Endocrine Abstracts

Tumours of the pituitary gland and sellar region represent approximately 15% of all brain tumours. The most common tumours are by far pituitary adenomas, confined to the sella. However, several types of tumours may involve the sellar region, reflecting its complex anatomy. The differential diagnosis of nonpituitary sellar masses is broad and includes inflammatory and infectious diseases, cell rest tumours, germ cell tumours, lipomas, gliomas, meningiomas, metastatic tumours, a...

There are a wide range of tests to measure insulin sensitivity. Alternative techniques for estimating insulin sensitivity include measurements made during the oral glucose tolerance test (OGTT). We aimed to describe the weekly intraindividual daily variability of measures of insulin sensitivity indexes (HOMA-IR, QUICKI, Matsuda’s insulin sensitivity index (ISIM), Insulinogenic Index, Early C Peptide, Stumvoll’s Insulin Sensitivity Index (ISIS), OGIS_120)...

The prevalence of obesity markedly increased in the last 2 decades. This have asserted researchers’ attention to the role of adipose tissue throughout the pathophysiology process of a number of diseases. Fatness, namely abdominal fat, is a risk for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Physical activity is recommended as one of treatment options for individuals with T2DM. This study aimed to determine the relationship between in...

Introduction: Prolactinomas are the most common pituitary adenomas. Several authors hypothesized that there is an association between the development of pituitary adenomas and psychologically significant experiences, especially traumatic ones. This is particularly well-established for Cushing’s disease. When it comes to prolactinomas, it was suggested that prolactin acts as an alternative to cortisol in the response to stress, especially in patients who present with passi...

Introduction: Acromegaly, a rare disorder resulting of tumor GH excess, is frequently associated with prognathism and facial dysmorphia. Characteristics and mechanisms responsible for the malocclusion and the craniofacial changes in acromegalic patients (ACR) are not clarified.Aims: To evaluate the craniofacial changes in an acromegalic group.Methods: We observed 59 individuals, 33 with ACR and 26 controls with nonfunctioning pitui...

Introduction: High prolactin levels may have several etiologies including the presence of a prolactin producing pituitary adenoma or the treatment with drugs of different classes. Certain physiological states, from which pregnancy stands out, are also characterized by elevated levels of prolactin.Case: Woman, 28 years old, with no relevant medical history or chronic medication apart from oral contraceptives, begins with amenorrhea in May 2010, without ga...

Introduction: The combination of two or more, autoimmune, endocrine dysfunctions defines the presence of polyglandular syndromes.Case report: Female patient, 43 years old, history of type 1 diabetes for 23 years and autoimmune hypothyroidism for 7 years, with no other relevant clinical history and without family history of autoimmune endocrinopathies. She was under therapy with insulin and levothyroxine. She came into the Endocrinology Department in May ...

Introduction: XX male syndrome is a disorder of sex development associated with a 46, XX karyotype and is characterized by such features as: small testes, hypergonadotropic hypogonadism, male external genitalia, gynecomastia and azoospermia. The estimated prevalence is 1/20.000 males. Gender role and gender identity are reported as male. Identification and subsequent treatment is necessary to avoid the manifestations of testosterone deficiency.Clinical C...

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

Introduction: Arthropathy affects the majority of acromegalic patients and is a major cause of morbidity, absenteeism and impaired quality of life. GH excess and increased levels of circulating IGFI result initially in a marked thickening of the soft tissues and cartilage. Along with disease progression, there’s subperiostal bone neoapposition, cartilage regressive phenomena and bone structural changes. We aimed to investigate prevalence, clinical presentation, treatment ...