Endocrine Abstracts

Introduction: Pendred syndrome is a rare autosomal recessive disease and the classic triad is congenital sensorineural hearing impairment, goiter and impaired iodine organification with abnormal perchlorate discharge test, but hypothalamic tumors are not a feature of this syndrome.Case report: We report a case of a 32-year-old female with Pendred syndrome confirmed by genetic testing and perchlorate discharge test, with goiter, hypothyroidism treated wit...

Background: Apart from signs of hyperprolactinaemia, patients with macroadenomas with extrasellar extension generally seek medical attention due to mass effect. Macroprolactinomas, particularly in men, may occasionally exhibit a very aggressive clinical course.Case report: Male 37 years old that went to a Neurology consultation complaining of progressively more frequent self-limiting episodes of restraint, silence and time and space disorientation in the...

Background: Sézary syndrome (SS) is a more aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL). Bexarotene (Targretin) is a synthetic rexinoid analogue designed for the treatment of advanced stages of cutaneous manifestations of CTLC. Bexarotene selectively suppresses thyrotropin secretion and up to 40% of patients develop reversible idiopatic central hypothyroidism. Severe mixed dyslipidemia may be present in up to 70%.Case report: Seve...

Aims: To examine whether treated autoimmune thyroiditis (AIT) and Graves’ disease (GD) are associated with increased cardiovascular risk factors.Patients and methods: We analysed the levels of total cholesterol (TC), HDL, LDL, triglycerides (TG), ApoB, ApoA1, Lp[a], homocysteine, CRP, folic acid and vitamin B12 in 50 patients with GD and in 130 patients with AIT, after normalization of thyroid function. Patients with GD were treated with propylthiou...

Objective: The aim of this study was to examine the hypothesis that thyroid function, in euthyroid subjects with autoimmune thyroiditis (AIT), is associated with insulin resistance, serum lipid concentrations, and other cardiovascular (CV) risk factors. Subjects and Methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the Homeostasis Model Assessment for insulin resistance (HOMA-IR), the Quantitative Insulin Sensitivity Check Index (QUICKI), ...

Introduction: Incidental diagnosis of thyroid nodules has increased in recent years, leading to thyroid cancer diagnosis inflation. Nonetheless, mortality rate for thyroid malignancies remains very low, suggesting that its treatment is unlikely to affect the overall prognosis in the majority of cases. Several thyroid imaging scores have been proposed to reduce unnecessary invasive diagnostic procedures. Our aim was to verify the usefulness of the EU-TIRADS score on sparing thy...

Introduction: Obesity is nowadays one of the most important challenges in public health and, therefore, the investigation of their causes is most relevant. Among the various behavioral roots of obesity, the emotional over ingestion determined by emotional factors, i.e. emotional eating (EE), is one of them.Objectives: To study how emotions contribute to obesity in woman.Methods: We gathered a convenience sample 220 woman in the hos...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

Introduction: Antithyroid drugs (ATDs) are generally safe and well tolerated, however, major side effects such as hepatotoxicity and agranulocytosis may occur and patients should be provided information on the major symptoms of these conditions. Although rare, agranulocytosis appears to be more likely with propylthiouracil (PTU) at any dose than with low-dose Methimazole (MMI). Clinical Case: We describe the case of a 70-year-old woman referred to Endocr...

Introduction: Ectopic ACTH production accounts for up to 20 percent of ACTH-dependent Cushing syndrome (CS). Small cell carcinoma and carcinoid of the lung represents half of its cases. These patients lack some of the more obvious clinical features of cortisol excess. Therefore, this can cause a delay in the diagnosis of CS and these patients may be at high risk of life-threatening complications such as infections or thrombosis.Clinical case: Case of a 7...