Endocrine Abstracts

Introduction: Gestational Diabetes Mellitus (GDM) has been associated with complications both in the neonate and in the mother; including increased risk of Type 2 Diabetes Mellitus (DM2), obesity, and cardiovascular disease. Fibroblast growth factor 21 (FGF21) is a key regulator of glucose and lipid metabolism. Recently, the relationship between FGF21 and metabolic component diseases such as diabetes mellitus and obesity has been demonstrated. In addition, FGF21 mRNA and prote...

Objectives: Examine the relationship between choroidal thickness (CT) and renal function tests.Methods: Cross-sectional study with 42 eyes of 21 ocular treatment-naïve diabetic patients. Demographic and ocular data were analyzed as well as the following renal function tests: microalbuminuria, microalbumin/creatinine ratio and glomerular filtration rate (CKD-EPI and MDRD-4). Choroidal thickness was measured by swept-source ocular coherence tomography...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico, comprising a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indices have been proposed, such as non-invasive techniques, however there are very few studies in our population.Objetive: This study aims to compare mathematical indexes and...

: Hepatic steatosis is a common obesity-associated pathology characterized by the accumulation of fat within the liver, which can progress to liver fibrosis, cirrhosis and ultimately lead to hepatocellular carcinoma. Remarkably, obesity and cancer course with a profound dysregulation of the genetic expression patterns and, particularly, with the aberrant expression of splicing variants that could contribute to the aggressiveness and comorbidities of these pathologies. Since th...

Human chorionic gonadotropin (hCG) is the pregnancy hormone marketed as a drug for assisted reproduction technologies to support follicle-stimulating hormone action. Several hCG formulations are commercially available, differing in source, purification methods and biochemical composition. In this study, we investigated the molecular features and the intracellular signaling mediated by five urinary and recombinant hCGs. The drug comparisons were performed by quantifying the hor...

Obesity, a disease that is growing at epidemic proportions worldwide, is caused by a combination of genetic and lifestyle factors. One of the most common pathologies associated with obesity is hepatic steatosis, an accumulation of fat within the liver that can progress to liver fibrosis, cirrhosis, and ultimately lead to hepatocellular carcinoma. There is emerging evidence that alternative mRNA splicing, the key mechanism providing transcript and protein diversity, is dysregul...

Introduction: Hyponatremia is the most frequent electrolyte disorder found in clinical practice, and has been associated with increased morbimortalty. Hyponatremia is even more common among patients receiving parenteral nutricion(PN), a therapy increasingly in use. However, the morbimortality of hyponatremic patients on PN is unknown.Methods: Retrospective study, selecting all patients receiving PN in a teaching hospital from 01/11/11 to 01/06/12. We eva...

Introduction: In a majority of Spanish hospitals, serum sodium levels (SNa) are determined by indirect electrode methodology (sodium in the liquid fraction of serum) divided by the total serum volume (mmol/l). To avoid over/underestimating SNa, a formula can be applied: SNa corrected for total proteins (TP)=SNa×93 divided by (99.1−(0.7×TP)). Hypoproteinaemia is frequent in patients receiving parenteral nutrition (PN), and is probably related to surgery, acute d...

Object: Nonfunctioning pituitary adenomas can experiment recurrence and/or progression (R/P) several years after surgery in about 15–50% of patients. There is few evidence about risk factors that could predict R/P. The aim of this study is to identify them and describe our experience through a long term of follow-up in pituitary macroadenomas.Methods: Retrospective cohort analysis of 64 patients who underwent surgery between 1990 and 2013. The main ...

Introduction: Although the most common causes of hyperprolactinemia are prolactinoma and iatrogenic, another possible cause is severe primary hypothyroidism, in which the increase of prolactin is a cause of pituitary stimulation by TRH, and can be presented with pituitary hyperplasia.Case report: A 31-year-old woman who comes to endocrinology clinic for hyperprolactinemia, which was detected by symptoms of amenorrhea–galactorrhea. After normal pregn...