Endocrine Abstracts

IntroductionIn this study we present data on the long-term outcomes of treatment of patients with moderate and severe GO.Methods98 patients with GO attending our clinic for the last 13 years and received treatment for moderate to severe GO were evaluated for their long-term response to treatment. Initial decision for treatment was based on activity and severity of the disease, assessed by CAS-score and NOSPEC...

Objectives: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a validated and widely used tool for thyroid nodules triage. Studies reporting on the frequency of each Bethesda category are scarce, and there are wide discrepancies in the reported results between the various centers. Our aim was to register all cytological reports of the thyroid fine needle aspiration biopsies (FNAB) reviewed in the Cytology Department of a tertiary hospital during a calendar ye...

Background: Thyroglobulin (Tg) is a protein exclusively synthesized by follicular thyroid cells. Serum Tg levels depend on thyroid volume, serum TSH levels, gender, age, smoking, and iodine intake. Consequently, serum Tg reference range may exhibit variations among different populations. It is crucial to establish population-specific reference ranges, especially when interpreting serum Tg values in the follow-up of patients with differentiated thyroid cancer who have undergone...

Introduction: Adrenal hyperplasia is found in more than 15% of abdominal imaging procedures in adults, unrelated to endocrine disorders, especially after the COVID era. Adrenal management is consequently recommended.Aim: To retrospectively evaluate the adrenal status in terms of morphological progression and functional impairment of adrenal function, in a cohort of cases admitted at least yearly in the National Institute of Endocrinology, Bucharest, Roma...

Introduction: Assessment of adrenal insufficiency (AI) is done routinely through Synacthen test. However, the conventional high dose (250 μg) stimulation is supra-physiological, therefore 1 μg low dose test was developed.Aim: to investigate the utility of the Low-dose test vs the High-dose test, in patients with suspected central AI, in a tertiary centre of endocrinology, in the National Institute of Endocrinology, Bucharest, Romania.<p cla...

Introduction: Sleep disorders, including insomnia disorder, can affect all aspects of personal life and often occur during perimenopause, menopause, and postmenopause. Data on the number of women who suffer from sleep disorders during menopause range from 28% to 63%. Cognitive behavioral therapy for insomnia (CBT-I) is a multi-component, drug-free treatment approach that targets behavioral and cognitive factors that contribute to chronic sleep disorders. The aim of this scope ...

Context: Graves’ ophthalmopathy (GO) is a debilitating condition that affects 30% patients with Graves’ disease (GD). It is the most common extra-thyroidal manifestation of GD, but only 3-5% of GO cases are sight – threatening.Objective: To compare the thyroid and lipid profile of GD patients who developed GO vs those without GO. The second objective is to analyze the prevalence of smoking status and insufficient 25 (OH) vitamin D levels.<...

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN-1) is an autosomal dominant disorder caused by germline mutations in the MEN1 gene encoding menin. MEN1 mutations are mainly represented by deletions/insertions, nonsense, splice site or missense mutations and can be detected by DNA sequencing. MEN-1 generally includes parathyroid, adenohypophysis, and pancreatoduodenal neuroendocrine tumors.Clinical Case: Patient S., 26-ye...

BackgroundExtranodal non-Hodgkin lymphoma (NHL) is a rare condition that accounts for less than one-third of patients with NHL at diagnosis. The heart or the endocrine organs (adrenals) involvement is extremely rare.ObjectiveWe report an unusual case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma) presenting with heart and bilateral adrenal involvement.Design...

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from simple intrahepatic lipid accumulation to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). 5β-reductase (AKR1D1) is a liver enzyme that catalyses a fundamental step in bile acid (BA) synthesis. Both BAs and BA intermediates are established as potent regulators of metabolic and proliferative phenotype. We have hypothesised that AKR1D1 plays a crucial regulatory role in NAFLD and HCC. Hu...