Endocrine Abstracts

Introduction: Self-care plays a fundamental role in the treatment and prevention of complications of diabetes mellitus (DM). The patient knowledge about DM and its potential complications are among the factors that are associated with treatment adherence. The process of understanding the disease provides the patient better communication with professionals, better metabolic and psychosocial results which may influence on their emotional well-being and quality of life.<p cla...

Introduction: Myxedematous coma is a rare endocrine emergency that settles in the absence of appropriate treatment for hypothyroidism for a long period. The severe and chronic reduction of serum thyroid hormones culminates in the insufficiency of compensatory mechanisms that maintain the physiological homeostasis of the organism. The clinical condition is severe, commonly associated with hypoxemia, hypercapnia, hypothermia, reduced cardiac output, and altered mental status.</p...

Introduction: The treatment of thyroid diseases with thionamides can cause agranulocytosis a potentially fatal side effect. The manifestations resulting from such a condition include, in most cases, infections that, if not treated immediately, have a high risk of septicemia. Therefore, the clinical presentation includes fever of unknown origin and infections such as pneumonia, tonsillitis, and abscesses. Most patients who do not receive immediate medical intervention progress ...

Introduction: Brown tumor refers to the skeletal change that develops as one of the complications of hyperparathyroidism, in which cystic and fibrous changes occur in the bone. It occurs in approximately 10−20% of patients with primary hyperparathyroidism. Parathyroid cancer is a rare cause of primary hyperparathyroidism and accounts for approximately 1% of cases. In some cases, hyperparathyroidism may be asymptomatic until it becomes a pathological fracture and may be t...

Introduction: Hemichorea-hemiballismus, secondary to hyperglycemia, is a rare but easily treatable condition that is usually associated with poorly controlled type II diabetes mellitus. Diagnosis is based on clinical assessment and imaging. Etiology includes primarily cerebrovascular diseases, metabolic, degenerative, infectious diseases, space-occupying lesions, basal ganglia damage due to drugs and toxic substances.Case: Here we report a rare case of a...

Introduction: Primary hypobetalipoproteinemia corresponds to a series of congenital disorders that have a variable incidence from 3.2% to less than 1 in 1 million, depending on the type of genetic mutation. The diseases that comprise it occur due to different types of mutations in genes that will encode important proteins at different stages of lipid metabolism. Individuals with determinant mutations of severe phenotypes, such as Bassen-Kornzweig syndrome, as known as Abetalip...

Introduction: Treatment of differentiated thyroid carcinoma (DTC) remains a challenge in the setting of locally advanced or metastatic disease refractory to radiodine (RAI) therapy. SELECT trial demonstrated that Lenvatinib improved progression free survival (PFS) comparing to placebo.Objective: Our aim is to report the efficacy and safety of lenvatinib in our population with aggressive DTC.Methods: We retrospectively reviewed the ...

Aim: Vitamin D-binding protein (DBP), also known as GC-globulin, transports vitamin D metabolites and is also a major actin scavenger. While DBP serum levels, gene polymorphisms and autoantigens have been associated with diabetes risk, the underlying mechanisms remain unknown. DBP is produced by the liver, but has recently been shown to be highly expressed in pancreatic α-cells. We therefore sought to investigate the role of DBP in α-cell identity and function using ...

Objective: The aim of our study was to determine whether there is a relationship between oxidative stress parameters and subacute thyroiditis.Material and methods: The study included 55 subacute thyroiditis patients and 30 healthy volunteers. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON) and thiol/disulfide homeostasis parameters were measured by a novel and automated assay in the patient and control groups.<p class="a...

Introduction: Cushing’s syndrome (CS) is certainly one of the most challenging disorders to physicians due to the difficulties that often appear during its investigation. The diagnosis of CS involves two steps: confirmation of hypercortisolism and determination of its etiology. Biochemical confirmation of the hypercortisolemic state must be established before any attempt for differential diagnosis. Failure to do so will result in misdiagnosis, inappropriate treatment, and...