Endocrine Abstracts

Background: Diabetic autonomic neuropathy (DAN) is among the least recognized and understood complication of diabetes despite its significant negative impact on survival and quality of life in people with diabetes. Diabetic neuropathies including cardiac autonomic neuropathy (CAN), are a common chronic complication of type 1 and Type 2 diabetes and confer a high morbidity and mortality to diabetic pateints. The reported prevalence of CAN varies greatly depending on the criteri...

Introduction: Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves’ disease, with most patients being in hyperthyroid state. PM has also rarely been described in Hashimoto thyroiditis.Case report: A 61-year old Caucasian woman attended our outpatient dermatology clinic for evaluation and management of bilateral erythema, involving the lower two-thirds of the pretibial regions. She reported appearance of the same lesion 11 years a...

Aplastic anemia is an idiopathic/idiosyncratic or hereditary bone marrow failure characterized by hypocellular bone marrow and pancytopenia without abnormal infiltration and increase in reticulin fibers. Papillary thyroid cancer (PTC) constitutes 85% of all differentiated thyroid cancers. There is no data on the application of radioactive iodine treatment for the treatment of high-risk differentiated thyroid carcinoma detected in the subjects with aplastic anemia.<p class=...

Purpose: The study evaluated the effects of laser ablation of adrenal glands and results of regeneration using low-vacuum scanning electron microscopy for modeling the effects of laser ablation on pathological focus in the adrenal glands.Methods/design: A study performed on the rats (n=19, male, Wistar line) with weighing 335.3±24.9 g. At 14 of them (control 5 intact rat) under general anaesthetic was performed local laser ablation part of ...

Background and Aim: Supplementation with precursors of nicotinamide adenine dinucleotide (NAD), was shown to be beneficial in preventing metabolic dysfunction in mice, which is induced by feeding a high fat diet. We compared the effect of nicotinamide riboside (NR) supplementationon whole-body energy metabolism and mitochondrial function in two widely used diet-induced obesity mouse models.Methods: Mice were fed a high fat diet (HFD, 60% fat) or standard...

Introduction: Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs.Methods/des...

Environmental pollution by microplastics has been transcending usual stakeholders (such as policymakers and scientists) to become a public concern. The conspicuous, widespread occurrence of (micro)plastics together with the publicization by the media of its potential impacts on wildlife and human health have contributed for this state of affairs. Microplastics, typically defined as plastic particles smaller than 5 mm, have been detected throughout the marine, freshwater and te...

The classic clinic manifestation of primary hyperparathyroidism (PHPT) is osteitis fibrosa cystica, a severe skeletal disease characterized by brown tumors, bone cysts and deformities, due to extremely elevated bone resorption elicited by continuously high parathyroid hormone (PTH) levels. In cardiovascular system there may be shortened QT interval, deposition of calcium in heart valves, coronary arteries, and myocardial fibers. Here, we report a case with PHPT, who have anore...

Introduction: Islets of Langerhans are well innervated and vascularized, however, the regulatory mechanisms for innervation and vascularization are not well clarified. In mice deficient for proglucagon-derived peptides (Gcg–gfp/gfp: GCGKO), islet cells that express green fluorescent protein (GFP) under the control of glucagon promoter (‘α”-cells) display hyperplasia and number of islets is increased. The present study was aimed to clarify role of the proglu...

In addition to their essential role in fetal lung development, glucocorticoids promote late-gestation maturation of the fetal heart as shown by severe functional impairment, structural disorganisation and transcriptome immaturity in fetal hearts of glucocorticoid receptor-deficient (GR-/-) mice. Here we use primary fetal mouse cardiomyocytes (E16-E17.5) to investigate whether these effects of glucocorticoids result from direct actions of GR and whether they are independent of ...