Endocrine Abstracts

Diabetes is associated with a greatly increased risk of cardiovascular disease and the advanced glycation end products (AGEs) and their receptors play an important role in these complications.Objective: To study the association between AGEs and sRAGE levels with cardiovascular risk factors in obese and non-obese newly diagnosed type 2 diabetic patients.Material and methods: We conducted a cross-sectional study in subjects with type...

In obesity the combined effects of enhanced food consumption, enhanced oxidative stress and inflammation could increase levels of advanced glycation end products (AGEs) and the action of their receptors.Objective: To study circulating levels of AGEs, soluble RAGE and AGER-1 and their association with insulin resistance and inflammation in young subjects with obesity and normal weight.Material and methods: We conducted a cross-secti...

Objective: To investigate factors associated with the presence and growth rate of thyroid nodules(TN) in patients with acromegaly.Methods: We retrospectively evaluated the medical records of 52 patients with acromegaly followed in our institution (University Hospital Ramón y Cajal). The frequencies of TN and papillary thyroid cancer (PTC) and potential factors associated with nodular thyroid disease (NTD) were investigated. In patients with NTD (<em...

The Barraquer-Simons syndrome is a rare form of partial symmetric lipodystrophy with involvement of the face and upper body, of unknown cause, characterized by loss of subcutaneous fat in the face and started stretching for the upper body.Case report: Female patient, 26 years old, presenting morphologic change in facies, chest, upper limbs, lower limbs and abdomen since she was 10 years old. Last year, she has increased weight at 30%, with apparent muscl...

Introduction: The increasing incidence of type 1 diabetes (T1D) is a matter of concern because it negatively impacts both the quality of life and its duration, due to the great morbidity and mortality caused by its chronic complications.Objective: To evaluate clinical care provided to Brazilian youths with T1D in daily practice, according to the American Diabetes Association’s guidelines.Methods: This was a cross-sectional, mu...

Short bowel syndrome (SBS) is a complex disease, occurring after extensive resection of the small intestine, leading to malabsorption of nutrients and fluids. Lipids storage significantly affects bone maintenance. Caloric restriction promotes bone and adipose tissue (AT) loss but marrow adipose tissue (MAT) expansion. SBS is a condition strongly associated with malnutrition; patient survival initially depends of caloric replacement through parenteral nutrition (PN). The presen...

Introduction: The availability of the body’s most abundant amino acid, glutamine is compromised in obesity-associated diabetes. This may impair glucose metabolism by increasing hepatic insulin resistance, oxidative stress and the development of nonalcoholic fatty liver disease (NAFLD).Objective: Evaluate the effects of free and dipeptide (DIP, L-alanyl-L-glutamine) forms of L-glutamine on glucose metaboli...

Cretinism and neurological impairment are related to primary hypothyroidism (PHT) while children with central hypothyroidism (CHT) are usually diagnosed during the investigation process for short stature.Objective: To describe two children with unusual presentation of CHT.Case 1: Baby girl, born after 38 weeks of gestation, weighing 3000 g, and measuring 49.5 cm long was admitted when 3 months old. The parents reported stunted neur...

Introduction: Current guidelines propose temozolomide (TMZ) as the first-line chemotherapy for aggressive pituitary neuroendocrine tumors (PitNETs), but no clinical trials have been conducted and clinical experience in this context is limited.Patients and methods: A retrospective study of patients with aggressive pitNETs treated with TMZ was conducted by the members of the Neuroendocrinology Working Area of the Spanish Society of Endocrinology and Nutrit...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...