Endocrine Abstracts

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as developmental failure of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism. In contrast, subjects presenting TH were only sporadically involved. In addition, whether the same factors are responsible for development of TH and other forms of thyroid dysgenesis is still to be elucidated. Recent stud...

Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as failure of the development of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism; in contrast, subjects presenting TH were only sporadically involved. Changes in transcription factor genes, including TTF1, TTF2 and PAX8, which play an important role in thyroid embryogenesis, have been postu...

Introduction: The admission glucose may be a predictor of survival and is independently associated with infarct size and higher mortality in patients with ACS. Hyper-homocysteinemia in patients with ischaemic heart disease represents a strong predictor of vascular morbidity. The role of glucose increase above normal levels in non-diabetic patients with ACS is not adequately defined. The aim was the assessment of dependence between admission blood glucose and homocysteine conce...

Introduction: Pituitary gland, sella turcica and parasellar region can be involved by wide variety of lesions. Diagnosis of this pathology demands a multidisciplinary effort, especially endocrinological, ophthalmologic and neurological procedures. Each of these entities has unique diagnostic and treatment considerations.Aim: Review of clinical symptoms related to sellar–parasellar region tumors and documentation of heterogeneity of clinical syndrome...

Graves disease (GD) is autoimmunological disorder leading most often to hyperthyroidism and invasive-edema opthalmopathy (Graves opthalmopathy – GO).Aim: Estimation of the relation of visual evoked potentials (VEP) results with the indicators of activity and advancement of the progress of GO.Materials and methods: The examined group consisted of 45 patients between the age of 24 and 77, hospitalized in the Department of Endocr...

Little is known about the prevalence and significance of islet cell immunity in elderly patients with type 2 diabetes. The low antibody titers against islet-cell antigens in LADA elderly patients may be a sign of a less aggressive autoimmune diabetes.The objective: To establish the changing frequency and titers of GADA and IAA in elderly diabetics.Material: 83(56F;27M)diabetic patients (60–91 y) divided in age related groups. ...

Ghrelin has been considered one of the factors that might contribute to the development of pituitary somatotropinoma.The aim of our study was to assess whether serum concentrations of ghrelin differ in patients with acromegaly treated with surgery or/and long-acting octreotide (LAO) and also to evaluate the presence of ghrelin mRNA in tissues of somatotroph adenomas. The appoval of Ethical Committee to perform the study was obtained.<p class="abstext...

Background: Prolonged exposure to excessive concentrations of GH and IGF-1 in acromegaly continues to affect patients’ appearance and negatively influences their self-evaluation, personal relations and morbidity. Besides chronic GH/IGF-1 excess could be deleterious to the brain through many mechanisms.Objectives: The aim of the study was to evaluate the influence of acromegaly on the prevalence and the severity of depressive symptoms in patients wit...

The waist-to-height ratio (WHtR) has recently gained attention as an anthropometric index showing the highest predictive value for cardiometabolic risk in PCOS and healthy women. Central adiposity is the key driving force behind a constellation of inflammatation linked to insulin resistance, metabolic syndrome and cardiovascular diseases. PCOS is also considered to be linked to chronic inflammatory processes. Platelet count ratio/mean platelet volume (PLT/MPV), lymphocyte&#150...

Introduction: Hypopituitarism can be caused by a number of different etiologic factors including metastatic cancer. Metastasis to the pituitary gland is rare, accounting for only 1.8% of all metastases, and is often detected incidentally by symptoms associated with hormone dysfunction like hyponatremia. Breast and lung cancer are the primary neoplasms with well established properties of pituitary infiltration. Metastases from gastric cancer are unusual and constitute less than...