Endocrine Abstracts

Objective: To study the differences in the metabolic profile of patients with non-functioning adrenal adenomas (NFA) and autonomous cortisol secretion (ACS).Methods: 143 patients diagnosed of adrenal incidentaloma (AI) between 2010 and 2018 were retrospectively analyzed. AI was defined as an adrenal mass≥1 cm, accidentally discovered by radiologic examination. ACS was confirmed by serum cortisol post-dexamethasone suppression test (Nugent)≥3 ...

Introduction: Few studies have evaluated the impact of type 2 diabetes on the prognosis of acute heart failure (HF). This study assessed the effect of diabetes and glycemic control on complications, hospital stay and prognosis in patients with acute HF.Methods: Retrospectively, databases of 428 hospitalized patients by acute HF were analyzed, 201 diabetic patients and 227 controls. Statistical analysis was done using SPSS, considering statistical signifi...

In liver, melatonin (Mel) and glucocorticoids (GC) influence the systemic energy homeostasis. Animals without pineal gland present impairment in glycemic control, as in type-2 diabetes. In turn, Mel reduces the GC levels, particularly in nocturnal animals. We aimed to evaluate the influence of Mel, as well as GC receptor blockade by RU486 treatment on hepatic and pancreatic energy metabolism. Male Wistar rats were subjected to surgical removal of pineal and, 25 days after the ...

Introduction: Pheochromocytomasand paragangliomas are tumors derived from chromaffin cells which result from mutations of at least six different genes as autosomal dominant disorders.Aim: To evaluate the existence of correlations between genetic alterations and clinical data in 16 patients with pheochromocytomas and/or paragangliomas.Methods: From 2007 to 2009, 13 patients with pheochromocytoma [3 men, medium age 39 years (14&#8211...

PurposeTo evaluate the prevalence of bilateral macronodular adrenal hyperplasia (BMAH) in patients with adrenal incidentalomas (AIs) and analyse the differential phenotype of patients with BMAH compared to other bilateral adrenal lesions which do not meet BMAH definition (non-BMAH), with associated possible or confirmed autonomous cortisol secretion (ACS).MethodsRetrospective study of patients with AIs diagno...

IntroductionEctopic Cushing’s syndrome (ECS) is a rare entity caused by ACTH secretion by a non-pituitary tumor. The management of these patients is challenging due to its low frequency and limited experienced. The objective of this study was to describe the patients with ECS treated in the Division of Endocrinology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last six years.Methods<p class="abstext...

Introduction: In the geographical area of southern Spain, in the province of Huelva, we have detected prevalent cases of Dunnigan’s partial hereditary lipodystrophy. The genealogy, the suspicion phenotype and the coordination with the Genetics Service and Reference center, have borne fruit, and more and more families are detected in Our Area. The lipodystrophies, in general, are rare diseases that affect the adipose tissue, disappearance of it in different parts of the bo...

Objective: To evaluate the real-world experience of patients with generalized (GL) and partial (PL) lipodystrophy initiating treatment with metreleptin as part of an early access program (EAP).Methods: A retrospective data collection was conducted from four countries for patients enrolled in the EAP. A descriptive analysis was performed on selected patient characteristics, baseline organ impairments and complications, and response to metreleptin therapy,...

About 10–15% of prolactinomas (P) are resistant to Dopamine agonists (DA). We analyzed retrospectively ten resistant prolactinomas (RP) treated at our center between 1995 and 2014, to identify useful variables to predict DA resistance and its different patterns (biochemical resistance (BR), morphological resistance (MR) or both). BR is defined as the failure to normalize prolactin (PRL) levels with ≥ 2 mg/week of cabergoline (C) for at least 3 months. MR is consider...

Introduction: Glutamic acid decarboxylase (GAD65) is expressed by pancreatic beta cells and also by GABA (gamma-aminobutyric acid)-secreting neurons. Cerebellar ataxia associated with anti-GAD65 antibodies (antiGAD Ab) is a rare neurological disorder that frequently coexists with other autoimmune conditions, namely Diabetes Mellitus (DM).Case reports: We describe two cases of ataxia associated with antiGAD Ab. The first case is a 69-year-old obe...