Endocrine Abstracts

Introduction: The risk of malignancy in thyroid nodules is reported by the Bethesda system by performing fine needle aspiration biopsy (FNAB). Atypia of undetermined significance(AUS) or follicular lesion of undetermined significance(FLUS)(Bethesda 3) and suspicious for a follicular neoplasm (Bethesda 4) create uncertainty about treatment and follow-up. Molecular tests, ultrasonographic features of the nodules, and calcitonin level help us for this uncertainty. Here, we will p...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, heritable syndrome characterized by a hyperparathyroidism, pituitary adenoma and pancreatic islet cells.Case: A 56-year-old male patient had a single parathyroid excised for primary hyperparathyroidism 10 years ago. He was further investigated due to hypoglycemia and a mass was found in the head of the pancreas on MRI. It was reported as neuroendocrine tumor and no recurrence was found i...

Introduction: Langerhans cell histiocytosis (LCH) is a neoplastic histiocytic disorder that characterized by proliferation of abnormal Langerhans cells. The most typical organs affected by LCH are the skin and bones, though it can also affect the pituitary gland, central nervous system, liver, spleen, lungs, and other organs.Case 1: 36 year old man presented with polyuria, polydipsia and right hip pain lasting about 4 months. The pain increased in the la...

Cushing’s syndrome as a result of ectopic adrenocorticotropic hormone (ACTH) secretion, is associated with various tumors. Lung squamous cell carcinoma (LUSC) causing ectopic ACTH syndrome is a very rare condition. A 70-year-old male patient with a history of LUSC was admitted to our clinic for evaluation of worsening delirium and hypokalemia. Two courses of pembrolizumab were administered to our patient who was diagnosed with LUSC a month ago. At presentation, neurologic...

Tuberculosis (TB) is a disease that affects all organs and progresses with a wide variety of clinical manifestations. Cases of extrapulmonary tuberculosis (EPTB) are particularly difficult to diagnose because of its atypical course.Case: A 32-year-old female patient was evaluated in our clinic with the complaint of localized swelling in both supraclavicular regions (ScR) for one and a half months. There were no fevers, cough, or weight loss symptoms pres...

Introduction: Olfactory and gustatory dysfunction in patient with diabetes mellitus (DM) and its pathophysiology were studied in many previous studies. Some studies reported that there was a relationship between type 1 DM (T1DM) and olfactory and gustatory functions the presence of diabetic complications. However findings are limited and controversial. The aim of this study was to determine the relationship between olfactory and gustatory scores and patients with non-complicat...

Familial central or neurohypophyseal diabetes insipidus (FNDI) results from insufficient production of antidiuretic hormone arginine vasopressin, which is caused by mutations in arginine vasopressin-neurophysin II gene (AVP-NPII). In this study, we present the clinical features of a male Turkish patient with autosomal dominant neurohypophyseal DI caused by a novel mutation (p.E108D). The prospective clinical data were collected for the proband patient and his family members. T...

Diabetes insipidus (DI) is a disorder which is rarely seen and it is characterized by polydipsia and polyuria. Inadequate secretion of arginine vasopressin (AVP) from hypothalamus or inadequate response of kidney cells to AVP could be causes of DI. Therefore, any mutations in AVPR2, AVP and AQP2 genes which are the parts of that stimulation and response pathyway can cause DI. In this study, mutational analyse was performed for A45T mutation in AQP2 gene. We present a novel hom...

Aim: The lipid accumulation product (LAP) index which is associated with abnormal glucose regulation can be easily calculated. Women with polycystic ovary syndrome have more than one risk factor for the development of cardiovascular diseases such as glucose intolerance, insulin resistance and abdominal lipoidosis. In this study, we intend the evaluation of LAP index in women with PCOS.Method: This study included 35 women patients with PCOS (mean age 22.4...

Aim: In a previous study, we demonstrated elevated mean platelet volume in isolated hypogonadotrophic hypogonadism (IHH) is associated with high cardiovascular risk. Monocyte count/HDL-cholesterol ratio (MHR) is a new inflammatory marker showing cardiovascular risk. The purpose of this study is to evaluate (MHR) in men with hypogonadotrophic hypogonadism.Method: This study includes 31 men with isolated hypogonadotrophic hypogonadism without previous trea...