in obese type 2 diabetic patients under intensive insulin regiments

Sonmez Alper , Dinc Mustafa , Taslipinar Abdullah , Aydogdu Aydogan , Meric Coskun , Basaran Yalcin , Haymana Cem , Demir Orhan , Azal Omer

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

ea0020p240 | Bone/Calcium | ECE2009

The effect of short term human chorionic gonadotropin treatment on the improvement of bone mass in patients with hypogonadotropic hypogonadism

Bolu Erol , Sonmez Alper , Apikoglu Mehmet , Gurel Hasan , Emer Ozdes , Taslipinar Abdullah , Ozguven M Ali , Kutlu Mustafa

Background: Idiopatic hypogonadotropic hypogonadism is a congenital abnormality due to GnRH deficiency which is associated with severe osteoporosis. Testosterone replacement has been shown to improve the loss in the bone mass. The aim of the present retrospective analysis was to measure the effect of human chorionic gonadotropin treatment on the improvement of bone mineral density.Methods: A total number of 96 young male (mean age 21±3.7 years) pati...

ea0020p367 | Diabetes and Cardiovascular | ECE2009

The relationship between hemoglobin levels and endothelial functions in diabetes mellitus

Sonmez Alper , Yilmaz M Ilker , Zoccali Carmine , Saglam Mutlu , Kilic Selim , Uckaya Gokhan , Eyileten Tayfun , Yenicesu Mujdat , Kutlu Mustafa

Introduction: Hemoglobin (Hb) is the main carrier and buffer of Nitric oxide. Recently, an inverse association between Hb and the endothelium dependent relaxation was observed in patients with Type 2 diabetes. Testing whether this association exists also in diabetic nephropathy is important because anemia in these patients starts at an earlier stage than in other renal disease. Also, at population level diabetes and renal dysfunction, particularly albuminuria, contribute indep...

ea0056p962 | Male Reproduction | ECE2018

Hematological indices in congenital hypogonadism and the effect of testosterone replacement therapy: A retrospective study

Haymana Cem , Demirci Ibrahim , Dinc Mustafa , Demir Orhan , Akin Onur , Meric Coskun , Aydogdu Aydogan , Sonmez Alper , Azal Omer

Introduction: Patients with hypogonadism are at increased risk for cardiovascular diseases. Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are hematological indices that are surrogate markers of adverse cardiovascular outcomes. This study investigated the platelet count, MPV levels, PLR, and NLR in patients with congenital hypogonadotrophic hypogonadism (CHH) and also studied the effect of testosterone replacement thera...

ea0049ep362 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Identifiying underdiagnosed or undertreated patients with familial hypercholesterolemia from the central laboratory registries

Haymana Cem , Berlik Hamza , Gunes Yalcin , Tuncez Orhan Enes , Aytekin Cihat , Tapikara Zafer , Guzel Huseyin , Ozturk Ozlem , Barcin Cem , Ozgurtas Taner , Azal Omer , Sonmez Alper

Objective: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is globally underdiagnosed and undertreated. This study aimed to search for the demographical characteristics, awareness and treatment adherence of underdiagnosed or undertreated FH patients from the records of the central biochemistry laboratory.Methods: Patient...

ea0049ep1165 | Male Reproduction | ECE2017

Endothelial dysfunction, inflammation and insulin resistance in patients with Klinefelter Syndrome

Haymana Cem , Aydogdu Aydogan , Demirci Ibrahim , Dinc Mustafa , Demir Orhan , Torun Deniz , Yesildal Fatih , Meric Coskun , Basaran Yalcin , Sonmez Alper , Azal Omer

Introduction: The prevalence of cardiometabolic disorders such as type 2 diabetes mellitus, dysipidemia and metabolic syndrome is increased in patients with Klinefelter syndrome (KS). The mechanism by which cardiometabolic risk increases in patients with KS remains to be completely elucidated. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of KS.Methods: A total of 31 patients wi...

ea0041ep716 | Male Reproduction | ECE2016

The investigation of oxidative stress-related parameters in congenital hypogonadism

Haymana Cem , Aydogdu Aydogan , Soykut Bugra , Erdem Onur , Ibrahimov Tural , Dinc Mustafa , Meric Coskun , Taslipinar Abdullah , Basaran Yalcin , Sonmez Alper , Azal Omer

Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. The pathogenesis of increased cardio-metabolic risk in hypogonadal patients is not clear. Oxidative stress plays an important role in the pathogenesis of cardio-metabolic diseases. The aim of this study was to search for any difference of the oxidative stress parameters between in patients with hypogonadism and healthy controls.Materials and Methods: Thirty ...

ea0041ep1087 | Thyroid cancer | ECE2016

Comparisons of Endothelial Dysfunction, Inflammation and Insulin Resistance in Differentiated Thyroid Cancer Patients According to Their Radioactive Iodine Treatment Status

Dinc Mustafa , Baskoy Kamil , Yildiz Ramazan , Tapan Serkan , Alagoz Engin , Yesildal Fatih , Ozturk Erkan , Taslipinar Abdullah , Aydogdu Aydogan , Deveci Salih , Arslan Nuri , Azal Omer , Sonmez Alper

Objective: Radioactive iodine (RAI) treatment has been reported to be associated to increased cardiovascular events and death compared to the general population, but the mechanism is not fully understood. Endothelial dysfunction, inflammation, and insulin resistance play important roles in the pathogenesis of atherosclerotic events. We aimed to compare papillary thyroid carcinoma patients receiving levothyroxine suppression therapy after bilateral total thyroidectomy with or w...