Endocrine Abstracts

Objective: Analyze the use of DPP-4 inhibitors (iDPP4) in a specialized consultation as well as metabolic impact, weight and safety in patients with diabetes mellitus type 2 (DM2).Material and methods: We analyzed 100 patients with DM2, derivative to Diabetes hospital with debut or poor glycemic control. We initiated them sitagliptin 100 mg/day and reinforced Diabetes education. We studied the HbA1c, weight and severe hypoglycemia. Statistical analysis w...

Introduction: The relationship between SNPs of the FSHR gene and serum FSH has not been completely clarified. Genetic variants of the FSHB gene have been associated to variation in gene transcription and to serum FSH levels in men. An interesting joint effect of both FSHB −211G>T and FSHR 2039 A>G on male reproductive parameters has been recently observed. No data have been published on the effect of the FSHB −211G>T in combination with the FSHR 2039 A&...

Introduction: Hyponatremia is common in the emergency room, albeit frequently overlooked. Our objective was to describe the characteristics of hyponatremia in a cohort of emergency room patients, and evaluate how hyponatremia was studied and followed up.Material and methods: We studied all 211 patients under 70 years-of-age who presented/developed non-translocational hyponatremia (serum sodium (SNa) <135 mmol/l) during the first 48 h of their stay at...

Introduction: CLM29, a pyrazolo[3,4-d]pyrimidine compound, inhibits several targets (including the RET tyrosine kinase, epidermal growth factor receptor, vascular endothelial growth factor receptor and has an anti-angiogenic effect). Recently it has been shown to inhibit proliferation and migration in primary papillary dedifferentiated thyroid cancer cells. The aim of this study is to evaluate the anti-tumor activity of CLM29 in medullary thyroid cancer (MTC).<p c...

Excess body iron is associated with the metabolic syndrome, but whether it has a causal role in the pathophysiology of insulin resistance (IR) is not well understood. Aim of this study was to assess (a) the effect of dietary modulation of iron status on IR in Wild-type or ob/ob C57Bl/6 male mice fed a standard iron concentration (8 mg/kg) or an iron enriched diet (30 g/kg; IED), as well as in high-fructose diet (HFD) mice and (b) to investigate the mechanisms whereby. IED dete...

Objectives: Evaluate the impact of the therapy with GLP-1 analogues (exenatide) toguether with basal insulin in glycemic control and weight of patients with type 2 diabetes mellitus poorly controlled.Materials and methods: We analyzed 37 patients with type 2 diabetes with poor glycemic control and obesity, treatment with exenatide and basal insulin. As pre-treatment 56.7% of our patients were with basal insulin, 10.8% with insulin mixtures and 32.4% with...

Objective: Polycystic ovary syndrome (PCOS) is a multifaceted disease characterized by metabolic and reproductive disorders associated with hyperandrogenism and insulin resistance. Berberine (BBR) is an isoquinoline derivative alkaloid extracted from chinese medicinal herbs that has been used as an insulin sensitizer.BBR could represent a potential therapeutic tool for PCOS.The aim of this study was to evaluate the effects of BBR on the clinical, metabol...

Background: Rats on a free-choice (fc) diet of saturated fat and liquid sugar in addition to chow (fcHFHS) overeat persistently, and show increased hypothalamic neuropeptide Y and decreased melanocortin signaling, which reflects a hunger state despite hyperphagia. This response is specific for a fcHFHS diet, because when given the choice between fat and chow (fcHF) or between liquid sugar and chow (fcHS) hyperphagia is not observed. Because leptin signaling is important for th...

Objectives: Verify the efficacy of the GLP-1 analogue exenatide in patients with type 2 DM assisted in our hospital area.Material and methods: This study included patients who initiated this therapy in 2008 and 2009. Through 3 months were analyzed the outcomes of weight, HbA1c and the development of adverse effects.Results: The process included 32 patients, 21 men and 11 women, with ages between 26 and 73 years old (mean age 48.78 ...

Despite advances in the management of last years, diabetes and its complications are still the most frequent cause of admission in Endocrine Departments. Nowadays, in our Hospital, 60% of admissions are due to Diabetes, and more than a half of these are diabetic ketoacidosis (DKA) (35.4%).Objective: Analize DKA episodes in our medical area in the last 12 years and compare them divided in two periods.Methods: Divide DKA episodes in ...