Endocrine Abstracts

ObjectiveThe aim of the study was to evaluate the overall malignancy rate on final histopathology in nodules with Bethesda III or IV surgically excised and review the ultrasound and cytological features givenMaterial and methodsIs a retrospective analysis of patients referred to our outpatient clinical of endocrinology after thyroid surgery with a previous thyroid nodule FNA cytology in Bethesda III or IV cat...

BackgroundThe prevalence of malignancy among Bethesda category III (atypia of undetermined significance) cytologies is variable in different studies.ObjectiveThe aim of this paper is to evaluate the risk of malignancy of thyroid nodules classified as Bethesda III in our hospital.MethodsWe have reviewed the medical records of 146 patients who underwent FNA with Bet...

IntroductionThe choice of a specialty in medicine is a decision that is imposed on new graduates. The aim of our study was to assess the perception of the specialty of Endocrinology and Nutrition among a large sample of medical students in their final year of their degree or prior to taking their Medical Internship Examination in order to know if they would choose Endocrinology and Nutrition for their specialised training, as well as the most and least a...

Craniopharyngiomas are rare benign epithelial tumors derived from remains of Rathke’s pouch. They are more prevalent in childhood, adolescence, and adults <50 years, and, commonly, are usually diagnosed after being associated with serious comorbidities when the development of the tumor is already advanced. To date, first-line therapy is usually surgery, but frequently the resection is not complete, causing high rates of recurrence. Therefore, the identification of ne...

Obesity is a chronic metabolic disease associated with important metabolic and inflammatory comorbidities, which can be reversed or improved after bariatric-surgery (BS). However, some underlying mechanisms, independent of weight-loss, are still unknown. In this context, dysregulations in the inflammasome, a multiproteic complex that promotes cytokine maturation and induces cellular pyroptosis, has been associated to the development/stage of some cancer-types and obesity. Howe...

Introduction: Gonadotroph tumours (GT) are the most common subtype of silent pituitary neuroendocrine tumours. The diagnosis of this subtype of tumours is established after surgery. There are no reliable markers of aggressiveness to predict their clinical course and, moreover, immunohistochemistry (IHC) usually classifies GT as null cell tumours. The aim of the present study was to correlate molecular, immunohistochemical and biochemical gonadotropin expression, to quantify th...

Retinoic acid (RA) treatment has been used in the last decade for redifferentiation of metastatic thyroid cancer that have lost radioiodine uptake (RIup) with heterogeneous results.Aim: To evaluate the improvement of RIup after a course of RA treatment.Method: Retrospective analysis of 29 patients with radioiodine negative metastatic disease (17 men /12 women; 22 papillary, 4 follicular and 3 oncocytic tumours). RA was given at a d...

Somatostatin (SST), Cortistatin (CORT), Neuronostatin (NST) and their receptors [SST/CORT-receptors (sst1–5/sst5TMD4-TMD5) and NST-receptor (GPR107)] comprise a hormonal pleiotropic system involved in the regulation of multiple pathophysiological functions. Certain components of this system are dysregulated in endocrine-related cancers, including prostate cancer (PCa), wherein we have found that alterations in specific components of this regulatory system [i.e. NST-GPR10...

Pancreatic neuroendocrine tumors (panNETs) comprise several neoplasms in which a precise diagnosis and therapeutic treatment are hampered by their diversity and heterogeneity which in turn, hind the identification of common molecular signatures and the development of efficient therapeutic approaches. Subsequently, there are no clinical, biochemical, anatomopathological, immunohistochemical or molecular features capable to currently predict either tumor prognosis or post-surgic...

BackgroundBioelectrical impedance analysis (BIA) has been widely used in the evaluation of body composition. Phase angle (PhA) is obtained from the direct measurements of resistive (Rz) and reactive (Xc). Pha and can be interpreted as an indicator of fluid distribution, electric resistance and cellular membrane capacitance of the human body, and is associated with nutritional status. Its screening, and an early intervention in patients with a low PhA, ma...