Endocrine Abstracts

Introduction: Mutations in FSHβ gene leading to isolated follicle-stimulating hormone (FSH) deficiency are very rare and the disorder is inherited in an autosomal recessive manner. Up to date, only few case reports have been described in the literature.Case report: 25-years old woman was admitted to the Endocrinology Department with a suspicion of FSH deficiency. She was firstly diagnosed with primary amenorrhoea and impaired pubertal development at...

Some individuals with normal weight but probably visceral fat excess, called Metabolically Obese Normal-Weight (MONW), have disturbances typical for metabolic syndrome. We analyzed relationships between body fat distribution (estimated by DXA) and insulin resistance, serum inflammatory markers levels (CRP, IL-6, IL-18) and polymorphisms of IL-6 promoter and PPARγ in healthy, non-obese Polish subjects: 232 women (age 31.4±5.5; BMI 21.5±2.5) and 199 men (age 30.3&...

Objectives: Graves' disease (GD) is an autoimmune disease caused by combination of environmental and genetic factors. The CTLA-4 gene is a candidate gene for conferring susceptibility to thyroid autoimmunity. Increased serum level of soluble isoform of CTLA-4 molecule (sCTLA-4), resulting by alternative splicing, was found in some autoimmune diseases. The role of this molecule in the pathomechanism of autoimmunity has not been defined.The principa...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...

Background: Sclerostin is a protein secreted by osteocytes, that inhibits Wnt/ βcatenin signaling and was suggested to play a role in glucocorticoid-induced osteoporosis in mice. In humans data are inconsistent. Patients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.Aim: The aim of the study was to evaluate sclerostin concentrations, densitomet...

Objectives: SARS-Cov2 infection can lead to severe cytokine storm especially in obese patients. It is known that the cytokine storm might lead to severe clinical manifestations or even acute mortality in critically ill patients with COVID-19. Ghrelin as well as leptin can act as the proinflammatory cytokines. The essential question is whether the cytokine storm in COVID-19 patients with obesity is associated with adipokines dysregulation.Aim: The st...

Objective: To measure the levels of 25-hydroxyvitamin D (25(OH)D) and vitamin D binding protein (VDBP) and assess their relationships with metabolic features in patients with the polycystic ovary syndrome (PCOS).Methods: 267 women, aged 20–35 years (24.7±4.9): 167 with PCOS, 100 healthy women as a control group were studied. Study groups were divided according to body mass index (BMI). Biochemical and hormonal parameters, 25(OH)D, VDBP were mea...

Background: The Phase III PAOLA study assessed the efficacy and safety of pasireotide LAR versus continued treatment with octreotide LAR or lanreotide Autogel in patients with uncontrolled acromegaly. The current analysis investigated overall baseline characteristics and response rates to pasireotide according to co-morbidities.Methods: Patients were classified into five groups of co-morbidities related to acromegaly: glucose- (n=104), endocrine...

Results of metabolomic studies showed the relation of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) with metabolic disorders.Basing on this observation we assessed amino acid profile in 286 professionally active men (aged 36–60 years). 141 of them met the criteria of metabolic syndrome (MS) and remaining 142 served as controls.Quantitative analysis of BCAA (leucine-LEU, valine-VAL, isoleucine- ILE) and AAA (...

Introduction: Acromegaly is a rare diseaseresulting most commonly from pituitary adenoma. A chronic increase of growth hormone (GH) and insulin-like factor 1 (IGF-1) leads to many systemic complications including osteoporosis and fractures. Radiofrequency echographic multi-spectrometry (REMS) is a new non-ionizing technique to diagnose osteoporosis.Purpose: The objective of the study was to evaluate bone mineral density (BMD) by REMS in patient...