Endocrine Abstracts

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a B7-binding protein that plays an important role in the down-regulation of T-cell activation. CTLA-4 function is closely associated with predisposition to autoimmune diseases. A native soluble form of CTLA-4 (sCTLA-4) is reported to be present in the sera of patients suffering from autoimmune thyroid disease. In this study we report data on sCTLA-4 concentrations in patients with clinical expression of Graves’ disease.<p c...

Background: Polycystic ovary syndrome (PCOS) is a heterogenous endocrinopathy commonly diagnosed in reproductive age women, predisposing to the development of metabolic disturbances. However, the mechanisms underlying the connection between PCOS and metabolic disorders are still not well understood. The aim of the study was to investigate amino acid (AA) profile in women with PCOS and to assess its relation with metabolic disturbances.Methods: 326 women:...

Objective: The purpose of the study was to investigate osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANK-L) levels in acromegaly patients with regard to the disease activity. The associations between OPG, RANK-L and random growth hormone (GH), insulin-like growth factor 1 (IGF-1), lumbar spine (LS) bone mineral density (BMD), femoral neck (FN) BMD were also evaluated.Methods: A study group included 72 patients with acrom...

Introduction: Sclerostin is well-known as an inhibitor of bone formation but also promotes bone resorption. Acromegaly is a disease characterized by increased bone turnover and higher vertebral fracture risk.Purpose: The aim of the study was to determine sclerostin levels in acromegaly patients with regard to the disease activity. We also evaluated the associations between sclerostin and random growth hormone (GH), insulin-like growth factor 1 (IGF-I), l...

Objectives: Amino acids (AA) plasma profile is associated with cardiometabolic diseases (CMD), predicts diabetes mellitus type 2 (DM2) and cardiovascular diseases (CVD) many years in advance. Metabolic syndrome (MS) defines the area of metabolic disturbances that precede DM2 and CVD development. The primary objective of the study was to examine the association between BCAA (branched chain amino acids), AAA (aromatic amino acids) profile and MS’s phenotype and to evaluate ...

Background: The association between fat mass and obesity-associated gene (FTO) polymorphism rs 9939609 and obesity was found in some European countries. However, the data concerning Polish population is insufficient. The relationship between FTO and metabolic disorders remains unclear.Methods: The study group consisted of 686 women and 418 men from Lower Silesia in Poland, aged 30–80 years (mean age 54.2±9.26 years). The examination included an...

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

Irisin (Ir), a recently identified adipomyokine, cleaved and secreted to the circulation from the FNDC5 protein in response to physical activity and some environmental conditions has been postulated to induces the differentiation of a subset of white adipocytes into brown fat and mediates the beneficial effects of exercise on metabolic homeostasis. Polycystic ovary syndrome (PCOS) – one of the most frequent endocrinopathies affecting women of child-bearing age is associat...

Brown adipose tissue metabolism is of remarkable pathophysiological interest, because it could be a target for future therapies for obesity and metabolic syndrome. Irisin (Ir), recently identified novel adipomyokine is essential in a white-to-brown fatty tissue transdifferentiation, and mediates some of the positive influences on metabolic disorders through increase of energy expenditure. The exact regulation of Ir secretion and action is unknown but significant positive assoc...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has a wide variety of nonspecific symptoms from other organs that may mimic other diseases and delay the diagnosis. Nowadays PHPT evolves to less-symptomatic.Aim: The aim is to revise symptomatology profile of PHPT in a single region of Poland; and to help early PHPT diagnosis – encouraging interdisciplinary contact between me...