Endocrine Abstracts

Background: This study examined the associations between body mass index (BMI) and falls in Korean adults using data from a large population-based survey.Methods: We analyzed 113,353 men and women (aged ≥50 years) who participated in Korean Community Health Survey in 2013. The BMI groups were classified as underweight (<18.5), normal weight (18.5≤ BMI< 24.9), overweight (25≤ BMI< 29.9), and obese (≥30). Logistic regres...

Introduction: Hypoxia-inducible factors (HIF) are the key transcription factor induced by hypoxic condition, which regulate expression of specific target genes including angiogenic factors, erythropoietin, glucose transporters, and glycolytic enzymes. Recently, many studies connected to intracellular calcium levels and regulation of HIF-1α protein level. Calbindin-D9k is a cytosolic calcium-binding protein and compensate with other calcium transporter protein f...

Objective: Sarcopenic obesity is a double burden for older people because it carries the cumulative risk of functional abnormality, metabolic, cardiovascular risk, and mortality compared to either sarcopenia or obesity alone. Diabetes is related to an increase in visceral adiposity and is associated with the risk of sarcopenia. The objective was to explore the association between sarcopenic obesity and diabetes and determine the associated factors with sarcopenic obesity in ol...

Background: Many studies indicated an increased cancer incidence and cancer mortality in subjects with diabetes mellitus. But most of studies have been surveyed in western countries and have problems in applying the results to Korean. We aimed to evaluate the site specific cancer risk of diabetic patients in Korea over 30 years, and investigate causal relationship and temporal relationship by analyzing the organ-specific cancer risk in diabetics according to duration.<p cl...

Objective: Dapagliflozin, sodium-glucose cotransporter-2 (SGLT-2) inhibitor, reduces hyperglycemia and body weight by inhibiting renal glucose reabsorption. However, only a few studies have shown the efficacy of dapagliflozin in type 2 diabetic patients. We evaluated the efficacy and safety of body weight reduction of dapagliflozin in real practice with type 2 diabetes in Korea.Methods: This is a retrospective, observational study, data from 61 patients ...

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been associated with several human metabolic disorders and is converted from inactive 11-keto form to glucocorticoid (GC or cortisol). GC overproduction or hypercortisolism is a major diagnostic factor of Cushing syndrome and Anorexia. GCs regulate carbohydrate, fat, and protein metabolism.Materials and methods: Previously we established porcine fibroblasts overexpressing 11&#...

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. In previous study, demonstrated that endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) and Octylphenol (OP) could cause increase in insulin level and insulin transcription factors. But in regulations of plasma glucose level were not decreased as much as...

Introduction: Phthalates are chemicals used to improve the plasticity of industrial polymers and used in commercial products such as toys, paints, packaging materials, medicals devices and personal care items. Phthalates, endocrine disrupting chemicals, have been documented to cause adverse effects to the human health such as breast cancer in female, reduced uroogenital distance and changed the expression of steroidogenesis and folliculogenessis. In this study, we investigated...

Background: Distant metastasis rarely occurs in differentiated thyroid carcinoma (DTC), but represents most common cause of death in patients with DTC. Lung and bone are the most frequent sites of distant metastases. This study investigated long term outcomes of lung metastasis in DTC patients and its prognostic factors influencing disease progression and cancer specific survival (CSS).Methods: A total of 134 DTC patients presenting with lung metastasis ...

Olfactory neuroblastoma (ONB) is a rare neuroendocrine tumour arising within the sino-nasal cavity. It occurs world wide, affecting both sexes, all ages and all races with no underlying predilection having yet been identified. ONB exhibits a range of phenotypes from indolent to very aggressive, and up to 5% cases are associated with ectopic hormone secretion. Despite current gold-standard treatment of surgical resection (either endoscopic or craniofacial resection) followed by...