Endocrine Abstracts

In Portugal, no relevant epidemiologic data exists relative to the management and level of control of diabetic patients.TEDDI, a non-interventional cross-sectional study, allowed to characterize the usual management of type 1 (T1D) and type 2 (T2D) diabetes using a standardized questionnaire in 1775 patients (F: 47.5%; T2D: 80.8%) aged 18 years or older, visiting their diabetes specialist (n=180).Data was obtained for metabo...

Background: The androgen-secreting tumors constitute fewer than 1% of ovarian tumors. Leydig cell tumor is one of the most common of this type of lesion and it is usually benign, small and unilateral.Case report: A 67-year-old women was referred to the Endocrine clinic due to hirsutism (score 22 Ferriman–Gallwey) and male type alopecia with 3 years of evolution and progressive worsening. Biochemically she had high levels of serum testosterone –...

Introduction: Lipodystrophies are a group of genetic or acquired diseases characterized by abnormal adipose tissue deposition, frequently associated with insulin resistance, diabetes mellitus, dyslipidaemia, hypertension and hepatic steatosis. Congenital generalized lipodystrophy (LCG) is a well-defined syndrome with autosomal recessive heredity, prevalence <1:10million, with about 400 cases being described. Extreme shortage of subcutaneous adipose tissue, muscle hypertrop...

Objectives: To study the association of functional polymorphisms at DHFR, CBS and MTHFR genes with bone mineral density (BMD) and metabolic parameters of bone remodeling.Materials and methods: BMD (g/cm2) was measured by DEXA in 391 subjects: 174 with normal BMD (137F 37M; age=48.79±12.99 years; BMI=29.61±5.22 kg/m2), 62 with osteopenia (48F 14M; age=56.06±12.96 years; BMI=27.64±4.94 kg/m2) and 154 with osteoporosis (119F, 35M; age=64...

Background: Diabetes is an important risk factor for major adverse cardiovascular events (MACE). Although the increased risk for MACE is well known, the impact on the in-hospital outcomes remains incompletely understood. Our aim was to evaluate the interrelation between diabetes and MACE in a central hospital in the North of Portugal between 2009 and 2015.Methods: We evaluated retrospectively the hospitalizations due to MACE including stroke or transient...

Background: Pregnant women with gestational diabetes (GD) have a higher risk of perinatal complication compared to women without. Nevertheless, in women with GD, predictors of perinatal complication are not well established. We aimed to compare, in women with GD, those with and without perinatal complications and to study predictors of perinatal complications in women with GD.Methods: Retrospective study of pregnant women followed in the Endocrinology cl...

Introduction: Adipose tissue disturbances (lipodystrophy and obesity) are prevalent in patients infected with HIV. Our aims were to evaluate the prevalence of obesity and the association with lipodystrophy, the effect of gender, age, viral replication, duration of disease and cART in a population of HIV patients under cART.Methods: In this retrospective study, 580 patients were included. The characteristics of the population are presented through percent...

Introduction: Subacute thyroiditis is usually a self-limited pathology, possibly of viral aetiology, defined by cervical pain and sometimes systemic symptoms. Its association with autoimmune diseases doesn’t seem to be more frequent than in the general population.Clinical case: Clinical findings of thyrotoxicosis with 3 weeks of evolution associated with anterior cervical pain and fever up to 38 °C. The patient presented with recurrent mouth so...

Introduction: Lenvatinib is a multitarget tyrosine kinase inhibitor that has shown substantial efficacy in patients with progressive radioiodine refractory thyroid cancer (RAIRDTC) (progression free survival (PFS) 19.4 months and objective response rate 64.8%; SELECT trial) despite common adverse events (AEs).Objective: To evaluate efficacy and toxicity of lenvatinib treatment for RAIRDTC in daily clinical practice.Methods: Retrosp...

IntroductionHypoparathyroidism still remains the only hormone-deficiency related disorder whose standard treatment is not based on replacing the missing hormone. In the last few years, there has been growing evidence on the use of recombinant human PTH, mostly with subcutaneous injections of rhPTH(1–34). More recently, some clinicians have tried to administer teriparatide through a continuous delivery system using insulin pumps.<p class="abstext...