Endocrine Abstracts

Aim: Medullary thyroid cancer (MTC) is 4.73 times higher among glucagon-like peptide-1 (GLP-1) agonist users. GLP-1 agonists are witheld in case of MTC or MEN. Serum calcitonin (Ct) does not increase to diagnostic level in small and nonmetastatic MTC. We report cytology and Ct wash-out results of fine-needle aspiration biopsy of thyroid nodules (FNAB) in type 2 diabetic patients receiving exenatide.Methods: Eleven male and 66 female patients (31–76 ...

Aim: Despite multiple dose injections some patients still fail achieving HbA1c target. We aimed to evaluate the effect of sitagliptin add on therapy to multiple dose insulin injections.Method: Data of 47 (seven males and 40 females) type 2 diabetic patients who had HbA1c over 7% were retrospectively evaluated. They were already treated with premix lispro or aspart insulin (n=28), glargine plus premeal regular or aspart or lispro insulin (n</...

Aim: We aimed determinants of insulin usage in pregnant women with impaired carbohydrate metabolism (ICM).Methods: We collected 164 pregnant women in any trimester who were referred to endocrinology unit due to suspicion of ICM by obstetricians. Diagnostic laboratory criteria were as follows: fasting glucose ≥126 mg/dl in first trimester; 1 hour 50 g challenge test glucose ≥180 mg/dl; any value exceeding threshold during OGTT (...

Aim: Thyrotoxicosis is a clinical status related to increased thyroid hormones. It is caused by either hyperfunctioning thyroid tissue or destruction of thyroid. Subacute thyroiditis, also known as De Quervain or granulomatous thyroiditis, is an acute inflammatory disease of thyroid causing thyrotoxicosis. Clinical and laboratory features vary according to the course of disease. In this study, we aimed to study clinical and laboratory features of the patients who were referred...

Introduction: Thyroid hemiagenesis is a congenital developmental disorder. Most cases are euthyroid although hyperthyroidism, hypothyroidism, and malignancy may develop. We present a case of hemiagenesis with Graves’ disease.Case: A 45-year-old female patient was admitted to the endocrinology ward due to nausea and diarrhoea. She had hyperthyroidism for 1 year. She did not have any family member with thyroid disease. She was already on propylthioura...

A 41 year old male patient presented to the endocrinology unit due to recurrent long bone fractures and teeth decay. His past medical history was nonsignificant for any chronic disease. He was a child of consanguineous marriage; his father and mother were first degree cousins. There were no other family members with similar phenotype or history of recurrent fractures He was 154 cm in height and weighed 58 kg. The arm span was 139 cm. Upper to lower segment ratio was 1.16. He h...

Introduction: Hypertension is associated with increased risk of vascular disease. There is possible relation between low vitamin D levels and subclinical atherosclerosis defined as increased carotid intima media thickness (CIMT). Vitamin D deficiency is defined as levels below 20 ng/ml. In this study we aimed to find out the relation between 25 hydroxy D vitamin level and CIMT and the presence of atherosclerotic plaques.Methods: A total number of 163 pat...

Introduction: Thyroid nodules are common in population. High resolution ultrasound and fine needle aspiration biopsy (FNAB) are advised as the first line diagnostic methods. Bethesda classification system is used to provide standardization of cytologic reports. We aimed to evaluate ultrasound guided FNAB results in a mild-to-moderate iodine deficient city of Turkey.Methods: The patients (n=520), who underwent FNAB between December 2011 and Decem...

Aim: Low BMD and atherosclerosis may share similar underlying biological mechanisms including higher serum phosphate and inflammation. Neutrophil-lymphocyte ratio (NLR) as a simple marker of inflammation. There are scarce data indicating improved atherosclerosis and cardiovascular events with biphosphonate and teriparatide therapy. We aimed to evaluate NLR before and after 6 months of teriparatide therapy in patients with severe established osteoporosis....

Introduction: Platelets and neutrophils take part in proliferation of cancer cells, angiogenesis, and metastasis. Studies on various cancer types showed relation between prognosis and absolute numbers of neutrophils, lymphocytes, and the ratio in-between (NLR) and platelet/lymphocyte ratio (PLR). We aimed to evaluate NLR and PLR and their relation with features of differentiated thyroid carcinoma (DTC).Materials and methods: Electronic data of 330 patien...