Endocrine Abstracts

Introduction: Post-surgical hypoparathyroidism is a well known complication of total thyroidectomy. It may occur as transitory hypoparathyroidism that spontaneously recover within a few weeks/months and as permanent hypoparathyroidism needing long-term treatment. Only few cases of hypoparathyroidism newly diagnosed many years after surgery have been reported. We present a patient with hypoparathyroidism that became clinically evident 15 years after the thyroid surgery.<p c...

Introduction: LH receptor plays an important role in sexual development and reproductive function. Mutations of this receptor lead to the development of three clinical conditions: Leydig cell hypoplasia, hypergonadotropic hypogonadism with primary amenorrhea and familial male limited precocious puberty. The first two entities result from inactivating mutations. In Leydig cell hypoplasia, with autosomal recessive inheritance, the phenotypic spectrum correlates with the degree o...

Background: Generously supported by IPSEN)-->Pituitary abscess is a rare but potentially fatal entity. It represents ~0.2–1% of all pituitary lesions. The symptoms are usually nonspecific. The proper interpretation of imaging studies is of extreme importance to the differential diagnoses.Case: Man, 40 years old, begins complaining of occipital headache (25.04.2011), initially with good response to treatmen...

Introduction: Catecholamine-secreting tumors (pheochromocytomas and paragangliomas) are rare intra and extra-adrenal neoplasms, probably occurring in less than 0.2% of patients with hypertension. Serious morbidity and mortality rates are associated with these tumors which are related to the effects of catecholamines on various organs, especially those of the cardiovascular system.Methods: We reviewed the cases of pheochromocytomas and paragangliomas that...

The wide variability of analysis obtained from the fine needle aspiration cytology (FNAC) of thyroid nodules is attributed to experience differences in their interpretation. It is known that reproducibility is a critical parameter for the clinical usefulness of a diagnostic test. However, interobserver and intraobserver reproducibility of cytological examinations of the thyroid has been very little investigated. We studied 74 patients who underwent FNAC and a thyroidectomy. Th...

Virilizing ovarian tumors are a rare cause of hyperandrogenism; they account for 1–2% of all ovarian tumors being the Leydig cell tumor the most common one.We report the case of a 76-year old woman with type 2 diabetes that was referred for androgenic alopecia with 3 years evolution and a recent facial, peri-areolar and dorsal hirsutism. A diagnosis of hypertension was made 18 months previously, and she was on a four anti-hypertensive drug regimen. ...

Introduction: Gynecomastia is a relatively common reason for consultation, with a high prevalence in the neonatal period, puberty and with aging. The diagnostic approach should be more thorough in normal-weight individuals with recent onset of gynecomastia, rapid growth of breast tissue, or in the setting of a large painful breast. Besides the evaluation of liver function, testosterone, estradiol, LH and β-hCG, testicular ultrasound evaluation is important to exclude test...

Introduction: Type 1 autoimmune polyglandular syndrome is a rare entity, presenting typically during childhood and comprising a variable combination of autoimmune endocrine and non-endocrine diseases that differ in their immunological features. This phenotypical heterogeneity may difficult the identification of this syndrome.Clinical case: 33 year-old female, presenting with secondary amenorrhoea at the age of 13, and by that date diagnosed with hypergon...

Introduction: Pituitary apoplexy is a rare disease which results of haemorrhage and/or infarction of pituitary gland. The optimal management of this problem still remains controversial between surgery and conservative treatment.Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow up of patients with apoplexy. Methods:Retrospective study of 35 pituitary apoplexy followed in a portuguese hospital from 2006 to 2016.<p...

Introduction: Leydig cell tumors are a type of steroid cell tumor, account for 0.1% of all ovarian tumors. The clinical presentation is usually a hyperandrogenic state with signs of virilisation. The tumor has a benign behavior, with an excellent prognosis and reversion of symptoms after surgical treatment.Case report: Woman, 81 years-old, nulliparus, with clinic hyperandrogenism and vaginal bleeding during the last year. She had history of dementia synd...