Endocrine Abstracts

Introduction: Syndrome of inappropriate secretion of thyrotropin (SITSH) is a rare condition characterized by uninhibited serum TSH in the presence of high thyroid hormones, usually caused by TSH secreting adenoma or resistance to thyroid hormones (RTH). Differential diagnosis between the two is often challenging due to their overlapping features.Case report: We present the case of a 50-year-old postmenopausal woman with a history of -myocardial infarcti...

Introduction: Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death ligand 1, and its ligand (PD-1/PD-L1) have become the current standard of care for many cancers. The mechanism of action of these drugs results in some new types of adverse events related to the immune system, most frequently involving the pituitary and thyroid glands.Case report: We present a case of mixed hypothyroidism (prim...

Background: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015-2017 with the aim to assess the incidence and impact of intraoperative features that may predispose to postoperative hypoparathyroidism (PoSH).Results: 171 (30.97%) pati...

Introduction: De Quervain’s thyroiditis, also known as subacute granulomatous thyroiditis, is a self-limiting inflammatory disorder of the thyroid gland. It is presumed to be caused by a viral infection and many patients have a history of an upper respiratory infection 2-8 weeks prior to the onset of thyroiditis. It is the most common cause for neck pain or discomfort, and it usually has a predictable course of thyroid function evolution. On ultrasonography the thyroid gl...

Primary vaginal malignancy is uncommon, accounting for about 2% of all gynecological tract cancers, with small-cell neuroendocrine carcinoma of the vagina being exceptionally rare and aggressive. They display similar histological and immunohistochemical features to small-cell carcinomas of different origin. Few cases are reported in the literature so far and therefore, there is no current treatment protocol consensus. We report the case of a 34-year-old nulliparous patient, wh...

Panhypopituitarism refers to decreased production of all of the pituitary hormones of the adenohypophysis with or without deficiency of neurohypophysis function. The development of the disorder is frequently insidious and the manifestations often depend on the etiology of the condition.Case report: In October 2019 a 57-year-old man collapsed in front of the hospital after being discharged from the cardiology clinic. The day before, he had undergone angio...

Background: Renal dysfunction is known to be more prevalent amongst patients with obesity. Metabolic and bariatric surgery is associated with positive renal effects through intricate pathways. We aimed to determine the short-term impact of laparoscopic sleeve gastrectomy (LSG) on renal function and to identify parameters associated with its variation.Materials and methods: We performed a retrospective study on 268 patients (115 males and 153 females) eva...

Introduction: The aim of the study was to evaluate the relevance of autoimmunity in the cytological results for the thyroid nodules referred to FNAB (fine-needle aspiration biopsy).Materials and methods: Our study included 590 patients who underwent FNAC in 615 nodules between December 2015 and January 2019. Besides demographic data and routine endocrine investigations (thyroid hormonal status, presence of autoimmunity, the actual or past use of levothyr...

Introduction: Although calcifications are a relatively common finding on a thyroid ultrasound, present in both benign and malign lesions, osseous metaplasia (OM) is a peculiar discovery, with only a few described cases in literature so far. Common pathophysiological explanations include abnormalities of bone morphogenetic protein family members and basic fibroblast growth factor. Most of the case reports are presenting OM in association with malign lesions, often with papillar...

Background: Despite current efforts in trying to accurately identify determinants of impaired quality of life (QoL) in acromegalic patients, studies on this topic are still conflicting and more research is needed in order to improve the well-being of these patients.Methods: We conducted a cross-sectional study, administering two standardized questionnaires (AcroQol and EuroQol-5D) to 38 acromegalic patients and examined ...